Results 41 to 50 of about 22,892 (210)

Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins

IUCrJ, 2019
An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein microcrystals using identical fixed-target supports at both synchrotrons and X-ray free-electron lasers
Ali Ebrahim, Tadeo Moreno-Chicano, Martin V. Appleby, Amanda K. Chaplin, John H. Beale, Darren A. Sherrell, Helen M. E. Duyvesteyn, Shigeki Owada, Kensuke Tono, Hiroshi Sugimoto, Richard W. Strange, Jonathan A. R. Worrall, Danny Axford, Robin L. Owen, Michael A. Hough   +14 more
doaj   +1 more source

Zinc: Multidimensional Effects on Living Organisms

Biomedicines, 2021
Zinc is a redox-inert trace element that is second only to iron in abundance in biological systems. In cells, zinc is typically buffered and bound to metalloproteins, but it may also exist in a labile or chelatable (free ion) form.
Math P. Cuajungco, Maria Soledad Ramirez, Marcelo E. Tolmasky   +2 more
doaj   +1 more source

Kinetics of the reduction of metalloproteins by chromous ion [PDF]

, 1972
The reduction of Cu(330) in Rhus vernicifera laccase by chromous ion is 30% faster than reduction of Cu(614) at room temperature [pH 4.8, µ = 0.1 (NaCl)], and two parallel first-order paths, attributed to heterogeneity of the protein, are observed at ...
Dawson, J. W., Gray, H. B., Holwerda, R. A., Westhead, E. W.   +3 more
core  

Mercury and selenium binding biomolecules in terrestrial mammals (Cervus elaphus and Sus scrofa) from a mercury exposed area [PDF]

, 2017
Acknowledgements The authors are grateful to Junta de Comunidades de Castilla-La Mancha (PCC-05-004-2, PAI06-0094, PCI-08-0096, PEII09-0032-5329) and the Ministerio de Economía y Competitividad (CTQ2013-48411-P) for financial support. M.J.
Fariñas, N. Rodríguez, Krupp, E., Martín-Doimeadiosa, R. C. Rodríguez, Matteo, R., Nevado, J. J. Berzas, Ropero, M. J. Patiño   +5 more
core   +1 more source

Cu(I) Is a Game Changer in the Arrest of Cu(Aβ)‐Induced ROS Production in the Presence of Competing Zn(II) Ions

Chemistry – A European Journal, EarlyView.
ABSTRACT ROS production due to Cu(amyloid‐β) redox cycling is proposed to contribute to the oxidative stress observed in Alzheimer's disease brains. We previously reported on a nitrogen and sulfur‐containing ligand, L, able to arrest Cu(Aβ)‐induced ROS production [Chem. Eur. J. 2023, 29,].
Marielle Drommi, Kyangwi Patrick Malikidogo, Elena Atrián‐Blasco, Charlène Esmieu, Christelle Hureau   +4 more
wiley   +1 more source

Absolute Configuration Determination with Electronically Enhanced Vibrational Circular Dichroism

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
We introduce a practical workflow for simulating vibrational circular dichroism spectra enhanced by vibronic coupling. We achieve qualitative agreement with experiment for Co(II) and Ni(II) spartein complexes, circumventing inaccuracies in theoretical excitation energy predictions.
Mariia Sapova, Chandan Kumar, Sahar Ashtari‐Jafari, Wybren J. Buma, Lucas Visscher   +4 more
wiley   +2 more sources

Metallomics in environmental and health related research: Current status and perspectives [PDF]

, 2013
Metals and metalloids play distinct roles in human health, either beneficial or toxic, depending on their concentrations and species. There is an increasing interest in metals uptake, trafficking, function, and exertion in microorganisms to maintain and ...
G.B., J, He, B, Hu, L, Sun, H, Wang, Y
core   +1 more source

Metal‐Directed Self‐Assembly in a Beta‐Sheet Miniprotein Scaffold

European Journal of Inorganic Chemistry, EarlyView.
A rationally engineered miniprotein, V14C, which is based on the beta β‐sheet Foldon domain, self‐assembles via a metal‐binding site to form well‐defined oligomers in the presence of Zn2+, Hg2+, and Cd2+. This modular design expands the toolbox for creating custom metalloproteins, enabling studies of metal–protein interactions for biochemical functions
Chandan Muni Reddy, Marcos R. Conde González, Jürgen H. Gross, Franziska Thomas   +3 more
wiley   +1 more source

Probing Metal Ion Discrimination in a Protein Designed to Bind Uranyl Cation With Femtomolar Affinity

Frontiers in Molecular Biosciences, 2019
The design of metal-binding sites in proteins that combine high affinity with high selectivity for the desired metal ion remains a challenging goal.
Marie Hoarau, Karl J. Koebke, Zhan Chen, E. Neil G. Marsh, E. Neil G. Marsh   +4 more
doaj   +1 more source

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry [PDF]

, 2013
Metals often determine the chemical reactivity of the proteins to which they are bound. Each cell in the body tightly maintains a unique metalloproteomic profile, mostly dependent on function.
Bush, AI, Cherny, RA, Doble, PA, Grimm, R, Grubman, A, Hare, DJ, Liddell, JR, Lothian, A, Masters, CL, Matsuda, T, Roberts, BR, Ryan, TM, White, AR   +12 more
core   +2 more sources