Results 1 to 10 of about 302,269 (383)

Comparative effectiveness of combining antidiabetic medications to treat renal impairment in patients with type 2 diabetes mellitus [PDF]

Scientific Reports
The comparative renoprotective effects of metformin-GLP-1 RA (glucagon-like peptide 1 receptor agonist), metformin-DPP-4i (dipeptidyl peptidase 4 inhibitor) and metformin-oADM (other antidiabetes medication) in patients with DKD (diabetic kidney disease)
Qiu Mo, Terrence J. Adam, Steven G. Johnson, Amir Moheet, David S. Pieczkiewicz   +4 more
doaj   +2 more sources

Metformin in 2019.

JAMA, 2019
Metformin is the first-line pharmacologic treatment for type 2 diabetes and the most commonly prescribed drug for this condition worldwide, either alone or in combination with insulin or other glucose-lowering therapies.
J. Flory, K. Lipska
semanticscholar   +5 more sources

Role of AMP-activated protein kinase in mechanism of metformin action [PDF]

Journal of Clinical Investigation, 2001
Gaochao Zhou, Robert P. Myers, Ying Li, Yuli Chen, Xiaolan Shen, Judy Fenyk‐Melody, Margaret Wu, John Ventre, Thomas W. Doebber, Nobuharu Fujii, Nicolas Musi, Michael F. Hirshman, Laurie J. Goodyear, David E. Moller   +13 more
openalex   +2 more sources

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain [PDF]

Biochemical Journal, 2000
Mark R. Owen, E. Doran, Andrew P. Halestrap   +2 more
semanticscholar   +3 more sources

A Cross-sectional Study on Prevalence of Vitamin B12 Deficiency and Peripheral Neuropathy between Metformin Users and Non Users in Participants with Type 2 Diabetes Mellitus [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Metformin is a first line drug for treatment of Type 2 Diabetes Mellitus (T2DM) which acts by decreasing insulin resistance. Metformin use can lead to vitamin B12 deficiency.
CA Jayashankar, RashikaSah, VenkataBharat Kumar Pinnelli, Sourabh Hiremath, Dwarakanathan Vignesh, Obulapu Supraja   +5 more
doaj   +1 more source

Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract

Frontiers in Pharmacology, 2023
Metformin as an oral glucose-lowering drug is used to treat type 2 diabetic mellitus. Considering the relatively high incidence of cardiovascular complications and other metabolic diseases in diabetic mellitus patients, a combination of metformin plus ...
Choong Whan Lee, Byoung Hoon You, Sreymom Yim, Seung Yon Han, Hee-Sung Chae, Hee-Sung Chae, Mingoo Bae, Seo-Yeon Kim, Jeong-Eun Yu, Jieun Jung, Piseth Nhoek, Hojun Kim, Han Seok Choi, Young-Won Chin, Hyun Woo Kim, Young Hee Choi   +15 more
doaj   +1 more source

Metformin: update on mechanisms of action and repurposing potential

Nature Reviews Endocrinology, 2023
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients.
M. Foretz, B. Guigas, B. Viollet
semanticscholar   +1 more source

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
AN Macintyre, AS Green, Benoit Viollet, C Grimaldi, David K. Finlay, DG Hardie, Doreen A. Cantrell, EL Pearce, EL Pearce, GD Holman, I Ben Sahra, JD Powell, K Araki, LV Sinclair, M Foretz, M Zarrouk, Marc Foretz, Marouan Zarrouk, MR Owen, N Nath, N Zhang, NJ MacIver, NJ MacIver, P Tamas, Ping Song, R Wang, R Wang, RA Miller, RD Michalek, S He   +29 more
core   +10 more sources

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Nature, 2022
Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action 4 , 5 ...
Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Q. Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, L. Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhichao Wang, Mingliang Zhang, Y. Bao, W. Jia, Shuyong Lin, Zhiyun Ye, Hai-long Piao, Xianming Deng, Chensong Zhang, Sheng-Cai Lin   +34 more
semanticscholar   +1 more source

Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress

Frontiers in Cell and Developmental Biology, 2022
Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response
Jane L. Tarry-Adkins, India G. Robinson, Rebecca M. Reynolds, Irving L. M. H. Aye, Irving L. M. H. Aye, D. Stephen Charnock-Jones, D. Stephen Charnock-Jones, Benjamin Jenkins, Albert Koulmann, Susan E. Ozanne, Catherine E. Aiken, Catherine E. Aiken, Catherine E. Aiken   +12 more
doaj   +1 more source