Results 1 to 10 of about 186,082 (259)

Role of AMP-activated protein kinase in mechanism of metformin action [PDF]

Journal of Clinical Investigation, 2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin's beneficial effects
Gaochao Zhou, Robert P. Myers, Ying Li, Yuli Chen, Xiaolan Shen, Judy Fenyk‐Melody, Margaret Wu, John Ventre, Thomas W. Doebber, Nobuharu Fujii, Nicolas Musi, Michael F. Hirshman, Laurie J. Goodyear, David E. Moller   +13 more
openalex   +2 more sources

A Cross-sectional Study on Prevalence of Vitamin B12 Deficiency and Peripheral Neuropathy between Metformin Users and Non Users in Participants with Type 2 Diabetes Mellitus [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Metformin is a first line drug for treatment of Type 2 Diabetes Mellitus (T2DM) which acts by decreasing insulin resistance. Metformin use can lead to vitamin B12 deficiency.
CA Jayashankar, RashikaSah, VenkataBharat Kumar Pinnelli, Sourabh Hiremath, Dwarakanathan Vignesh, Obulapu Supraja   +5 more
doaj   +1 more source

Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract

Frontiers in Pharmacology, 2023
Metformin as an oral glucose-lowering drug is used to treat type 2 diabetic mellitus. Considering the relatively high incidence of cardiovascular complications and other metabolic diseases in diabetic mellitus patients, a combination of metformin plus ...
Choong Whan Lee, Byoung Hoon You, Sreymom Yim, Seung Yon Han, Hee-Sung Chae, Hee-Sung Chae, Mingoo Bae, Seo-Yeon Kim, Jeong-Eun Yu, Jieun Jung, Piseth Nhoek, Hojun Kim, Han Seok Choi, Young-Won Chin, Hyun Woo Kim, Young Hee Choi   +15 more
doaj   +1 more source

Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin

Molecules, 2021
Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects.
Sherin Abdelrahman, Mawadda Alghrably, Marcello Campagna, Charlotte Armgard Emma Hauser, Mariusz Jaremko, Joanna Izabela Lachowicz   +5 more
doaj   +1 more source

Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress

Frontiers in Cell and Developmental Biology, 2022
Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response
Jane L. Tarry-Adkins, India G. Robinson, Rebecca M. Reynolds, Irving L. M. H. Aye, Irving L. M. H. Aye, D. Stephen Charnock-Jones, D. Stephen Charnock-Jones, Benjamin Jenkins, Albert Koulmann, Susan E. Ozanne, Catherine E. Aiken, Catherine E. Aiken, Catherine E. Aiken   +12 more
doaj   +1 more source

Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes. [PDF]

PLoS ONE, 2018
OBJECTIVE:Metformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to ...
Robert R Henry, Juan P Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A Bicsak, Alain Baron, Mark Fineman   +8 more
doaj   +1 more source

Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport

International Journal of Molecular Sciences, 2022
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. There is a well-documented correlation between glucose transporter 4
R. Herman, N. Kravos, M. Jensterle, A. Janež, V. Dolžan   +4 more
semanticscholar   +1 more source

Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan

BMJ Open Diabetes Research & Care, 2020
Objective To assess the prevalence of vitamin B12 deficiency in people with type 2 diabetes mellitus (T2DM) on metformin and without metformin.Methodology Between May 2018 and January 2019, this prospective multicenter observational study recruited ...
Asher Fawwad, Nazish Waris, Bilal Tahir, Sobia Sabir Ali, Qazi Masroor, Salma Tanveer, Jamal Zafar, Zahid Miyan, Khalid Usman, Khursheed Ahmed, Riaz A Malik   +10 more
doaj   +1 more source

Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model

BMJ Open Diabetes Research & Care, 2020
Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy.
Daan J Touw, Henri G D Leuvenink, Rene A Posma, Leonie H Venema, Tobias M Huijink, Andrie C Westerkamp, A Mireille A Wessels, Nynke J De Vries, Frank Doesburg, J Roggeveld, Petra J Ottens, Maarten W Nijsten   +11 more
doaj   +1 more source

Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study

Clinical and Translational Science, 2021
The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously ...
Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen   +8 more
doaj   +1 more source