Hierarchically-structured metalloprotein composite coatings biofabricated from co-existing condensed liquid phases [PDF]
Nature Communications, 2020 The mussel byssus cuticle is a wear-resistant and extensible metalloprotein composite. Here, the authors probed the cuticle nanostructure and composition before, during and after fabrication revealing a crucial role of metal-binding proteins that self ...
Franziska Jehle +5 more
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Recent advances and future challenges in predictive modeling of metalloproteins by artificial intelligence [PDF]
Molecules and Cells: Metal coordination is essential for structural/catalytic functions of metalloproteins that mediate a wide range of biological processes in living organisms. Advances in bioinformatics have significantly enhanced our understanding of metal-binding sites
Soohyeong Kim +4 more
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Improving Data Representation of Metalloproteins in the Protein Data Bank [PDF]
Structural DynamicsThe Protein Data Bank (PDB) was established in 1971 as the first open-access digital data resource in biology, initially comprising just seven X- ray crystal structures of proteins.
Alison Biester +6 more
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Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state [PDF]
Quantitative Plant BiologyThe micronutrient zinc (Zn) is often poorly available but toxic when present in excess, so a tightly controlled Zn homoeostasis network operates in all organisms. This review summarizes our present understanding of plant Zn homoeostasis.
Ute Krämer
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Methanogenesis marker 16 metalloprotein is the primary coenzyme M synthase in Methanosarcina acetivorans. [PDF]
PLoS Genetics2-mercaptoethanesulfonate (Coenzyme M, CoM) is an organic sulfur-containing cofactor used for hydrocarbon metabolism in archaea and bacteria. In archaea, CoM serves as an alkyl group carrier for enzymes belonging to the alkyl-CoM reductase family ...
Grayson L Chadwick +3 more
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Investigation of the Ferredoxin’s Influence on the Anaerobic and Aerobic, Enzymatic H2 Production
Frontiers in Bioengineering and Biotechnology, 2021 Ferredoxins are metalloproteins that deliver electrons to several redox partners, including [FeFe] hydrogenases that are potentially a component of biological H2 production technologies.
Jamin Koo, Yeeun Cha
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Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry
mBio, 2022 Copper (Cu) is an essential micronutrient for cells, but in excess it is cytotoxic. How Cu is cytotoxic is the subject of recent work by L. Zuily, N.
Charlotte I. Z. O’Hern +1 more
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Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli
Nature Communications, 2022 New cryo-EM structures of the formate hydrogenlyase complex from the model bacterium E. coli clarify how electrons and protons move through the complex and are combined to make H2 gas.
Ralf Steinhilper +3 more
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Towards the spatial resolution of metalloprotein charge states by detailed modeling of XFEL crystallographic diffraction. [PDF]
, 2020 Oxidation states of individual metal atoms within a metalloprotein can be assigned by examining X-ray absorption edges, which shift to higher energy for progressively more positive valence numbers.
Holton, James M +3 more
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Molecules, 2021 Globally, human exposure to environmental pollutants causes an estimated 9 million deaths per year and it could also be implicated in the etiology of diseases that do not appear to have a genetic origin.
Tristen G. Bridle +2 more
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