Metalloprotein‐based MRI probes [PDF]
FEBS Letters, 2013 Metalloproteins have long been recognized as key determinants of endogenous contrast in magnetic resonance imaging (MRI) of biological subjects. More recently, both natural and engineered metalloproteins have been harnessed as biotechnological tools to probe gene expression, enzyme activity, and analyte concentrations by MRI.
Matsumoto, Yuri, Jasanoff, Alan Pradip
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Electron Flow through Metalloproteins [PDF]
Chemical Reviews, 2010 Electron transfers in photosynthesis and respiration commonly occur between metal-containing cofactors that are separated by large molecular distances. Understanding the underlying physics and chemistry of these biological electron transfer processes is the goal of much of the work in our laboratories.
Gray, Harry B., Winkler, Jay R.
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Finding High-Quality Metal Ion-Centric Regions Across the Worldwide Protein Data Bank
Molecules, 2019 As the number of macromolecular structures in the worldwide Protein Data Bank (wwPDB) continues to grow rapidly, more attention is being paid to the quality of its data, especially for use in aggregated structural and dynamics analyses. In this study, we
Sen Yao, Hunter N.B. Moseley
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Frontiers in Microbiology, 2016 The regulator of citrate metabolism, CitO, from Enterococcus faecalis belongs to the FCD family within the GntR superfamily. In the presence of citrate, CitO binds to cis-acting sequences located upstream of the cit promoters inducing the expression of ...
Victor S. Blancato +5 more
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RPL6: A Key Molecule Regulating Zinc- and Magnesium-Bound Metalloproteins of Parkinson’s Disease
Frontiers in Neuroscience, 2021 Parkinson’s disease (PD) is a progressive neurodegenerative disease with no definite molecular markers for diagnosis. Metal exposure may alter cellular proteins that contribute to PD.
Athira Anirudhan +7 more
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Zinc Gluconate in the Treatment of Dysgeusia—a Randomized Clinical Trial [PDF]
, 2005 In the treatment of dysgeusia, the use of zinc has been frequently tried, with equivocal results. The aim of the present randomized clinical trial, which involved a sufficiently large sample, was therefore to determine the efficacy of zinc treatment ...
Friess, Wolfgang +6 more
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Machine learning differentiates enzymatic and non-enzymatic metals in proteins
Nature Communications, 2021 The authors generate the largest structural dataset of enzymatic and non-enzymatic metalloprotein sites to date. They use this dataset to train a decision-tree ensemble machine learning algorithm that allows them to distinguish between catalytic and non ...
Ryan Feehan +2 more
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Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients. [PDF]
PLoS ONE, 2015 Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the ...
Michael Syka +7 more
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Serum levels of matrix metalloproteinases-2 and-9 and their tissue inhibitors in inflammatory neuromuscular disorders [PDF]
, 2006 We monitored serum levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) before and during intravenously applied immunoglobulin (IVIG) therapy in 33 patients with chronic immune-mediated neuropathies and myopathies and 15 ...
B.G.H. Schoser +15 more
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Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]
, 2017 The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada +9 more
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