Results 21 to 30 of about 1,137,655 (229)

Metastasis: To and fro

Journal of Oral and Maxillofacial Pathology, 2017
Cancer is one of the most life threatening diseases afflicting mankind. Oral carcinogenesis is a multifactorial process involving numerous genetic events that alter normal functions of oncogenes and tumour suppressor genes. These changes lead to a cell phenotype with increased cell proliferation, with loss of cell cohesion, and infiltration of adjacent
Pallavi Shirol, Jyoti B Alur, Prachi Baldawa, Venkatesh Kulkarni   +3 more
openaire   +4 more sources

Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis

Journal of Bone Oncology, 2019
Bone metastasis of cancer can be a result from systemic blood spreading or vertebral venous plexus spreading. Systemic blood pathway induced bone metastasis can happen in any bone in the body since the spreading is considered to be random. However, it remains unknown whether there is any pattern of vertebral venous plexus related bone metastasis.
Mingyu Zhu, Xin Liu, Yuan Qu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Huijuan Yang, Liangping Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhongwu Lu, Zhiguo Luo, Xichun Hu   +16 more
openaire   +3 more sources

Integrins and metastasis [PDF]

Cell Adhesion & Migration, 2013
Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and
Shuvojit Moulik, Kirat Kumar Ganguly, Amitava Chatterjee, Sekhar Pal   +3 more
openaire   +2 more sources

The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation. [PDF]

, 2016
Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated.
Chang, Hong-Tai, Chang, Yu-Chang, Chen, Chi-Long, Ger, Luo-Ping, Hsiao, Michael, Huang, Ming-Shyan, Jan, Yi-Hua, Lai, Tsung-Ching, Lin, Tsung-Chieh, Lin, Yuan-Feng, Liu, Yu-Peng, Pan, Wen-An, Shyy, John Y-J, Su, Chia-Yi, Tsai, Ming-Daw, Wu, Pei-Yu, Yang, Chih-Jen, Yeh, Chi-Tai   +17 more
core   +2 more sources

Selenoproteins and Metastasis [PDF]

, 2017
Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for antimetastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis.
Peter R. Hoffmann, Michael P. Marciel
openaire   +3 more sources

Systemic inflammation: Cancer's long-distance reach to maximize metastasis [PDF]

, 2015
While major improvements have been made in targeting primary tumor growth, metastasis and combating cancer spread remain an enigma. We recently identified a systemic inflammatory cascade involving IL17-producing γδ T cells and neutrophils that advance ...
Coffelt, Seth B., de Visser, Karin E.
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Breast Cancer Associated Metastasis is Significantly Increased in a Model of Autoimmune Arthritis [PDF]

, 2008
Chronic inflammation is known to play a role in cancer initiation, promotion,and metastasis. However, the mechanism by which inflammation promotes metastasis is still unclear.
Latha Pathangey, Lopamudra Das Roy, Pinku Mukherjee, Teresa Tinder   +3 more
core   +1 more source

Using of Binominal Method for the Purpose of Determination of Confidence Intervals for Prediction of Invasive Ductal Breast Carcinoma Metastases [PDF]

, 2016
The study was performed using surgical and biopsy material based on histopathological study, which was conducted at the Chernivtsy Regional Clinical Oncology Centre.
Davydenko, I. (Igor), Lazaruk, A. (Alexandr)   +1 more
core   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source