Results 21 to 30 of about 541,156 (189)
Background Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor progression and/or drug resistance.
Toshiaki Akahane +6 more
doaj +1 more source
Biopsy confirmation of metastatic sites in breast cancer patients:clinical impact and future perspectives [PDF]
Determination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome,and the choice of therapy ...
A Santinelli +69 more
core +5 more sources
Role of
Background The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is critical for designing therapeutic modalities for reducing the occurrence of ...
Couraud Pierre-Olivier +6 more
doaj +1 more source
Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy [PDF]
Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent ...
Classen, S. +5 more
core +1 more source
Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]
Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana +5 more
core +1 more source
Conquering Metastatic Breast Cancer [PDF]
The plight of women (and men) with metastatic breast cancer and our wish to improve on our current inability to effect long-term cures for these patients are in our thoughts. Metastatic breast cancer is the top cancer killer for US women younger than 54 years of age, and some 40,000 individuals succumb each year in the United States, accounting for ...
openaire +2 more sources
Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics
Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in
Shao Thing Teoh +6 more
doaj +1 more source
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi +32 more
core +2 more sources
Background Eribulin mesylate (ERI; Halaven®) is a microtubule inhibitor approved in the United States for metastatic breast cancer patients with at least two prior chemotherapy regimens for metastatic breast cancer, and in the European Union in locally ...
Qi Zhao +7 more
doaj +1 more source
Stratification and therapeutic potential of PML in metastatic breast cancer [PDF]
Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood.
Aldaz, Paula +38 more
core +2 more sources

