Results 261 to 270 of about 554,810 (355)

Survival Outcomes and Prognostic Factors of Metastatic Breast Cancer in Elderly Women: A Retrospective Study in Northeastern Morocco. [PDF]

Cureus
Maadin K, Majd H, Demnati Sadki N, Saoudi MT, El Meliani O, Amaadour L, Oualla K, Benbrahim Z, Mellas N, Arifi S.   +9 more
europepmc   +1 more source

Metastatic secretory breast cancer. Non-responsiveness to chemotherapy: Case report and review of the literature

, 2000
Helen Herz, B. Cooke, David Goldstein
openalex   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Precision therapy in metastatic breast cancer: the current landscape of molecular alteration-based therapies. [PDF]

Transl Breast Cancer Res
Abdullah HMA, Chennapragada SS, Singh R, Zeidalkilani JMJ, Kesireddy M.   +4 more
europepmc   +1 more source

Tumor lysis syndrome following hemi-body irradiation for metastatic breast cancer

, 2000
A.Y. Rostom, G. El-Hussainy, Alaa A. Kandil, Ayman Allam   +3 more
openalex   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Chromatin signalling pathways and FANCE amplification affect ATR inhibitor sensitivity in metastatic breast cancer

Selvarajah J, Fernandes R, Lorentzen M, Pei E, Greenland K, Kozik Z, Choudhary J, Bevan C.   +7 more
europepmc   +1 more source

Cost-effectiveness analysis of CDK4/6 inhibitors in the second-line treatment for HR+/HER2- advanced or metastatic breast cancer. [PDF]

Front Pharmacol
Wang K, Liu S, Li S, Gao J.
europepmc   +1 more source

Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model

, 2000
Anish Sen Majumdar, Alya Zolotorev, Sara Samuel, Kimvan Tran, Beth Vertin, Melinda Hall-Meier, Beth-Ann Antoni, Emmanuelle Adeline, Mohan Philip, Ramila Philip   +9 more
openalex   +1 more source

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

Advanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li, Ping Deng, Tengfei Fan, Yuchen Qu, Miduo Tan, Yidan Liang, Peng Gao, Yongchun Peng, Mingke Qin, Sheng Jie, Rongrong Hao, Liting Wang, Lei Zhang, Chunhai Chen, Mindi He, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Rui Tian, Min Li, Zhengping Yu, Zhou Zhou, Huifeng Pi   +24 more
wiley   +1 more source