Results 21 to 30 of about 541,156 (189)

Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions

BMC Cancer, 2020
Background Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor progression and/or drug resistance.
Toshiaki Akahane, Naoki Kanomata, Oi Harada, Tetsumasa Yamashita, Junichi Kurebayashi, Akihide Tanimoto, Takuya Moriya   +6 more
doaj   +1 more source

Biopsy confirmation of metastatic sites in breast cancer patients:clinical impact and future perspectives [PDF]

, 2014
Determination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome,and the choice of therapy ...
A Santinelli, AJ Montero, Alastair M Thompson, AM Thompson, Angela Esposito, Aron Goldhirsch, B Weigelt, BG Mobbs, C Liedtke, C Simmons, C Tapia, CA Gomez-Roca, Carmen Criscitiello, CH Lu, D Gancberg, DS Seah, E Amir, E Amir, E Brogi, EA Mittendorf, EA Perez, EA Perez, EE Lower, EE Lower, F Andre, F André, F Liebens, Fabrice André, Franco Orsi, G Aurilio, G Bogina, G Curigliano, G Viale, Giuseppe Curigliano, HJ Chang, Ida Minchella, J Carlsson, JM Wu, L Ding, L Pusztai, LD Hoefnagel, LM Bender, LS Lindstrom, LS Steelman, Luca Fumagalli, Lucia Gelao, M Scaltriti, Marzia Locatelli, Michele De Laurentiis, MJ Higgins, N Niikura, PJ Stephens, PK Idirisinghe, R Fisher, R Simon, RJ Broom, RJ Leary, S Gupta, S Vignot, SJ Aitken, SM Edgerton, SP Shah, ST Wong, T Forshew, U Wilking, V Guarneri, W Onstenk, Y Gong, Y Nagata, YM Lo   +69 more
core   +5 more sources

Role of KCNMA1 gene in breast cancer invasion and metastasis to brain

BMC Cancer, 2009
Background The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is critical for designing therapeutic modalities for reducing the occurrence of ...
Couraud Pierre-Olivier, Romero Ignacio A, Meister Edward A, Weksler Babette, Sankpal Umesh T, Khaitan Divya, Ningaraj Nagendra S   +6 more
doaj   +1 more source

Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy [PDF]

, 2002
Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent ...
Classen, S., Eiermann, W., Kopp, R., Possinger, K., Weidenhagen, R., Wilmanns, W.   +5 more
core   +1 more source

Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]

, 2019
Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana, Hesse, Eric, Pamperin, Jenny, Saito, Hiroaki, Schröder, Saskia, Taipaleenmäki, Hanna   +5 more
core   +1 more source

Conquering Metastatic Breast Cancer [PDF]

Journal of Oncology Practice, 2016
The plight of women (and men) with metastatic breast cancer and our wish to improve on our current inability to effect long-term cures for these patients are in our thoughts. Metastatic breast cancer is the top cancer killer for US women younger than 54 years of age, and some 40,000 individuals succumb each year in the United States, accounting for ...
openaire   +2 more sources

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics

Frontiers in Oncology, 2018
Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in
Shao Thing Teoh, Martin P. Ogrodzinski, Martin P. Ogrodzinski, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Sophia Y. Lunt   +6 more
doaj   +1 more source

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi, AD Borowsky, AJ Minn, AM Havens, B Brandt, B Qian, Bin-Zhi Qian, BS Nielsen, DR Getts, DR Rhodes, Elizabeth A. Kaiser, F Geissmann, F Geissmann, F Geissmann, FK Swirski, H Saji, HP Gerber, Hui Zhang, Jeffrey W. Pollard, JH Im, Jinghang Zhang, Jiufeng Li, JM Carton, Liam R. Campion, Linda A. Snyder, MD Abramoff, P Stern, P Tsui, RT Palframan, T Ueno, T Valkovic, Takanori Kitamura, Y Huang   +32 more
core   +2 more sources

Network meta-analysis of eribulin versus other chemotherapies used as second- or later-line treatment in locally advanced or metastatic breast cancer

BMC Cancer, 2021
Background Eribulin mesylate (ERI; Halaven®) is a microtubule inhibitor approved in the United States for metastatic breast cancer patients with at least two prior chemotherapy regimens for metastatic breast cancer, and in the European Union in locally ...
Qi Zhao, Rachel Hughes, Binod Neupane, Kristin Mickle, Yun Su, Isabelle Chabot, Marissa Betts, Ananth Kadambi   +7 more
doaj   +1 more source

Stratification and therapeutic potential of PML in metastatic breast cancer [PDF]

, 2016
Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood.
Aldaz, Paula, Anguita, Juan, Aransay, Ana M., Arreal, Leire, Arruabarrena-Aristorena, Amaia, Barrio, Rosa, Baselga Torres, Josep, 1959-, Caldas, Carlos, Caro Maldonado, Alfredo, Carracedo, Arkaitz, Cortazar, Ana Rosa, Domenici, Giacomo, Fernández-Ruiz, Sonia, Garcia, Stephane, Gomis i Cabré, Roger, Guiu, Marc, Ibrahim, Yasir H., Iovanna, Juan L., Lawrie, Charles H., Macías, Iratxe, Martín-Martín, Natalia, Martínez Chantar, Maria Luz, Matheu, Ander, Piva, Marco, Planet, Evarist, Radosevic Robin, Nina, Rueda, Oscar M., Salvador, Fernando, Scaltriti, Maurizio, Serra Elizalde, Violeta, Sutherland, James David, Sánchez Mosquera, Pilar, Torrano, Verónica, Urosevic, Jelena, Valcarcel-Jimenez, Lorea, Varela Rey, Marta, Vivanco, Maria d. M., Zabala Letona, Amaia, Zúñiga García, Patricia   +38 more
core   +2 more sources