Results 101 to 110 of about 4,715 (225)

A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral-membrane metallopeptidases [PDF]

, 2013
et al.In the search for structural models of integral-membrane metallopeptidases (MPs), we discovered three related proteins from thermophilic prokaryotes, which we grouped into a novel family called minigluzincins.
Canals, Albert, Arolas, Joan L., López-Pelegrín, Mar, Gomis-Rüth, F. Xavier, Cerdà-Costa, Núria   +4 more
core   +1 more source

Divergent Healing Trajectories Among Common Mechanical Skin Wound Types in Post‐Smolt Atlantic Salmon (Salmo salar Linnaeus, 1758)

Journal of Fish Diseases, EarlyView.
ABSTRACT Mechanical wounds are a common form of skin damage in Atlantic salmon (Salmo salar Linnaeus, 1758) aquaculture and can predispose fish to secondary infections. Such wounds often arise from routine farming practices, including delousing operations.
Kasidis Chaiyasut, Rose Ruiz Daniels, Christian Karlsen, Barry Bradford, Gunhild Seljehaug Johansson, Miroslava Hansen, Marta Bou, Marianne Vaadal, Lene Rydal Sveen   +8 more
wiley   +1 more source

Proteolytic activity in Encephalitozoon cuniculi sporogonial stages : Predominance of metallopeptidases including an aminopeptidase-P-like enzyme

, 2005
International audienceA fraction enriched in spore precursor cells (sporoblasts) of the microsporidian Encephalitozoon cuniculi, an intracellular parasite of mammals, was obtained by Percoll gradient centrifugation.
Méténier, Guy, Chavant, Patrick, Prensier, Gérard, Chambon, Christophe, C., Wawrzyniak, Ivan, Taupin, Vanessa, El Alaoui, Hicham, Vivarès, Christian   +7 more
core   +1 more source

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Journal of Periodontal Research, EarlyView.
This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola   +4 more
wiley   +1 more source

Long‐term stability of horizontal bone augmentation at implant sites

Periodontology 2000, EarlyView.
Abstract Horizontal bone augmentation is a fundamental surgical procedure in regenerative implant dentistry. In recent decades, this procedure has evolved, enabling clinicians to achieve predictable and stable horizontal bone augmentation that supports dental implant restorations.
Jia‐Hui Fu, Hui Jia Sophia Choo, Ding‐Sen Ong, Henry Kwek   +3 more
wiley   +1 more source

Enhancing colonic anastomotic healing with a novel melatonin‐loaded PLGA matrix

Experimental Physiology, EarlyView.
Abstract Anastomotic leakage continues to be a severe and prevalent complication in colorectal surgery, leading to elevated morbidity and mortality rates despite modern advancements in surgical and perioperative care. To address this persistent clinical challenge, the aim of the present study was to engineer a biocompatible poly(lactic‐co‐glycolic acid)
Ufuk Demir, Zekiye Gülfem Yurtgezen, Gülfem Erbil, Oruç Numan Gökçe, Ayhan Oral, Metehan Uzun   +5 more
wiley   +1 more source

Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases

, 2010
Pseudomonas aeruginosa is an opportunist Gram-negative bacterial pathogen responsible for a wide range of infections in immunocompromized individuals and is a leading cause of mortality in cystic fibrosis patients. A number of secreted virulence factors,
Steven J. Gamblin, Gamblin, SJ, Loretta M. Murphy, Rebecca Conners, Spencer, J, Conners, R, Sessions, RB, James Spencer, Richard B. Sessions, Murphy, LM   +9 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Investigating and Annotating the Human Peptidome Profile from Urine under Normal Physiological Conditions

Proteomes
Examining the composition of the typical urinary peptidome and identifying the enzymes responsible for its formation holds significant importance, as it mirrors the normal physiological state of the human body.
Amr Elguoshy, Keiko Yamamoto, Yoshitoshi Hirao, Tomohiro Uchimoto, Kengo Yanagita, Tadashi Yamamoto   +5 more
doaj   +1 more source

Identifying Co‐Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Nutrigenomics investigates how nutrients modulate gene expression. Among them, fatty acids (FA) play important roles in regulating gene transcription, while long non‐coding RNAs (lncRNAs) may be associated with gene regulation and metabolic diseases.
Lucas Echevarria Nascimento, Bruna Pereira Martins da Silva, Camila Sabino de Oliveira, Mariah Castro Durval, Felipe André Oliveira Freitas, Fernanda Nery Ciconello, Izally Carvalho Gervásio, Simara Larissa Fanalli, Pablo Augusto de Souza Fonseca, Beatriz Gutiérrez‐Gil, Vivian Vezzoni de Almeida, Aline Silva Mello Cesar   +11 more
wiley   +1 more source