Results 11 to 20 of about 2,015,361 (384)
Cell, 2023 Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still emerging. Metastasis requires the acquisition of a succession of traits to disseminate, variably enter and exit dormancy, and colonize distant organs. The success of these
Stefanie, Gerstberger +2 more
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Cancer Cell, 2022 Metastasis, the major cause of cancer death, represents one of the major challenges in oncology. Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dormant for years, how they become resistant to the immune system or cytotoxic effects of systemic therapy ...
Lyden, David +11 more
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International Journal of Molecular Sciences, 2023 Cancer metastasis is a common biological phenomenon observed in malignant tumors that can lead to death in affected individuals [...]
Masa-Aki Shibata, Kohei Taniguchi
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Concepts of extracellular matrix remodelling in tumour progression and metastasis
Nature Communications, 2020 Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling.
Juliane Winkler +3 more
semanticscholar +1 more source
Molecular principles of metastasis: a hallmark of cancer revisited
Signal Transduction and Targeted Therapy, 2020 Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of ...
Jawad Fares +4 more
semanticscholar +1 more source
Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level.
Cancer Discovery, 2021 Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 matched samples by using single-cell RNA-seq and Spatial Transcriptomics.
Yingcheng Wu +20 more
semanticscholar +1 more source
Tumour exosome integrins determine organotropic metastasis
Nature, 2015 Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident ...
Ayuko Hoshino +53 more
semanticscholar +1 more source
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Journal of Hematology & Oncology, 2022 Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis,
Yuhe Huang, Weiqi Hong, Xiawei Wei
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Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
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Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Nature, 2010 Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood.
Rajnish A. Gupta +17 more
semanticscholar +1 more source