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Osteosarcoma and Metastasis [PDF]
Frontiers in Oncology, 2021 Osteosarcoma is the most common primary bone malignancy in adolescents. Its high propensity to metastasize is the leading cause for treatment failure and poor prognosis. Although the research of osteosarcoma has greatly expanded in the past decades, the knowledge and new therapy strategies targeting metastatic progression remain sparse.
Gaohong Sheng +3 more
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The Complexities of Metastasis [PDF]
Cancers, 2019 Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ...
Maria Jesus Garcia-Leon +9 more
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MicroRNAs and Metastasis [PDF]
Cancers, 2019 Metastasis, the development of secondary malignant growths at a distance from the primary site of a cancer, is associated with almost 90% of all cancer deaths, and half of all cancer patients present with some form of metastasis at the time of diagnosis. Consequently, there is a clear clinical need for a better understanding of metastasis.
Charles H. Lawrie +2 more
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Mechanisms of metastasis [PDF]
Breast Cancer Research, 2008 Metastasis is an enormously complex process that remains to be a major problem in the management of cancer. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex.
Kent W. Hunter +2 more
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Nature Reviews Cancer, 2013 Jeffrey Wrana and colleagues find that exosomes from cancer-associated fibroblasts activate WNT–planar cell polarity signalling in recipient breast tumour cells, which promotes motility and metastasis.
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International Journal of Molecular Sciences, 2023 Cancer metastasis is a common biological phenomenon observed in malignant tumors that can lead to death in affected individuals [...]
Masa-Aki Shibata, Kohei Taniguchi
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Nature Reviews Cancer, 2019 Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and melanoma, is associated with poor survival outcomes and poses distinct clinical challenges. The brain microenvironment, with its unique cell types, anatomical structures, metabolic constraints and immune environment, differs drastically from microenvironments of ...
Adrienne Boire +3 more
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Integrins and metastasis [PDF]
Cell Adhesion & Migration, 2013 Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and
Shuvojit Moulik +3 more
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Journal of Oral and Maxillofacial Pathology, 2017 Cancer is one of the most life threatening diseases afflicting mankind. Oral carcinogenesis is a multifactorial process involving numerous genetic events that alter normal functions of oncogenes and tumour suppressor genes. These changes lead to a cell phenotype with increased cell proliferation, with loss of cell cohesion, and infiltration of adjacent
Pallavi Shirol +3 more
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Cancer Research, 2011 Abstract Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of ...
Anita Wolfer, Sridhar Ramaswamy
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