Results 71 to 80 of about 297,887 (387)
Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in the Li-Fraumeni Syndrome model, Trp53+/- mice [PDF]
, 2014 BACKGROUND: While genetic testing for familial cancer has excelled, the prevention options for those carrying high risk alleles have not. Altered bioenergetics is now acknowledged as a hallmark of cancer, and several very safe drugs are available ...
Blackburn, Anneke +4 more
core +1 more source
Should metformin remain the first-line therapy for treatment of type 2 diabetes?
Therapeutic Advances in Endocrinology and Metabolism, 2021 Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications.
Chelsea Baker +5 more
semanticscholar +1 more source
Intracerebroventricular Injection of Metformin Induces Anorexia in Rats [PDF]
Diabetes & Metabolism Journal, 2012 BackgroundMetformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known.MethodsTo evaluate whether metformin ...
Chang Koo Lee +5 more
doaj +1 more source
Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]
, 2015 Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C +7 more
core +1 more source
Metformin reverses established lung fibrosis in a bleomycin model
Nature Network Boston, 2018 Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism regulates tissue repair and remodelling responses to injury2–4. AMPK is a critical sensor of
S. Rangarajan +13 more
semanticscholar +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2021 Thanida Tangjarusritaratorn,1 Watip Tangjittipokin,1,2 Tada Kunavisarut3 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence in Diabetes and Obesity, Faculty of ...
Tangjarusritaratorn T +2 more
doaj
Frontiers in Endocrinology, 2022 Background and aimsStudies have demonstrated that the short-term use of metformin benefits liver function among patients with type 2 diabetes mellitus (T2DM).
Kuang-Hua Huang +9 more
doaj +1 more source
Metformin treatment for diabetes mellitus correlates with progression and survival in colorectal carcinoma [PDF]
, 2020 BACKGROUND: Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multi-disciplinary project was to evaluate a possible association of diabetes mellitus and other comorbidities and their treatment with progression of ...
Brown, Robert E. +10 more
core +1 more source
Statin use and survival in resectable pancreatic cancer: confounders and mechanisms. [PDF]
, 2016 A first point regards the possible activity of drugs other than statins, such as aspirin or metformin, against pancreatic cancer. As many patients use a combination of these drugs, one might speculate that the association between simvastatin and overall ...
Archibugi, L +2 more
core +1 more source
Metformin in Reproductive Biology [PDF]
Frontiers in Endocrinology, 2018 Initially produced in Europe in 1958, metformin is still one of the most widely prescribed drugs to treat type II diabetes and other comorbidities associated with insulin resistance. Metformin has been shown to improve fertility outcomes in females with insulin resistance associated with polycystic ovary syndrome (PCOS) and in obese males with reduced ...
Melanie Faure +8 more
openaire +8 more sources