Results 31 to 40 of about 22,661 (298)

Matrix Metalloproteinase-9 and Inflammation in Different Types of Multiple Sclerosis [PDF]

, 2016
Different clinical courses of multiple sclerosis, heterogeneity of its clinical implications, different effect of immunomodulatory therapy for the same clinical forms implies various pathogenetic mechanisms of central nervous system damage at this ...
Chernenko, M. (Maksym), Nehreba, T. (Tatyana), Vasylovskyy, V. (Vitaliy), Voloshyna, N. (Nataliya), Vovk, V. (Viktoriya)   +4 more
core   +2 more sources

The pH-Induced Selectivity Between Cysteine or Histidine Coordinated Heme in an Artificial α-Helical Metalloprotein.

Angewandte Chemie, 2020
De Novo metalloprotein design assesses the relationship between metal active site architecture and catalytic reactivity. Herein, we use an α-helical scaffold to control the iron coordination geometry when a heme cofactor is allowed to bind to either ...
K. Koebke, Toni Kühl, E. Lojou, B. Demeler, B. Schoepp‐Cothenet, O. Iranzo, V. Pecoraro, A. Ivancich   +7 more
semanticscholar   +1 more source

How Theoretical Evaluations Can Generate Guidelines for Designing/Engineering Metalloproteins with Desired Metal Affinity and Selectivity

Molecules, 2022
Almost half of all known proteins contain metal co-factors. Crucial for the flawless performance of a metalloprotein is the selection with high fidelity of the cognate metal cation from the surrounding biological fluids.
Todor Dudev
doaj   +1 more source

Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors. [PDF]

, 2011
Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study.
de Oliveira, César AF, Durrant, Jacob D, McCammon, J Andrew   +2 more
core   +1 more source

Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels

Redox Biology, 2022
Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation and pericellular oxygen ...
Gulsah Sevimli, Matthew J. Smith, Tuba Akgul Caglar, Şükriye Bilir, Melike Secilmis, Hamza Y. Altun, Esra N. Yigit, Fan Yang, Thomas P. Keeley, Roland Malli, Gürkan Öztürk, Giovanni E. Mann, Emrah Eroglu   +12 more
doaj   +1 more source

Probing a Complex of Cytochromecand Cardiolipin by Magnetic Circular Dichroism Spectroscopy: Implications for the Initial Events in Apoptosis [PDF]

, 2011
Oxidation of cardiolipin (CL) by its complex with cytochrome c (cyt c) plays a crucial role in triggering apoptosis. Through a combination of magnetic circular dichroism spectroscopy and potentiometric titrations, we show that both the ferric and ferrous
Armstrong F. A., Barker P. D., Basova L. V., Battistuzzi G., Battistuzzi G., Belikova N. A., Belikova N. A., Bradley J. M., Bushnell G. W., Cheesman M. R., Cheesman M. R., Ferrer J. C., Foote N., Gadsby P. M. A., Gadsby P. M. A., Gary Silkstone, Hendriks J. H. M., Jing W. G., Julea N. Butt, Justin M. Bradley, Kagan V. E., Kagan V. E., Kalanxhi E., Kapetanaki S. M., Kapralov A. A., Marritt S. J., Michael T. Wilson, Millis K. K., Myles R. Cheesman, Nantes I. L., Oganesyan V. S., Petrovic J., Pettigrew G. W., Pond A. E., Rawlings J., Rigby S. E. J., Rytomaa M., Salamon Z., Sinibaldi F., Sutherland J., Tezcan F. A., Wackerbarth H., Zucchi M. R.   +42 more
core   +1 more source

Oxygen-Sensitive Metalloprotein Structure Determination by Cryo-Electron Microscopy

Biomolecules, 2022
Metalloproteins are involved in key cell processes such as photosynthesis, respiration, and oxygen transport. However, the presence of transition metals (notably iron as a component of [Fe-S] clusters) often makes these proteins sensitive to oxygen ...
Mickaël V. Cherrier, Xavier Vernède, Daphna Fenel, Lydie Martin, Benoit Arragain, Emmanuelle Neumann, Juan C. Fontecilla-Camps, Guy Schoehn, Yvain Nicolet   +8 more
doaj   +1 more source

Electrochemical titrations and reaction time courses monitored in situ by magnetic circular dichroism spectroscopy [PDF]

, 2011
Magnetic circular dichroism (MCD) spectra, at ultraviolet–visible or near-infrared wavelengths (185–2000 nm), contain the same transitions observed in conventional absorbance spectroscopy, but their bisignate nature and more stringent selection rules ...
Abramson, Allen, Armstrong, Cheesman, Cheesman, Cheesman, Cheesman, Craft, Dooley, Duin, Farrar, Field, Fulop, Gadsby, Gamelin, Gates, George, Hadler, Horio, Hänzelmann, Johnson, Johnson, Johnson, Jones, Julea N. Butt, Justin M. Bradley, Kemp, Kobayashi, Koppenhofer, Larrabee, Male, Marritt, Marritt, Mitić, Mitou, Moir, Myles R. Cheesman, Paes de Sousa, Pauleta, Quintanar, Rasmussen, Richter, Rupnik, Simon, Solomon, Solomon, Solomon, Suharti, Thomson, Thomson, van Gelder, Vickery, Walters   +52 more
core   +1 more source

Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]

, 2009
Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Baur, Dorothee M., Besig, Sophie, Braun, Thomas, Hoefler, Heinz, Langer, Rupert, Perren, Aurel, Prinz, Christian, Rad, Roland, Voland, Petra   +8 more
core   +2 more sources

The Fe Protein: An Unsung Hero of Nitrogenase

Inorganics, 2018
Although the nitrogen-fixing enzyme nitrogenase critically requires both a reductase component (Fe protein) and a catalytic component, considerably more work has focused on the latter species.
Andrew J. Jasniewski, Nathaniel S. Sickerman, Yilin Hu, Markus W. Ribbe   +3 more
doaj   +1 more source