Results 81 to 90 of about 320,201 (374)

Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway

Aging, 2020
Ischemia/reperfusion (I/R) injury is a life-threatening vascular emergency following myocardial infarction. Our previous study showed cardioprotective effects of metformin against myocardial I/R injury.
Jing Zhang, Lelin Huang, Xing Shi, Liu Yang, Fuzhou Hua, Jianyong Ma, Wengen Zhu, Xiao Liu, Rui Xuan, Yunfeng Shen, Jianping Liu, Xiaoyang Lai, Peng Yu   +12 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Metformin as a Therapeutic Target in Endometrial Cancers. [PDF]

, 2018
Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of ...
Johnson, Jennifer, Kim, Christine H., Lee, Teresa, Martinez-Outshoorn, Ubaldo E., Richard, Scott D., Rosenblum, Norman G., Schilder, Russell J.   +6 more
core   +2 more sources

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

Annals of the Rheumatic Diseases, 2020
Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression. Methods Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and AMP-activated protein kinase
Jun Li, Bin Zhang, Weixiao Liu, Ke Lu, H. Pan, Tingyu Wang, C. Oh, Dan Yi, Jian Huang, Lan Zhao, G. Ning, Cong Xing, G. Xiao, R. Liu-Bryan, S. Feng, Di Chen   +15 more
semanticscholar   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report

Journal of Medical Case Reports, 2019
Background Metformin has been widely used as a first-line agent to treat type 2 diabetes mellitus. Lactic acidosis is a rare but serious adverse effect in patients treated with metformin.
Hiroki Kinoshita, Machi Yanai, Koichi Ariyoshi, Motozumi Ando, Ryo Tamura   +4 more
doaj   +1 more source

Gestational diabetes mellitus- right person, right treatment, right time? [PDF]

, 2017
Background: Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases.
Lindsay, Robert S., Mackin, Sharon T., Nelson, Scott M.   +2 more
core   +1 more source

Should metformin remain the first-line therapy for treatment of type 2 diabetes?

Therapeutic Advances in Endocrinology and Metabolism, 2021
Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications.
Chelsea Baker, Cimmaron Retzik-Stahr, Vatsal Singh, R. Plomondon, Victoria Anderson, Neda Rasouli   +5 more
semanticscholar   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS : a systematic review [PDF]

, 2014
Peer reviewedPublisher ...
Colleran, Rebecca, Gemmel, Ailsa, Gill, Sabraj, O’Brian, Helen, Poobalan, Amudha, Zanuri, Nurhazwani Bt   +5 more
core   +2 more sources