Results 11 to 20 of about 9,301 (237)

Metamizole limits proliferation in chronic myeloid leukemia cells and triggers apoptosis via the bax/bcl-2/caspase-3 cascade. [PDF]

Med Oncol
Metamizole is a controversial non-steroidal anti-inflammatory drug because it may cause agranulocytosis usually in long-term use. It may reduce proliferation while increasing apoptosis in some cancer cells.
Maytalman E, Nemutlu Samur D.
europepmc   +2 more sources

The effect of scheduled metamizole on opioid consumption after cardiac surgery [PDF]

Frontiers in Pharmacology
This retrospective study evaluates the impact of implementing a standardized scheduled metamizole dosing protocol within a multimodal analgesia approach after cardiac surgery.
Chen Seidenberg, Adina Grunberger, Ruth Mishali, Avi Hefets, Pierre Singer, Pierre Singer, Eric Setton, Michal Slevin Kish   +7 more
doaj   +2 more sources

Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database

Swiss Medical Weekly
OBJECTIVE: To investigate claims patterns for metamizole and other non-opioid analgesics in Switzerland. To characterise users of these non-opioid analgesics regarding sex, age, comedications and canton of residence.
Stephan Gut, Marlene Rauch, Manuel Haschke, Carola A. Huber, Jan Gaertner, Nadine Schur, Christoph R. Meier, Julia Spoendlin   +7 more
doaj   +2 more sources

Case Report: Agranulocytosis in a Child Following Metamizole Use - A Diagnostic Challenge. [PDF]

Acta Med Acad
Objective. This case report describes a young female who developed agranulocytosis with blast cells in peripheral blood following prolonged metamizole use after ankle surgery. Case Report.
Pirnat A, Prelog T, Jazbec J, Trampuš Bakija A.   +3 more
europepmc   +2 more sources

Metamizole induces voriconazole metabolism and results in subtherapeutic voriconazole concentrations. [PDF]

Br J Clin Pharmacol
Voriconazole is extensively metabolized via cytochrome P450 (CYP) enzymes, predominantly CYP2C19 and CYP3A4. Drugs influencing the activity or expression of CYP enzymes can cause clinically relevant changes in the metabolism and voriconazole exposure ...
Baan SD, Touw DJ, Lub-de Hooge MN, Oude Munnink TH.   +3 more
europepmc   +2 more sources

Across the Border: A Metamizole Drug-Induced Liver Injury. [PDF]

Cureus
Metamizole (dipyrone) is a medication with analgesic, antipyretic, and spasmolytic properties, widely used in Mexico and other Latin American countries. It is often grouped with non-steroidal anti-inflammatory drugs (NSAIDs) due to its pain-relieving and
Mahapatra S, Duggal S, Botros M, Guzma J, Hakim N, Badillo R.   +5 more
europepmc   +2 more sources

Assessing potential risk factors for metamizole-induced leukopenia

Therapeutic Advances in Drug Safety
Background: Metamizole is a non-opioid analgesic agent that can rarely cause agranulocytosis, a severe form of leukopenia. Objectives: The aim of this study was to assess previously identified potential risk factors for the development of metamizole ...
Birgit Brüne, Sarah Sonderer, Maria Bösing, Simona Hübner, Kanchan Dongre, Selina Späni, Andreas Holboro, Jörg D. Leuppi, Anne B. Leuppi-Taegtmeyer   +8 more
doaj   +2 more sources

Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

Biomedicines
The availability of metamizole varies greatly around the world. There are countries such as the USA, UK, or Australia where the use of metamizole is completely forbidden, and there are also countries where this drug is available only on prescription (e.g.
Dominik Poradowski, Aleksander Chrószcz, Radosław Spychaj, Joanna Wolińska, Vedat Onar   +4 more
doaj   +2 more sources

Risk Factors for Intolerable Postoperative Pain After Vitreoretinal Surgery Under AoA-Guided General Anesthesia with Intravenous COX-3 Inhibitors: A Post Hoc Analysis [PDF]

Pharmaceuticals
Background/Objectives: Intolerable postoperative pain perception (IPPP) may occur in patients undergoing vitreoretinal surgery (VRS), while general anesthesia (GA) is often preferred over regional techniques due to multiple contraindications ...
Michał J. Stasiowski, Kaja Marczak, Anita Lyssek-Boroń, Nikola Zmarzły   +3 more
doaj   +2 more sources

The Adequacy of Anesthesia Guidance for Vitreoretinal Surgeries with Preemptive Paracetamol/Metamizole

Pharmaceuticals
Despite the possibility of postoperative pain occurrence, in some patients, vitreoretinal surgeries (VRSs) require performance of general anesthesia (GA).
Michał Jan Stasiowski, Anita Lyssek-Boroń, Nikola Zmarzły, Kaja Marczak, Beniamin Oskar Grabarek   +4 more
doaj   +2 more sources