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A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use [PDF]

Scientific Reports
Metamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi, Mario Gaio, Donatella Ruggiero, Consiglia Riccardi, Cecilia Cagnotta, Ciro Pentella, Annalisa Capuano, Concetta Rafaniello   +7 more
doaj   +3 more sources

Metamizole does not affect fracture healing in a murine ischemia model [PDF]

Frontiers in Physiology
Metamizole is a commonly used analgesic drug in clinical fracture management, which does not affect the healing process under physiological conditions.
Christian Schönbeck, Janine Stutz, Sebastian T. Schreiber, Lukas Keller, Chiara Siep, Wolfgang Metzger, Mario Giorgi, Irene Sartini, Tobias Fritz, Tim Pohlemann, Michael D. Menger, Emmanouil Liodakis, Matthias W. Laschke, Marcel Orth   +13 more
doaj   +3 more sources

Does Metamizole Cause Less Acute Kidney Injury than Non-Steroidal Anti-Inflammatory Drugs When Combined with Diuretics and Antihypertensives? [PDF]

Toxics
The concurrent use of (a) diuretics, (b) renin–angiotensin–aldosterone system inhibitors (RAASIs), and (c) non-steroidal anti-inflammatory drugs (NSAIDs) or metamizole, known as the triple whammy (TW) combination, increases the risk of acute kidney ...
Dulce Maria Calvo, Luis Carlos Saiz, Leire Leache, Maria C. Celaya, Marta Gutiérrez-Valencia, Alvaro Alonso, Juan Erviti   +6 more
doaj   +3 more sources

Metamizole-Induced Agranulocytosis. [PDF]

Dtsch Arztebl Int
Kohn D, Wetzig T.
europepmc   +4 more sources

Metamizole-Induced Agranulocytosis: A Case Report. [PDF]

Cureus
Metamizole, a widely used analgesic and antipyretic, has been associated with rare but potentially life-threatening hematological adverse reactions, such as agranulocytosis. This case report highlights the diagnostic complexity and clinical management of
Cartucho J, Ruivo A, Bonito I, Fernandes C, Ginga MDR.   +4 more
europepmc   +2 more sources

Learning From the Uncommon in Common Practice: A Case Report on Metamizole-Induced Agranulocytosis. [PDF]

Cureus
Agranulocytosis is a severe haematological disorder with multiple aetiologies, among which drug-induced causes are clinically significant. Metamizole is a non-opioid analgesic and antipyretic agent, used for the management of severe pain and high fever ...
Cunha M, Fonseca-Dias F, Marinho R, Sampaio M, Marinho A.   +4 more
europepmc   +2 more sources

Pharmacogenetics of metamizole-induced agranulocytosis: a systematic review and drug regulation implications. [PDF]

Front Pharmacol
Introduction Metamizole (dipyrone) is a widely used analgesic and antipyretic, but its use has been restricted in some countries due to the risk of metamizole-induced agranulocytosis (MIA).
Fidelis GFS, Dagli-Hernandez C, Martinelli RP, Marzuki JE, Baharuddin B, Yue QY, Edwards B, Pincinato EC, Moriel P.   +8 more
europepmc   +2 more sources

Pharmacology and relevant drug interactions of metamizole. [PDF]

Br J Clin Pharmacol
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice.
Brinkman DJ, Hendriksen LC, Rigter IM, Hollmann MW.   +3 more
europepmc   +2 more sources

Adverse Events Following Vitreoretinal Surgeries Under Adequacy of Anesthesia with Combined Paracetamol/Metamizole-Additional Report. [PDF]

J Clin Med
Background/Objectives: Some patients undergoing vitreoretinal surgery (VRS) require general anesthesia (GA), despite the possibility of developing intolerable postoperative pain perception (IPPP).
Marczak K, Stasiowski MJ, Lyssek-Boroń A, Zmarzły N.   +3 more
europepmc   +2 more sources

Drug-Induced Liver Injury Caused by Metamizole: Identification of a Characteristic Injury Pattern. [PDF]

Liver Int
Drug‐induced liver injury (DILI) due to metamizole has gained increasing attention. Causality assessment remains a challenge, especially in patients with co‐medications. We therefore aimed to further characterise metamizole DILI cases.
Weber S, Erhardt F, Allgeier J, Saka D, Donga N, Neumann J, Lange CM, Gerbes AL.   +7 more
europepmc   +2 more sources