Results 1 to 10 of about 113,291 (133)

A Cross-sectional Study on Prevalence of Vitamin B12 Deficiency and Peripheral Neuropathy between Metformin Users and Non Users in Participants with Type 2 Diabetes Mellitus [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Metformin is a first line drug for treatment of Type 2 Diabetes Mellitus (T2DM) which acts by decreasing insulin resistance. Metformin use can lead to vitamin B12 deficiency.
CA Jayashankar, RashikaSah, VenkataBharat Kumar Pinnelli, Sourabh Hiremath, Dwarakanathan Vignesh, Obulapu Supraja   +5 more
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Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract

Frontiers in Pharmacology, 2023
Metformin as an oral glucose-lowering drug is used to treat type 2 diabetic mellitus. Considering the relatively high incidence of cardiovascular complications and other metabolic diseases in diabetic mellitus patients, a combination of metformin plus ...
Choong Whan Lee, Byoung Hoon You, Sreymom Yim, Seung Yon Han, Hee-Sung Chae, Hee-Sung Chae, Mingoo Bae, Seo-Yeon Kim, Jeong-Eun Yu, Jieun Jung, Piseth Nhoek, Hojun Kim, Han Seok Choi, Young-Won Chin, Hyun Woo Kim, Young Hee Choi   +15 more
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Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress

Frontiers in Cell and Developmental Biology, 2022
Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response
Jane L. Tarry-Adkins, India G. Robinson, Rebecca M. Reynolds, Irving L. M. H. Aye, Irving L. M. H. Aye, D. Stephen Charnock-Jones, D. Stephen Charnock-Jones, Benjamin Jenkins, Albert Koulmann, Susan E. Ozanne, Catherine E. Aiken, Catherine E. Aiken, Catherine E. Aiken   +12 more
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A study on metformin-induced anemia using red blood cell indices and red cell distribution width

Assam Journal of Internal Medicine, 2023
Background: Diabetic patients on metformin may have increased risk of developing anemia. Hematological parameters can easily reflect anisocytosis and differential analysis of anemia.
Sasank Lingam, Himavathy Kodandarao Gara, Dharma Rao Vanamali   +2 more
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Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin

Molecules, 2021
Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects.
Sherin Abdelrahman, Mawadda Alghrably, Marcello Campagna, Charlotte Armgard Emma Hauser, Mariusz Jaremko, Joanna Izabela Lachowicz   +5 more
doaj   +1 more source

Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model

BMJ Open Diabetes Research & Care, 2020
Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy.
Daan J Touw, Henri G D Leuvenink, Rene A Posma, Leonie H Venema, Tobias M Huijink, Andrie C Westerkamp, A Mireille A Wessels, Nynke J De Vries, Frank Doesburg, J Roggeveld, Petra J Ottens, Maarten W Nijsten   +11 more
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Erectile dysfunction as a possible important side effect of metformin: A case report [PDF]

Malaysian Family Physician, 2023
Metformin-induced sexual dysfunction is rare in patients with diabetes mellitus. Herein, we present the case of a 57-year-old man newly diagnosed with type 2 diabetes mellitus who developed erectile dysfunction following treatment with metformin 500 mg ...
Min Huang Ngu, Rosnani Zakaria, Maryam Mohd Zulkifli, Rahiza Bt Ab Rahman   +3 more
doaj   +1 more source

Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan

BMJ Open Diabetes Research & Care, 2020
Objective To assess the prevalence of vitamin B12 deficiency in people with type 2 diabetes mellitus (T2DM) on metformin and without metformin.Methodology Between May 2018 and January 2019, this prospective multicenter observational study recruited ...
Asher Fawwad, Nazish Waris, Bilal Tahir, Sobia Sabir Ali, Qazi Masroor, Salma Tanveer, Jamal Zafar, Zahid Miyan, Khalid Usman, Khursheed Ahmed, Riaz A Malik   +10 more
doaj   +1 more source

Metformin ameliorates the severity of experimental Alport syndrome

Scientific Reports, 2021
Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis.
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai   +17 more
doaj   +1 more source

Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study

Clinical and Translational Science, 2021
The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously ...
Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen   +8 more
doaj   +1 more source