Results 21 to 30 of about 1,959,855 (381)

Tumour exosome integrins determine organotropic metastasis

Nature, 2015
Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident ...
Ayuko Hoshino, B. Costa-Silva, Tang-Long Shen, G. Rodrigues, Ayako Hashimoto, M. T. Mark, H. Molina, S. Kohsaka, Angela Di Giannatale, S. Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, K. Uryu, Lindsay A. Pharmer, T. King, L. Bojmar, A. E. Davies, Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan M. Hernandez, Joshua M. Weiss, Vanessa D. Dumont-Cole, K. Kramer, L. Wexler, A. Narendran, G. Schwartz, J. Healey, P. Sandstrom, K. Labori, E. Kure, P. Grandgenett, M. Hollingsworth, Maria de Sousa, S. Kaur, Maneesh Jain, K. Mallya, S. Batra, W. Jarnagin, M. Brady, O. Fodstad, V. Muller, K. Pantel, A. Minn, M. Bissell, B. Garcia, Yibin Kang, Vinagolu K Rajasekhar, Cyrus M. Ghajar, Irina R Matei, H. Peinado, J. Bromberg, D. Lyden   +53 more
semanticscholar   +1 more source

Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype

iScience, 2021
Summary: Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge.
Xue Hao, Bo Zhao, Wei Zhou, Heng Liu, Takeshi Fukumoto, Dmitry Gabrilovich, Rugang Zhang   +6 more
doaj   +1 more source

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

Nature, 2022
Aggressive and metastatic cancers show enhanced metabolic plasticity1, but the precise underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA methyltransferase 3 (NSUN3)-dependent RNA modifications—5-methylcytosine (m5C) and its ...
S. Delaunay, Gloria Pascual, B. Feng, Kevin Klann, Mikaela Behm, A. Hotz-Wagenblatt, Karsten Richter, K. Zaoui, E. Herpel, Christian Münch, S. Dietmann, J. Hess, S. Benitah, M. Frye   +13 more
semanticscholar   +1 more source

Polarizing metastasis [PDF]

Nature Reviews Cancer, 2013
Jeffrey Wrana and colleagues find that exosomes from cancer-associated fibroblasts activate WNT–planar cell polarity signalling in recipient breast tumour cells, which promotes motility and metastasis.
openaire   +3 more sources

Cellular and molecular mediators of bone metastatic lesions [PDF]

, 2018
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia, Del Fattore, Andrea, Marampon, Francesco, Rossi, Michela   +3 more
core   +2 more sources

Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Nature, 2010
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood.
Rajnish A. Gupta, Nilay Shah, Kevin C. Wang, Jeewon Kim, H. Horlings, D. Wong, Miao-Chih Tsai, T. Hung, P. Argani, J. Rinn, Yulei N. Wang, P. Brzoska, Benjamin S. Kong, Rui Li, R. West, M. J. van de Vijver, S. Sukumar, Howard Y. Chang   +17 more
semanticscholar   +1 more source

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

Nature Communications, 2021
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang   +13 more
doaj   +1 more source

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]

, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S, Balistreri, G, Gramolelli, S, Hautaniemi, S, Icay, K, Ivaska, J, Lehti, K, Niiranen, O, Ojala, PM, Paatero, I, Pekkonen, P, Perälä, N, Repo, P, Saharinen, P, Taiwo, A, Tatti-Bugaeva, O, Tuohinto, K, Zinovkina, N   +17 more
core   +1 more source

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]

, 2014
Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Aguilar-Guzmán, L, Bennett, DC, Bieneck, S, Burzio, V, Fernandez, JG, Hossain, M, Leyton, L, Lobos-Gonzalez, L, Muñoz, N, Quest, AF, Silva, V, Sviderskaya, EV   +11 more
core   +2 more sources

Evolution from small molecule to nano-drug delivery systems: An emerging approach for cancer therapy of ursolic acid

Asian Journal of Pharmaceutical Sciences, 2020
Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application ...
Jingwei Shao, Yifan Fang, Ruirui Zhao, Fangmin Chen, Mingyue Yang, Jiali Jiang, Zixuan Chen, Xiaotian Yuan, Lee Jia   +8 more
doaj   +1 more source