Results 11 to 20 of about 13,870 (205)

Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride. [PDF]

J Control Release, 2018
We investigated, for the first time, the potential for a hydrogel-forming microneedle (MN) patch to deliver the high-dose drug metformin HCl transdermally in a sustained manner. This may minimize some gastrointestinal side effects and small intestine absorption variations associated with oral delivery.
Migdadi EM, Courtenay AJ, Tekko IA, McCrudden MTC, Kearney MC, McAlister E, McCarthy HO, Donnelly RF.   +7 more
europepmc   +7 more sources

In vitro comparative quality evaluation of different brands of metformin hydrochloride tablets available in Mekelle City, Tigray Regional State, Ethiopia [PDF]

BMC Pharmacology and Toxicology
Background Administration of poor-quality medications can result in various effects that jeopardize the drugs’ safety and effectiveness. Due to a lack of adequate post-market surveillance studies, making decisions regarding the quality of medicines ...
Brhane Gebrehiwot Welegebrial, Zenawi Gezae, Samrawit Kidanemariam Gebrekidan, Gebru Gebremeskel Gebrerufael, Haylay Araya Gebregzabiher, Abrahaley Mulu Kidane, Gebretekle Gebremichael Hailesilase   +6 more
doaj   +2 more sources

Safety of anagliptin/metformin combination tablets evaluated by non‐inferiority between pre‐ and post‐serum lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment (AMELIO STUDY)

Journal of Diabetes Investigation
Aims/Introduction To investigate the safety of anagliptin/metformin combination tablets by evaluation of lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment. Materials and Methods The participants of type 2 diabetes
Hiroshi Kajio, Ryotaro Bouchi, Mitsuhisa Komatsu, Masanori Yamazaki, Daisuke Takarabe, Masahide Okamoto, Takahisa Tanaka, Toru Kitazawa, Hisayuki Katsuyama, Yasumichi Mori, Mitsuhiko Noda   +10 more
doaj   +2 more sources

The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride—In Vitro and In Vivo Evaluation

Molecules, 2017
Sodium alginate is a polymer with unique ability to gel with different cross-linking agents in result of ionic and electrostatic interactions. Chitosan cross-linked alginate provides improvement of swelling and mucoadhesive properties and might be used ...
Marta Szekalska, Katarzyna Sosnowska, Agnieszka Zakrzeska, Irena Kasacka, Alicja Lewandowska, Katarzyna Winnicka   +5 more
doaj   +3 more sources

Evaluation of Seven Different Brands of Metformin Hydrochloride Tablets Available in the Market in Gondar City, Ethiopia [PDF]

Drug, Healthcare and Patient Safety
Adane Flatie Alemu,1 Addisu Afrassa Tegegne,2 Nurahmed Seid Getaw1 1Pharmaceutical Analysis, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Pharmaceutical Quality Assurance and Regulatory Affairs ...
Flatie Alemu A, Tegegne AA, Getaw NS
doaj   +2 more sources

Multifractal Analysis and Experimental Evaluation of MCM-48 Mesoporous Silica as a Drug Delivery System for Metformin Hydrochloride [PDF]

Biomedicines
Background: This study explored the potential of MCM-48 mesoporous silica matrices as a drug delivery system for metformin hydrochloride, aimed at improving the therapeutic management of type 2 diabetes mellitus. The objectives included the synthesis and
Mousa Sha’at, Maria Ignat, Liviu Sacarescu, Adrian Florin Spac, Alexandra Barsan (Bujor), Vlad Ghizdovat, Emanuel Nazaretian, Catalin Dumitras, Maricel Agop, Cristina Marcela Rusu, Lacramioara Ochiuz   +10 more
doaj   +2 more sources

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
AN Macintyre, AS Green, Benoit Viollet, C Grimaldi, David K. Finlay, DG Hardie, Doreen A. Cantrell, EL Pearce, EL Pearce, GD Holman, I Ben Sahra, JD Powell, K Araki, LV Sinclair, M Foretz, M Zarrouk, Marc Foretz, Marouan Zarrouk, MR Owen, N Nath, N Zhang, NJ MacIver, NJ MacIver, P Tamas, Ping Song, R Wang, R Wang, RA Miller, RD Michalek, S He   +29 more
core   +19 more sources

Development and validation of a new spectrophotometric method for simultaneous determination of sitagliptin and metformin hydrochloride in tablet pharmaceutical dosage forms using chemometrics technique in comparison with HPLC

Eclética Química, 2023
A new, quick, easy, affordable and eco-friendly simultaneous spectrophotometric method for determining a combined sitagliptin and metformin hydrochloride in pharmaceutical formulations was developed and validated using two chemometrics technique.
Maher Ali Almaqtari, Najat Ahmed Al-Odaini, Fares Abdullah Alarbagi, Hussein Al-Maydama   +3 more
doaj   +1 more source

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

Frontiers in Pharmacology, 2022
Epidemiologic data reveal that diabetes patients taking metformin exhibit lower incidence of stroke and better functional outcomes during post-stroke neurologic recovery.
Gufang Zhang, Shuangshuang Chen, Jia Jia, Chun Liu, Weipeng Wang, Weipeng Wang, Hongjian Zhang, Hongjian Zhang, Xuechu Zhen   +8 more
doaj   +1 more source

Application of Fourier Transform Infrared Spectrophotometry Method for Analysis of Metformin Hydrochloride in Marketed Tablet Dosage Form

Jurnal Kimia Valensi, 2021
The first line drug given for monotherapy for diabetes mellitus type 2 is metformin hydrochloride, which is a biguanide antihyperglycemic drug. The aim of this research was to develop, validate, and apply the Fourier Transform Infrared spectrophotometry ...
Nerdy Nerdy, Linda Margata, Dian Ika Perbina Meliala, Bunga Mari Sembiring, Selamat Ginting, Effendy De Lux Putra, Atika Mulyati, Tedy Kurniawan Bakri   +7 more
doaj   +1 more source