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Role of AMP-activated protein kinase in mechanism of metformin action [PDF]

open access: bronzeJournal of Clinical Investigation, 2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin's beneficial effects
Gaochao Zhou   +13 more
openalex   +2 more sources

Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1 [PDF]

open access: yesPharmaceuticals
Background: Besides diabetes mellitus, metformin has been identified as a potential therapeutic agent for treating various other conditions that include various cancers, cardiovascular diseases, neurodegenerative diseases, and aging. In cancer, metformin
Anna Shteinfer-Kuzmine   +6 more
doaj   +2 more sources

A Cross-sectional Study on Prevalence of Vitamin B12 Deficiency and Peripheral Neuropathy between Metformin Users and Non Users in Participants with Type 2 Diabetes Mellitus [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2021
Introduction: Metformin is a first line drug for treatment of Type 2 Diabetes Mellitus (T2DM) which acts by decreasing insulin resistance. Metformin use can lead to vitamin B12 deficiency.
CA Jayashankar   +5 more
doaj   +1 more source

Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract

open access: yesFrontiers in Pharmacology, 2023
Metformin as an oral glucose-lowering drug is used to treat type 2 diabetic mellitus. Considering the relatively high incidence of cardiovascular complications and other metabolic diseases in diabetic mellitus patients, a combination of metformin plus ...
Choong Whan Lee   +15 more
doaj   +1 more source

Metformin: update on mechanisms of action and repurposing potential

open access: yesNature Reviews Endocrinology, 2023
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients.
M. Foretz, B. Guigas, B. Viollet
semanticscholar   +1 more source

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

open access: yesNature, 2022
Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action 4 , 5 ...
Teng Ma   +34 more
semanticscholar   +1 more source

Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress

open access: yesFrontiers in Cell and Developmental Biology, 2022
Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response
Jane L. Tarry-Adkins   +12 more
doaj   +1 more source

Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes. [PDF]

open access: yesPLoS ONE, 2018
OBJECTIVE:Metformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to ...
Robert R Henry   +8 more
doaj   +1 more source

A study on metformin-induced anemia using red blood cell indices and red cell distribution width

open access: yesAssam Journal of Internal Medicine, 2023
Background: Diabetic patients on metformin may have increased risk of developing anemia. Hematological parameters can easily reflect anisocytosis and differential analysis of anemia.
Sasank Lingam   +2 more
doaj   +1 more source

Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin

open access: yesMolecules, 2021
Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects.
Sherin Abdelrahman   +5 more
doaj   +1 more source

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