Results 81 to 90 of about 1,013,786 (315)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Temsirolimus for patients with metastatic renal cell carcinoma : outcomes in patients receiving temsirolimus within a compassionate use program in a tertiary referral center [PDF]

, 2014
Aim: Temsirolimus has shown efficacy as first-line treatment of patients with metastatic renal cell carcinoma and poor prognostic features. The efficacy of temsirolimus in other clinical settings, such as second-line therapy, is unclear.
Pascoe, Jennifer, Afshar, Mehran, Porfiri, Emilio, Whitmarsh, Sue, James, Nicholas D.   +4 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A validation of the Oswestry Spinal Risk Index [PDF]

, 2016
Purpose The purpose of this study was to validate the Oswestry Spinal Risk Index (OSRI) in an external population. The OSRI predicts survival in patients with metastatic spinal cord compression (MSCC).
Saeed, Mohammad, Verma, R., Siddique, Irfan, Stephenson, John, Gregory, J., Tambe, A., Sinclair, V., Whitehouse, S., Stephenson, J.   +8 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]

, 2013
Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
David Sánchez-Martín (264504), Luis Alvarez-Vallina, Ana M Alvarez-Méndez, Álvarez-Cienfuegos, Ana, Rojo, Federico, Ángel M. Cuesta (157092), Fernández-Periáñez, Rodrigo, Álvarez-Méndez, Ana M., Laura Sanz, Vanesa Alonso-Camino (157099), Luis Álvarez-Vallina (7509), Ana Álvarez-Cienfuegos (157105), Compte, Marta, Irene Guijarro-Muñoz, Rodrigo Fernández-Periáñez, Cuesta, Ángel M., Cuesta Martínez, Ángel, Vanesa Alonso-Camino, Molina-Privado, Irene, Marta Compte (7506), Irene Molina-Privado (443574), Álvarez-Vallina, Luis, Ana Alvarez-Cienfuegos, Sandra Zazo (443575), Irene Guijarro-Muñoz (157085), Alonso-Camino, Vanesa, Sánchez-Martín, David, Rodrigo Fernández-Periáñez (443573), Zazo, Sandra, Angel M Cuesta, Laura Sanz (157117), David Sánchez-Martín, Federico Rojo, Irene Molina-Privado, Federico Rojo (163971), Sandra Zazo, Ana M. Álvarez-Méndez (443576), Guijarro-Muñoz, Irene, Sanz, Laura, Marta Compte, Rojo Todo, Federico Gustavo   +40 more
core   +1 more source

Contrast-enhanced ultrasound for the differential diagnosis between benign and metastatic superficial lymph nodes: a meta-analysis

Cancer Management and Research, 2018
Mei Mei,1 Ligang Ye,2 Juan Quan,1 Pintong Huang1 1Department of Ultrasound, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China; 2Department of Emergency, The Second Affiliated Hospital, Zhejiang University ...
Mei M, Ye LG, Quan J, Huang PT
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A systematic review of evidence on malignant spinal metastases : natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression [PDF]

, 2013
Background: Spinal metastases can lead to significant morbidity and reduction in quality of life due to spinal cord compression (SCC). Between 5% and 20% of patients with spinal metastases develop metastatic spinal cord compression during the course of ...
M Connock, D Shyangdan, Shyangdan, D., Court, Rachel A., Kandala, Ngianga-Bakwin, P Sutcliffe, R Court, N-B Kandala, Sutcliffe, P. (Paul), Connock, M., A Clarke, Clarke, Aileen   +11 more
core   +1 more source

Changing landscape of first-line treatment for locally advanced or metastatic urothelial carcinoma: the progression from platinum-based chemotherapy to platinum-free therapy

Frontiers in Immunology
Urothelial carcinoma (UC) represents the most common pathological type of bladder cancer. For patients with locally advanced or metastatic UC (la/m UC), the standard of care with platinum-based chemotherapy as the cornerstone has greatly improved the ...
Zengguang Liu, Chen Chen, Jiaxin Yin, Xiaofeng Cong, Ziling Liu   +4 more
doaj   +1 more source