Stratification and therapeutic potential of PML in metastatic breast cancer [PDF]
, 2016 Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood.
Aldaz, Paula +38 more
core +2 more sources
Emerging Intrinsic Therapeutic Targets for Metastatic Breast Cancer
Biology, 2023 Breast cancer is now the most common cancer worldwide, and it is also the main cause of cancer-related death in women. Survival rates for female breast cancer have significantly improved due to early diagnosis and better treatment.
Jiawei Li +7 more
doaj +1 more source
Metastatic Breast Cancer to the Urinary Bladder in the Caribbean
Case Reports in Oncology, 2021 One of the most common cancers amongst women is breast cancer. The most common metastatic sites are the lymph nodes, lungs, liver, and bone. Metastatic spread to the urinary bladder is rare, and this case, as far as we are aware, is the first reported in
Saara Mohammed, Atiba Akii Bua
doaj +1 more source
Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes [PDF]
, 2012 mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes.
Baretton, Gustavo +10 more
core +1 more source
Metastatic breast cancer: an updating
Biomedicine & Pharmacotherapy, 2006 This article reports on recent advances on metastatic breast cancer. Detection, prognostic factors, predictors of response to therapy and therapy, with particular regard to targeted therapies, were examined.Unlike current guidelines that yet do not routinely recommend intensive clinical-instrumental post-operative follow-up of breast cancer patients ...
NICOLINI, ANDREA +10 more
openaire +5 more sources
Pain in metastatic breast cancer [PDF]
Cancer, 1983 The pain experiences of 86 women with metastatic carcinoma of the breast were systematically evaluated over a period of one year. Fifty-six percent of the sample reported experiencing pain, and the intensity of pain was not significantly related to site of metastasis. Multiple regression analysis revealed that 50% of the variance in the pain experience
Joan R. Bloom, David Spiegel
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HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer. [PDF]
, 2016 BackgroundHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer is a particularly aggressive form of the disease, and ultimately progresses in patients with metastases on standard therapies.
Cortes, Javier +10 more
core +2 more sources
Hierarchy of Gene Expression Data is Predictive of Future Breast Cancer Outcome [PDF]
, 2013 We calculate measures of hierarchy in gene and tissue networks of breast cancer patients. We find that the likelihood of metastasis in the future is correlated with increased values of network hierarchy for expression networks of cancer-associated genes,
Chen, Man, Deem, Michael W.
core +1 more source
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
eLife, 2022 Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease.
Wesley L Cai +18 more
doaj +1 more source
Melatonin Does Not Alter Cell Proliferation in Metastatic Breast Cancer Cells
Proceedings, 2018 Breast cancer treatments continue to be investigated with supported by new treatment methods. Melatonin is a hormone that can be effective in the treatment of breast cancer due to its anti-oxidant effect.
Gamze Tanriover +2 more
doaj +1 more source