Results 51 to 60 of about 320,201 (374)
Metformin treatment for diabetes mellitus correlates with progression and survival in colorectal carcinoma [PDF]
, 2020 BACKGROUND: Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multi-disciplinary project was to evaluate a possible association of diabetes mellitus and other comorbidities and their treatment with progression of ...
Brown, Robert E. +10 more
core +1 more source
Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in the Li-Fraumeni Syndrome model, Trp53+/- mice [PDF]
, 2014 BACKGROUND: While genetic testing for familial cancer has excelled, the prevention options for those carrying high risk alleles have not. Altered bioenergetics is now acknowledged as a hallmark of cancer, and several very safe drugs are available ...
Blackburn, Anneke +4 more
core +1 more source
Metformin from mother to unborn child – Are there unwarranted effects?
EBioMedicine, 2018 For more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus.
Linh Nguyen +2 more
doaj +1 more source
Drugs in R & D, 2005 Metformin extended release [Glumetza, metformin hydrochloride, metformin gastric retention, metformin GR] is a proprietary once-a-day formulation of metformin hydrochloride under development with Depomed for the treatment of diabetes mellitus. In May 2002, Depomed licensed manufacturing and marketing rights for its proprietary formulation of metformin ...
openaire +4 more sources
Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]
, 2015 Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C +7 more
core +1 more source
Diabetes Care, 2021 OBJECTIVE To determine the longer-term effects of metformin treatment and behavioral weight loss on gut microbiota and short-chain fatty acids (SCFAs). RESEARCH DESIGN AND METHODS We conducted a 3-parallel-arm, randomized trial.
N. Mueller +7 more
semanticscholar +1 more source
Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. [PDF]
PLoS ONE, 2015 Recently, the pleiotropic benefits of incretin-based therapy have been reported. We have previously reported that Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, attenuates prostate cancer growth.
Yoko Tsutsumi +9 more
doaj +1 more source
The Oncologist, 2009 The article examines the effects of metformin in both diabetes and cancer.
Curtis R, Chong, Bruce A, Chabner
openaire +2 more sources
Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia [PDF]
, 2011 OBJECTIVE: Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral ...
Bodmer, Michael +4 more
core +2 more sources
NeuroSci, 2022 In our previous study, metformin was able to promote nerve regeneration after sciatic nerve crushing in rats under diabetic conditions. However, a crush injury also has a strong ability to spontaneously recover.
Junxiong Ma +4 more
doaj +1 more source