Results 81 to 90 of about 1,603,424 (366)

Prostate Cancer Lung Metastasis: Clinical Insights and Therapeutic Strategies [PDF]

Prostate cancer lung metastasis represents a clinical conundrum due to its implications for advanced disease progression and the complexities it introduces in treatment planning.
Ahmed M. Mahmoud, Daniel S. Childs, Bradley J. Stish, Brian J. Davis, Carter Day, Spyridon Basourakos, A. Tuba Kendi, Rimki Haloi, Mohamed E. Ahmed, Jacob J. Orme, Jack R. Andrews, Usama M. Marzouk, Wael Zeina, Eugene D. Kwon, Mindie Mahon, Miguel Muniz, Amr Moustafa, Irbaz Bin Riaz   +17 more
core   +1 more source

LncRNA LINC01094 Promotes Cells Proliferation and Metastasis through the PTEN/AKT Pathway by Targeting AZGP1 in Gastric Cancer [PDF]

, 2023
Long noncoding RNAs (lncRNAs) were recently reported to play an essential role in multiple cancer types. Herein, through next-generation sequencing, we screened metastasis-driving molecules by using tissues from early-stage gastric cancer (GC) patients ...
Yue Yang, Yanqiu Zhang, Yixuan Wang, Liqin Zhao, Yanan Yang, Jieyun Zhang, Nuoya Yu, Zhenhua Wu, Zhe Gong, Weijian Guo   +9 more
core   +1 more source

Tmem119 expression is downregulated in a subset of brain metastasis-associated microglia

BMC Neuroscience
Under pathological conditions, the immune-specialized brain microenvironment contains both resident microglia and bone marrow-derived myeloid cells recruited from peripheral circulation.
Weili Ma, Jack Oswald, Angela Rios Angulo, Qing Chen   +3 more
doaj   +1 more source

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Molecular Cancer, 2019
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance.
Ladan Mashouri, Hassan Yousefi, A. Aref, A. Ahadi, F. Molaei, S. Alahari   +5 more
semanticscholar   +1 more source

Long noncoding RNAs in cancer metastasis

Nature Reviews. Cancer, 2021
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a multistep process that occurs through the acquisition of molecular and phenotypic changes enabling cancer cells from a primary tumour to disseminate and colonize at ...
S. Liu, H. Dang, D. Lim, F. Feng, C. Maher   +4 more
semanticscholar   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Chromosomal instability drives metastasis through a cytosolic DNA response

Nature, 2018
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established.
S. Bakhoum, Bryan Ngo, Ashley M. Laughney, J. Cavallo, C. Murphy, P. Ly, Pragya Shah, Roshan K. Sriram, T. Watkins, Neil K. Taunk, Mercedes A. Duran, C. Pauli, Christine J. Shaw, Kalyani Chadalavada, Vinagolu K. Rajasekhar, G. Genovese, Subramanian Venkatesan, Nicolai J. Birkbak, N. Mcgranahan, Mark Lundquist, Q. LaPlant, J. Healey, O. Elemento, C. Chung, N. Y. Lee, Marcin Imielenski, G. Nanjangud, D. Pe’er, D. Cleveland, S. Powell, J. Lammerding, C. Swanton, L. Cantley   +32 more
semanticscholar   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Multi-Cancer Computational Analysis Reveals Metastasis-Associated Variant of Desmoplastic Reaction Involving INHBA and THBS2 [PDF]

, 2010
Despite extensive research, the details of the metastasis-associated biological mechanisms are largely unknown. Here, we analyze data from multiple cancers using a novel computational method identifying sets of genes whose coordinated overexpression ...
Vinay Varadan, Hoon Kim, John Watkinson, Dimitris Anastassiou   +3 more
core   +1 more source

Role of LncRNAs in regulating cancer amino acid metabolism

Cancer Cell International, 2021
The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished metabolic characteristics called metabolic ...
Yuhong Guo, Bin Lv, Renfeng Liu, Zhengzai Dai, Feifei Zhang, Yiping Liang, Bo Yu, Duo Zeng, Xiao-Bin Lv, Zhiping Zhang   +9 more
doaj   +1 more source