Results 21 to 30 of about 2,015,361 (384)
iScience, 2021 Summary: Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge.
Xue Hao +6 more
doaj +1 more source
Neural regulation of cancer: from mechanobiology to inflammation. [PDF]
, 2016 Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung +2 more
core +2 more sources
Breast Cancer Metastasis: Mechanisms and Therapeutic Implications
International Journal of Molecular Sciences, 2022 Breast cancer is the most common malignancy in women worldwide. Metastasis is the leading cause of high mortality in most cancers. Although predicting the early stage of breast cancer before metastasis can increase the survival rate, breast cancer is ...
Misung Park +5 more
semanticscholar +1 more source
Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]
, 2014 Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Aguilar-Guzmán, L +11 more
core +2 more sources
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Nature Communications, 2021 The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can ...
Jianhuang Lin +13 more
doaj +1 more source
Using of Binominal Method for the Purpose of Determination of Confidence Intervals for Prediction of Invasive Ductal Breast Carcinoma Metastases [PDF]
, 2016 The study was performed using surgical and biopsy material based on histopathological study, which was conducted at the Chernivtsy Regional Clinical Oncology Centre.
Davydenko, I. (Igor) +1 more
core +2 more sources
Asian Journal of Pharmaceutical Sciences, 2020 Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application ...
Jingwei Shao +8 more
doaj +1 more source
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]
, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S +17 more
core +1 more source
Neutrophils in cancer carcinogenesis and metastasis
Journal of Hematology & Oncology, 2021 In recent years, neutrophils have attracted increasing attention because of their cancer-promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic indicator for patients with cancer.
Shumin Xiong, Liaoliao Dong, Lin Cheng
semanticscholar +1 more source
STAR Protocols, 2023 Summary: Organotypic brain cultures are short-term assays that phenotypically and functionally recapitulate brain metastatic cells in vivo. Here, we present a protocol to generate murine organotypic brain cultures for drug screening.
Lucía Zhu +4 more
doaj +1 more source