Results 11 to 20 of about 1,959,855 (381)
Cell, 2023 Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still emerging. Metastasis requires the acquisition of a succession of traits to disseminate, variably enter and exit dormancy, and colonize distant organs. The success of these
S. Gerstberger, Qingwen Jiang, K. Ganesh
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Osteosarcoma and Metastasis [PDF]
Frontiers in Oncology, 2021 Osteosarcoma is the most common primary bone malignancy in adolescents. Its high propensity to metastasize is the leading cause for treatment failure and poor prognosis. Although the research of osteosarcoma has greatly expanded in the past decades, the knowledge and new therapy strategies targeting metastatic progression remain sparse.
Gaohong Sheng +3 more
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Cancer Cell, 2022 Metastasis, the major cause of cancer death, represents one of the major challenges in oncology. Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dormant for years, how they become resistant to the immune system or cytotoxic effects of systemic therapy ...
Lyden, David +11 more
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The Complexities of Metastasis [PDF]
Cancers, 2019 Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ...
Maria Jesus Garcia-Leon +9 more
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The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Journal of Hematology & Oncology, 2022 Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis,
Yuhe Huang, Weiqi Hong, Xiawei Wei
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MicroRNAs and Metastasis [PDF]
Cancers, 2019 Metastasis, the development of secondary malignant growths at a distance from the primary site of a cancer, is associated with almost 90% of all cancer deaths, and half of all cancer patients present with some form of metastasis at the time of diagnosis. Consequently, there is a clear clinical need for a better understanding of metastasis.
Charles H. Lawrie +2 more
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Concepts of extracellular matrix remodelling in tumour progression and metastasis
Nature Communications, 2020 Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling.
Juliane Winkler +3 more
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Breast Cancer Metastasis: Mechanisms and Therapeutic Implications
International Journal of Molecular Sciences, 2022 Breast cancer is the most common malignancy in women worldwide. Metastasis is the leading cause of high mortality in most cancers. Although predicting the early stage of breast cancer before metastasis can increase the survival rate, breast cancer is ...
Misung Park +5 more
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Mechanisms of metastasis [PDF]
Breast Cancer Research, 2008 Metastasis is an enormously complex process that remains to be a major problem in the management of cancer. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex.
Kent W. Hunter +2 more
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Molecular principles of metastasis: a hallmark of cancer revisited
Signal Transduction and Targeted Therapy, 2020 Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of ...
Jawad Fares +4 more
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