Results 41 to 50 of about 1,229,811 (353)
The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation. [PDF]
, 2016 Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated.
Chang, Hong-Tai +17 more
core +2 more sources
Role of LncRNAs in regulating cancer amino acid metabolism
Cancer Cell International, 2021 The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished metabolic characteristics called metabolic ...
Yuhong Guo +9 more
doaj +1 more source
Primary Tumor and Inter-Organ Augmentations for Supervised Lymph Node Colon Adenocarcinoma Metastasis Detection [PDF]
arXiv, 2021 The scarcity of labeled data is a major bottleneck for developing accurate and robust deep learning-based models for histopathology applications. The problem is notably prominent for the task of metastasis detection in lymph nodes, due to the tissue's low tumor-to-non-tumor ratio, resulting in labor- and time-intensive annotation processes for the ...
arxiv
Systemic inflammation: Cancer's long-distance reach to maximize metastasis [PDF]
, 2015 While major improvements have been made in targeting primary tumor growth, metastasis and combating cancer spread remain an enigma. We recently identified a systemic inflammatory cascade involving IL17-producing γδ T cells and neutrophils that advance ...
Coffelt, Seth B., de Visser, Karin E.
core +1 more source
Hepatology Communications, 2020 Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen +10 more
doaj +1 more source
Targeting cellular senescence to combat cancer and ageing
Molecular Oncology, 2022 Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth ...
Chen Wang, Xue Hao, Rugang Zhang
doaj +1 more source
Hierarchy of Gene Expression Data is Predictive of Future Breast Cancer Outcome [PDF]
Phys. Biol. 10 (2013) 056006, 2014 We calculate measures of hierarchy in gene and tissue networks of breast cancer patients. We find that the likelihood of metastasis in the future is correlated with increased values of network hierarchy for expression networks of cancer-associated genes, due to correlated expression of cancer-specific pathways.
arxiv +1 more source
Advanced Science, 2022 Nanostructures made entirely of DNAs display great potential as chemotherapeutic drug carriers but so far cannot achieve sufficient clinic therapy outcomes due to off‐target toxicity. In this contribution, an aptamer‐embedded hierarchical DNA nanocluster
Weijun Wang +8 more
doaj +1 more source
Breast Cancer Associated Metastasis is Significantly Increased in a Model of Autoimmune Arthritis [PDF]
, 2008 Chronic inflammation is known to play a role in cancer initiation, promotion,and metastasis. However, the mechanism by which inflammation promotes metastasis is still unclear.
Latha Pathangey +3 more
core +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source