Results 101 to 110 of about 1,034,096 (317)

Role of Post-Translational Modifications in Colorectal Cancer Metastasis

Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. CRC metastasis is a multi-step process with various factors involved, including genetic and epigenetic regulations, which turn out to be a serious threat to CRC ...
Yihong Liu, Haibo Zhao, Jingwei Liu, Weixin Liu, Shuangshuang Hai, Na Peng   +5 more
core   +1 more source

Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1 [PDF]

, 2012
Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread.
Susann Bruche, Machesky Laura M., Braga, VMM, Susann Bruche (175558), Machesky, LM, Vania M M Braga, Dawson, JC, John C Dawson, Heather J. Spence (175559), Machesky, L.M., Bruche Susann, Spence Heather J., Heather J Spence, Bruche, S., Vania M. M. Braga (175563), Braga, VM, John C. Dawson (175556), Braga Vania M. M., Spence, HJ, Spence, H.J., Laura M. Machesky (175567), Braga, V.M.M., Dawson, J.C., Laura M Machesky, Bruche, Susann, Bruche, S, Dawson John C.   +26 more
core   +1 more source

Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts

The EMBO Journal
Pancreatic adenocarcinoma (PAAD) cells exploit vesicle trafficking proteins, such as myoferlin (encoded by MYOF), to fuel tumor aggressiveness, yet the presence and function of myoferlin-dependent vesicles in cancer-associated fibroblasts (CAFs) remain ...
Raphaël Peiffer, Emilie Laverdeur, Anthoula Gaigneaux, Yasmine Boumahd, Charlotte Gullo, Gilles Rademaker, Rebekah Crake, Arnaud Lavergne, Naïma Maloujahmoum, Ferman Agirman, Michael Herfs, Atsushi Masamune, Elisabeth Letellier, Akeila Bellahcène, Olivier Peulen   +14 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Genome-Wide CRISPR Screen Identifies Genes Involved in Metastasis of Pancreatic Ductal Adenocarcinoma

Background/Objectives: Early and aggressive metastasis is a major feature of pancreatic ductal adenocarcinoma. Understanding the processes underlying metastasis is crucial for making a difference to disease outcome.
Haoqi Du, Risky Oktriani, Anna Chiara Pirona, Andrea S. Bauer, Lili Kalmár, Ariani S. Rahadian, Michael Boettcher, Beiping Miao, Jörg D. Hoheisel   +8 more
core   +1 more source

Correction: Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis

Oncogenesis, 2023
Gilles Rademaker, Brunella Costanza, Justine Bellier, Michael Herfs, Raphaël Peiffer, Ferman Agirman, Naïma Maloujahmoum, Yvette Habraken, Philippe Delvenne, Akeila Bellahcène, Vincent Castronovo, Olivier Peulen   +11 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Discovery of novel MKL1 target genes important for cancer progression and metastasis : a focus on WNT1 inducible signaling pathway protein 1 (WISP1/CCN4) [PDF]

, 2015
Tenascin-C (TNC) is involved in tumor initiation and metastasis, and high TNC expression has been associated with poor prognosis in cancers such as glioma, breast, colon and lung carcinoma (Orend and Chiquet-Ehrismann, 2006; Oskarsson, 2013).
Gürbüz, Irem
core   +1 more source

C/EBPβ Regulates HIF-1α-Driven Invasion of Non-Small-Cell Lung Cancer Cells

Biomolecules
Metastatic cancer accounts for most cancer-related deaths, and identifying specific molecular targets that contribute to metastatic progression is crucial for the development of effective treatments.
Seung Hee Seo, Ji Hae Lee, Eun Kyung Choi, Seung Bae Rho, Kyungsil Yoon   +4 more
doaj   +1 more source

THE MECHANISM OF METASTASIS

Orthopedic Clinics of North America, 2000
The establishment of clinically detectable skeletal metastasis is a multifactorial process. This process can be divided into three general areas of understanding. The first is that of the intrinsic characteristics and properties of the tumor cells, which allow and facilitate their migration from the site of primary neoplasia to the distant host ...
Department of Orthopaedic Surgery, Henry Ford Hospitals and Clinics, Detroit, Michigan (AM) ( host institution ), Mollabashy, Allaaddin, Scarborough, Mark   +2 more
openaire   +3 more sources