Results 11 to 20 of about 6,618 (171)

The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride—In Vitro and In Vivo Evaluation

Molecules, 2017
Sodium alginate is a polymer with unique ability to gel with different cross-linking agents in result of ionic and electrostatic interactions. Chitosan cross-linked alginate provides improvement of swelling and mucoadhesive properties and might be used ...
Marta Szekalska, Katarzyna Sosnowska, A Zakrzeska   +2 more
exaly   +3 more sources

Development and validation of a new spectrophotometric method for simultaneous determination of sitagliptin and metformin hydrochloride in tablet pharmaceutical dosage forms using chemometrics technique in comparison with HPLC

Eclética Química, 2023
A new, quick, easy, affordable and eco-friendly simultaneous spectrophotometric method for determining a combined sitagliptin and metformin hydrochloride in pharmaceutical formulations was developed and validated using two chemometrics technique.
Maher Ali Almaqtari, Najat Ahmed Al-Odaini, Fares Abdullah Alarbagi, Hussein Al-Maydama   +3 more
doaj   +1 more source

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

Frontiers in Pharmacology, 2022
Epidemiologic data reveal that diabetes patients taking metformin exhibit lower incidence of stroke and better functional outcomes during post-stroke neurologic recovery.
Gufang Zhang, Shuangshuang Chen, Jia Jia, Chun Liu, Weipeng Wang, Weipeng Wang, Hongjian Zhang, Hongjian Zhang, Xuechu Zhen   +8 more
doaj   +1 more source

Application of Fourier Transform Infrared Spectrophotometry Method for Analysis of Metformin Hydrochloride in Marketed Tablet Dosage Form

Jurnal Kimia Valensi, 2021
The first line drug given for monotherapy for diabetes mellitus type 2 is metformin hydrochloride, which is a biguanide antihyperglycemic drug. The aim of this research was to develop, validate, and apply the Fourier Transform Infrared spectrophotometry ...
Nerdy Nerdy, Linda Margata, Dian Ika Perbina Meliala, Bunga Mari Sembiring, Selamat Ginting, Effendy De Lux Putra, Atika Mulyati, Tedy Kurniawan Bakri   +7 more
doaj   +1 more source

Preparation of metformin hydrochloride loaded pH-sensitive hydrogel microspheres

Journal of Hebei University of Science and Technology, 2021
In order to avoid the irritation of metformin hydrochloride to the stomach and realize its release in the intestine, with metformin hydrochloride as the main drug and chitosan/sodium alginate as the composite support, the optimal formulation and ...
Yinghua XIE, Zhaoxia LIU, Meimei ZHANG, Dongmei ZHANG   +3 more
doaj   +1 more source

Determination of glibenclamide, metformin hydrochloride and rosiglitazone maleate by reversed phase liquid chromatographic technique in tablet dosage form [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2014
A simple, precise and accurate high performance liquid chromatography (HPLC) method was developed for the simultaneous estimation of metformin hydrochloride, rosiglitazone maleate, glibenclamide present in multicomponent dosage forms ...
Havele Shweta S., Dhaneshwar Sunil R.
doaj   +1 more source

Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride [PDF]

Journal of Pharmaceutics, 2014
In the treatment of type 2 diabetes mellitus a continuous therapy is required which is a more complex one. As in these patients there may be a defect in both insulin secretion and insulin action exists. Hence, the treatment depends on the pathophysiology and the disease state.
Chowdary, Y. Ankamma, Raparla, Ramakrishna, Madhuri, Muramshetty   +2 more
openaire   +2 more sources

Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride [PDF]

ISRN Pharmaceutics, 2012
Purpose. The objective of the proposed work is to evaluate the efficacy of Pectins to qualify them as polymers for designing an oral microsphere for the delivery of selected oral antidiabetic drug-like metformin hydrochloride. Methods. Different Microspheres formulations were prepared by the water in oil (w\o) emulsion solvent evaporation technique and
Banerjee, Pritam, Deb, Jyotirmoy, Roy, Amitava, Ghosh, Amitava, Chakraborty, Prithviraj   +4 more
openaire   +2 more sources

Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode

Acta Chimica Slovenica, 2015
The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry.
Ali Kamal Attia, Waheed M Salem, Mona A Mohamed   +2 more
doaj   +1 more source

Comparison of Clinical Efficacy and Safety of Metformin Sustained-Release Tablet (II) (Dulening) and Metformin Tablet (Glucophage) in Treatment of Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2021
ObjectivesThis study investigated the clinical efficacy and safety of metformin hydrochloride sustained-release (SR) tablet (II) produced by Dulening and the original metformin hydrochloride tablet produced by Glucophage in the treatment of type 2 ...
Li-xin Guo, Guo-en Liu, Li Chen, Hai-fang Wang, Jian Guo, Xian-ling Zheng, Bin-hong Duan, De-zhong Wang, Wei Zhu, Kun Wang, Wan-shou Tan, Qiu Chen, Quan-zhong Li, Jing Yang, Qiu Zhang, Pei-feng Xie, Min-xiang Lei   +16 more
doaj   +1 more source