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A Cross-sectional Study on Prevalence of Vitamin B12 Deficiency and Peripheral Neuropathy between Metformin Users and Non Users in Participants with Type 2 Diabetes Mellitus [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Metformin is a first line drug for treatment of Type 2 Diabetes Mellitus (T2DM) which acts by decreasing insulin resistance. Metformin use can lead to vitamin B12 deficiency.
CA Jayashankar +5 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Metformin as an oral glucose-lowering drug is used to treat type 2 diabetic mellitus. Considering the relatively high incidence of cardiovascular complications and other metabolic diseases in diabetic mellitus patients, a combination of metformin plus ...
Choong Whan Lee +15 more
doaj +1 more source
Metformin: update on mechanisms of action and repurposing potential
Nature Reviews Endocrinology, 2023 Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients.
M. Foretz, B. Guigas, B. Viollet
semanticscholar +1 more source
Low-dose metformin targets the lysosomal AMPK pathway through PEN2
Nature, 2022 Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action 4 , 5 ...
Teng Ma +34 more
semanticscholar +1 more source