Metamizole (dipyrone) – cytotoxic and antiproliferative effects on HeLa, HT-29 and MCF-7 cancer cell lines [PDF]
Biotechnology & Biotechnological Equipment, 2018 Cancer pain treatment is a big challenge for healthcare providers and patients as well. The wide range of non-steroidal anti-inflammatory drugs (NSAIDs) used as painkillers in cancer patients, requires in-depth characterization of their effect on the ...
Irina Nikolova +6 more
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Ventral posteromedial nucleus of the thalamus as a neuroanatomical target for the anticephalalgic action of valproic acid and metamizole [PDF]
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022 Introduction. Valproic acid and metamizole are widely used in the treatment of primary headaches. However, despite the drugs’ proven clinical efficacy, the neurophysiological mechanisms underlying their therapeutic action are poorly understood.
A. Yu. Sokolov, O. A. Lyubashina
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A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use [PDF]
Scientific ReportsMetamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi +7 more
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Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis [PDF]
Biomedicines, 2020 Metamizole is an analgesic, whose pharmacological and toxicological properties are attributed to N-methyl-aminoantipyrine (MAA), its major metabolite.
Deborah Rudin +4 more
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Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis [PDF]
Animals, 2020 Pain management during in vivo experiments is an animal welfare concern and is in many countries also legally required. In this study, we evaluated C57Bl/6J mice when 3 g/L metamizole or 1 g/L tramadol was provided via drinking water, before and during ...
Guanglin Tang +4 more
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PLoS ONE, 2020 BACKGROUND:Normothermic ex vivo liver perfusion (NEVLP) is a promising strategy to increase the donor pool in liver transplantation. Small animal models are essential to further investigate questions regarding organ preservation and reconditioning by ...
Felix Claussen +12 more
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Metamizole does not affect fracture healing in a murine ischemia model [PDF]
Frontiers in PhysiologyMetamizole is a commonly used analgesic drug in clinical fracture management, which does not affect the healing process under physiological conditions.
Christian Schönbeck +13 more
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Risk Factors for Intolerable Postoperative Pain After Vitreoretinal Surgery Under AoA-Guided General Anesthesia with Intravenous COX-3 Inhibitors: A Post Hoc Analysis [PDF]
PharmaceuticalsBackground/Objectives: Intolerable postoperative pain perception (IPPP) may occur in patients undergoing vitreoretinal surgery (VRS), while general anesthesia (GA) is often preferred over regional techniques due to multiple contraindications ...
Michał J. Stasiowski +3 more
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Noramidopyrine (Metamizol) and acute interstitial nephritis [PDF]
Nephrology Dialysis Transplantation, 1998 amount ingested: 30 g). On admission his serum creatiIntroduction nine and blood urea nitrogen (BUN) were 4.5 mg/dl and 39 mg/dl respectively. Urinalysis revealed 30 mg/dl Noramidopyrine (Metamizol ) is a non-narcotic, protein, 3+ positive for blood (dipstick), and 5–10 analgesic and antipiretic pyrazolone derivative which red blood cells and 3–5 white
V. Berruti +6 more
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The Uncertainties of Metamizole Use [PDF]
Clinical Pharmacology & Therapeutics, 2021 Ingolf Cascorbi
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