Results 121 to 130 of about 4,715 (225)

The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis

Biology of the Cell, Volume 118, Issue 10, October 2026.
We highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Sandrine Fraboulet, Omar Aldarawish, Monika Elzbieta Dolega   +2 more
wiley   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Metallopeptidase [PDF]

, 2020
openaire   +1 more source

Pseudomonas syringae pv. tabaci 8018 is Virulent Against Tobacco Cultivars N509 and Burley21 Due to Spontaneous Mutation in hopAZ1

Molecular Plant Pathology, Volume 27, Issue 10, October 2026.
Pta8018 lacks the virulence genomic island GI‐1, lost tabtoxin biosynthesis and exhibits reduced virulence against the tobacco cultivar Xanthi NC. Pta8018 has a mutated hopAZ1, allowing it to infect N509 and Burley21. ABSTRACT The complete genome sequence of a relatively weak virulent tobacco pathogen, Pseudomonas syringae pv. tabaci 8018 (Pta8018) was
Yuto Hiraki, Kana Kuroe, Hidenori Matsui, Motoki Shimizu, Nanami Sakata, Yoshiteru Noutoshi, Kazuhiro Toyoda, Yuki Ichinose   +7 more
wiley   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini, Ludovica Donadini, Pritha Dey, Federica Franciosi, Valentina Lodde, Maria Belen Rabaglino, Alberto Maria Luciano   +6 more
wiley   +1 more source

Potentiation of des-Arg 9 -Kallidin-Induced Vasoconstrictor Responses by Metallopeptidase Inhibition in Isolated Human Umbilical Artery

, 2020
Several metallopeptidases have been reported to be involved in bradykinin (BK) B 1 receptor agonist metabolism. Our goal was to evaluate in vitro roles of metallopeptidases [e.g., neutral endopeptidase (NEP), aminopeptidase M (APM), and angiotensin ...
Rodolfo Pedro Zold, Rothlin, Facundo Germá, Camila Lidia Brodsky, Paula Tamara Pelorosso   +4 more
core  

Crystal structure of PM1Pgh, a poly-γ-glutamate hydrolase from Bacillus phage PM1. [PDF]

Acta Crystallogr F Struct Biol Commun
Abe K, Fukui K, Ogura Y.
europepmc   +1 more source

Comparative genomic and functional insights into life-cycle plasticity and host adaptation in a wild Nippostrongylus brasiliensis strain from Guangzhou. [PDF]

BMC Genomics
Pan X, Lu J, Wang C, Song Y, Li H, Wan M, Xiao L, Feng Y, Yuan D.   +8 more
europepmc   +1 more source

Rethinking Suicide Thi4 Thiazole Synthases: Comparative Genomic Insights and Pilot Functional Evidence. [PDF]

ACS Omega
Oliveira-Filho ER, Van Gelder K, Obe D, Voiniciuc C, Wilson MA, Hanson AD.   +5 more
europepmc   +1 more source