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Metastatic breast cancer cells are selectively dependent on the mitochondrial cristae-shaping protein OPA1 [PDF]
In breast cancer, the inner mitochondrial membrane fusion protein Optic Atrophy 1 (OPA1) is upregulated and its inhibition reverses acquired chemoresistance. However, it remains unclear whether OPA1 inhibition also targets normal breast cells.
Antigoni Diokmetzidou+5 more
doaj +2 more sources
Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]
Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa+12 more
core +17 more sources
Abscopal Effect Following Cryoablation in a Patient with Metastatic Breast Cancer
While breast cancer is a common disease with many available treatment options, many patients still have limited responses, especially those with metastatic breast cancer. Surgery of the primary tumor or metastatic sites is often not part of the treatment
Jamie L. Kaplan+3 more
doaj +1 more source
Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells
Aberrant alternative splicing (AS) is a hallmark of cancer and a potential target for novel anti-cancer therapeutics. Breast cancer-associated AS events are known to be linked to disease progression, metastasis, and survival of breast cancer patients. To
Jagyeong Oh+10 more
doaj +1 more source
Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. [PDF]
Bone metastasis is a lethal and morbid late stage of breast cancer that is currently treatment resistant. More effective mouse models and treatment are necessary.
Bouvet, Michael+13 more
core +6 more sources
Background International consensus guidelines recommend patients with metastatic breast cancer have access to a nurse experienced in the treatment of metastatic breast cancer. This study aimed to explore women’s experiences of supportive care from breast
Andrea L. Smith+2 more
doaj +1 more source
Metastasis: A Bane of Breast Cancer Therapy
The underlying mechanisms of metastasis in patients with breast cancer is still poorly understood. Approximately 6% of patients with breast cancer present with metastasis at the time of diagnosis.
Chidalu A. Edechi,+4 more
doaj +1 more source
Prognostic factors and survival outcomes according to tumor subtype in patients with breast cancer lung metastases [PDF]
Background Reports on the incidence and prognoses of lung metastases when diagnosing breast cancer patients with different subtypes are limited. Our study investigated the effect of molecular sub-typing stratification on the prognoses of lung metastatic ...
Siying Chen+5 more
doaj +2 more sources
The management of locally advanced and metastatic breast cancer has evolved since 2021, with confirmation of the role of cell cycle inhibitors.The discovery of breast cancer is often the result of self-examination through the discovery of a nodule, but ...
Hammou El Farhaoui+5 more
doaj +1 more source
Chemotherapy for metastatic breast cancer [PDF]
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Barni S, Mandala' M
openaire +4 more sources