Results 21 to 30 of about 9,301 (237)

Potential Cytoprotective and Anti-Apoptotic Effect of Metamizole Alone and in Combination with Cytostatic Drugs Observed In Vitro in Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

Biomedicines
Metamizole (dipyrone) is still a frequently used drug in human and veterinary medicine, especially for pain relief, sometimes also in osteosarcoma treatment.
Dominik Poradowski, Aleksander Chrószcz, Radosław Spychaj, Vedat Onar   +3 more
doaj   +2 more sources

Maternal Analgesic Exposure and Fetal Ductal Constriction: A Prospective Cohort Study in Late Pregnancy. [PDF]

Birth Defects Res
ABSTRACT Objective To evaluate the association between maternal analgesic exposure in late pregnancy and fetal ductal and pulmonary hemodynamics using serial echocardiographic assessment, and to explore potential differences between metamizole and acetaminophen. Methods In this prospective cohort study, 67 third‐trimester pregnancies were evaluated: 47
Rocha IEGM, Nobre AC, Rocha BG, Siqueira PHB, Cândido EL, Brandão SCS.   +5 more
europepmc   +2 more sources

Proliferative effects of metamizole sodium on U-87 MG glioblastoma cell line: a pain killer or a killer? [PDF]

World Cancer Research Journal, 2021
OBJECTIVE: During cancer treatment, painkillers are often used to alleviate patient pain. Metamizole is a pyrazolone derivative and a non-opioid pain reliever.
O. Koçak, E. Şimşek
doaj   +1 more source

Interference of metamizole in the measurement of serum creatinine concentration

Advances in Laboratory Medicine
There is little literature on the interference of metamizole in measurement creatinine concentration by the enzymatic method. Some studies have postulated that the dipyrone molecule is responsible for interfering in the last reaction of the enzymatic ...
Castro-Castro María-José, Cachón-Suárez Isabel, Maestre-Fernández Andrea, Navarro-Badal Rosa   +3 more
doaj   +2 more sources

Effects of Metamizole, 4-Methylaminoantipyrine, and 4-Aminoantipyrine on LX-2 Liver Cell Line Viability and Apoptosis

Molecules
Metamizole (dipyrone) is a non-opioid analgesic widely used in human and veterinary medicine, despite ongoing concerns about its safety due to risks such as agranulocytosis and potential hepatotoxicity.
Georgiana-Iulia Lupu, Emoke Pall, Mihai Cenariu, Monica Irina Nan, Sanda Andrei   +4 more
doaj   +2 more sources

Adherence of NSAID Administration in Patients with Mild and Moderate Traumatic Brain Injury in Dr. Soetomo General Hospital, Surabaya

Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 2021
Introduction: Traumatic brain injury (TBI) has a concerning incidence rate. One of the therapies for patients with TBI is non-steroidal anti-inflammatory drugs (NSAID) administration as an analgesic with proper adherence to achieve optimal therapy ...
Finna Permata Putri, Agus Turchan, Nurmawati Fatimah, Muhtarum Yusuf   +3 more
doaj   +1 more source

Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

Drugs in R&D, 2023
Background and objective Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole.
Raphael Allgaier, Arne Kandulski, Karsten Gülow, Lars Maier, Martina Müller, Hauke Christian Tews   +5 more
doaj   +1 more source

Development of Fourier transform infrared spectrophotometric method for identification and determination of marketed metamizole tablet preparation

Jurnal Natural, 2021
Metamizole is a nonsteroidal antiinflammatory drug (NSAID) that functions as an analgesic, antipyretic, and antiinflammatory. Examination of active substance contents is a requirement that must be met to ensure the quality of drug preparations.
NERDY NERDY, EFFENDY DE LUX PUTRA, NILSYA FEBRIKA ZEBUA, CHRISTICA ILSANNA SURBAKTI, JIHAN SAFIRA   +4 more
doaj   +1 more source

Case series: Heinz body formation in 13 multimorbid dogs following metamizole administration

Frontiers in Veterinary Science, 2023
BackgroundHeinz Body (HB) anemia is a result of oxidative damage and is an uncommon condition in dogs relative to cats. In this retrospective case series, clinical features, laboratory values, concurrent diseases, and outcomes of 13 multimorbid dogs that
Vera Geisen, Katrin Hartmann, René Dörfelt   +2 more
doaj   +1 more source

Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study

Frontiers in Pharmacology, 2021
Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic effect
Lea S Blaser, Urs Duthaler, Urs Duthaler, Jamal Bouitbir, Jamal Bouitbir, Anne B Leuppi-Taegtmeyer, Anne B Leuppi-Taegtmeyer, Evangelia Liakoni, Reto Dolf, Michael Mayr, Jürgen Drewe, Stephan Krähenbühl, Stephan Krähenbühl, Stephan Krähenbühl, Manuel Haschke   +14 more
doaj   +1 more source