Results 81 to 90 of about 302,269 (383)
Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases
Advanced Healthcare Materials, EarlyView.This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun +9 more
wiley +1 more source
Journal of Medical Case Reports, 2019 Background Metformin has been widely used as a first-line agent to treat type 2 diabetes mellitus. Lactic acidosis is a rare but serious adverse effect in patients treated with metformin.
Hiroki Kinoshita +4 more
doaj +1 more source
Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. [PDF]
PLoS ONE, 2012 Metformin inhibits ATP production in mitochondria and this may be involved in the anti-hyperglycemic effects of the drug. Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase that regulates the function of the electron transport chain and maintains ...
Marcin Buler +3 more
doaj +1 more source
Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery
Advanced Healthcare Materials, EarlyView.This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo +3 more
wiley +1 more source
Frontiers in Pharmacology, 2022 Objectives: To investigate the risk of varicocele, erectile dysfunction (ED), infertility, prostatitis, benign prostate hyperplasia (BPH) and prostate cancer associated with metformin use.Materials and methods: A total of 261,838 males, mean age 52.39 ...
Chin-Hsiao Tseng +2 more
doaj +1 more source
Designing the Next Generation of Biomaterials through Nanoengineering
Advanced Materials, EarlyView.Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr. +3 more
wiley +1 more source
Metformin alleviates breast cancer through targeting high‐mobility group AT‐hook 2
Thoracic Cancer, 2020 Background As a classic oral drug used in diabetic patients, metformin has exhibited an anticancer role in many types of cancers in recent years. Here, we aimed to investigate the role of metformin in the growth of breast cancer and its novel targets ...
Yang Li, Dan Wang, Hui Ren, Wei Feng
doaj +1 more source
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin
BMC Cancer, 2021 Background Although the major anticancer effect of metformin involves AMPK-dependent or AMPK-independent mTORC1 inhibition, the mechanisms of action are still not fully understood.
Se-Kyeong Jang +8 more
doaj +1 more source
Gestational diabetes mellitus- right person, right treatment, right time? [PDF]
, 2017 Background: Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases.
Lindsay, Robert S. +2 more
core +1 more source
Metformin and blood cancers [PDF]
Clinics, 2018 Type 2 diabetes mellitus and cancer are correlated with changes in insulin signaling, a pathway that is frequently upregulated in neoplastic tissue but impaired in tissues that are classically targeted by insulin in type 2 diabetes mellitus. Many antidiabetes treatments, particularly metformin, enhance insulin signaling, but this pathway can be ...
Cunha Júnior, Ademar Dantas +2 more
openaire +5 more sources