Results 21 to 30 of about 13,870 (205)

Preparation of metformin hydrochloride loaded pH-sensitive hydrogel microspheres

Journal of Hebei University of Science and Technology, 2021
In order to avoid the irritation of metformin hydrochloride to the stomach and realize its release in the intestine, with metformin hydrochloride as the main drug and chitosan/sodium alginate as the composite support, the optimal formulation and ...
Yinghua XIE, Zhaoxia LIU, Meimei ZHANG, Dongmei ZHANG   +3 more
doaj   +1 more source

Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [PDF]

, 2018
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN),
Boza-Serrano, Antonio,, de Pablos, Rocío M.,, Deierborg, Tomas,, Espinosa-Oliva, Ana M.,, García-Domínguez, Irene,, Herrera, Antonio J.,, Ismaiel, Afrah Abdul,, Lund University., Lund University., Machado, Alberto,, Tayara, Khadija,, Venero, José L.,   +11 more
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Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode

Acta Chimica Slovenica, 2015
The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry.
Ali Kamal Attia, Waheed M Salem, Mona A Mohamed   +2 more
doaj   +1 more source

Comparison of Clinical Efficacy and Safety of Metformin Sustained-Release Tablet (II) (Dulening) and Metformin Tablet (Glucophage) in Treatment of Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2021
ObjectivesThis study investigated the clinical efficacy and safety of metformin hydrochloride sustained-release (SR) tablet (II) produced by Dulening and the original metformin hydrochloride tablet produced by Glucophage in the treatment of type 2 ...
Li-xin Guo, Guo-en Liu, Li Chen, Hai-fang Wang, Jian Guo, Xian-ling Zheng, Bin-hong Duan, De-zhong Wang, Wei Zhu, Kun Wang, Wan-shou Tan, Qiu Chen, Quan-zhong Li, Jing Yang, Qiu Zhang, Pei-feng Xie, Min-xiang Lei   +16 more
doaj   +1 more source

A new perspective on metformin therapy in type 1 diabetes [PDF]

, 2017
Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G., Livingstone, Rachel, Petrie, John R.   +2 more
core   +1 more source

A volumetric and viscometric study of 4-aminobutyric acid in aqueous solutions of metformin hydrochloride at 308.15, 313.15 and 318.15 K [PDF]

, 2011
Density (r) and viscosity (h) measurements were performed for4-aminobutyric acid in 0.05, 0.10 and 0.15 M aqueous metformin hydrochloride at 308.15, 313.15 and 318.15 K.
KRISHA RAJAGOPAL, S. S. JAYABALAKRISHNAN
core   +1 more source

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua, Chou, Caroline Ei Ne, Dawson, David W, Eibl, Guido, French, Samuel, Hao, Fang, Hines, O Joe, Moro, Aune, Rozengurt, Enrique, Schmidt, Andrea I, Sinnett-Smith, James   +10 more
core   +2 more sources

Effect and Safety of Pioglitazone-Metformin Tablets in the Treatment of Newly Diagnosed Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease in Shaanxi Province: A Randomized, Double-Blinded, Double-Simulated Multicenter Study

Journal of Diabetes Research, 2023
Objective. The aim of study was to evaluate the effect and safety of pioglitazone-metformin combined treatment in the newly diagnosed type 2 diabetes patients with nonalcoholic fatty liver disease. Methods.
Fu Jianfang, Xiao Wanxia, Gao Xiling, Xu Jing, Yang Wenjuan, Liu Jianrong, He Qingzhen, Ma Kaiyan, Lian Jingxuan, Chen Taixiong, Xu Qian, Li Mengying, Ming Jie, Ji Qiuhe   +13 more
doaj   +1 more source

A survey of Top 200 Drugs—Inconsistent Practice of Drug Strength Expression for Drugs Containing Salt Forms [PDF]

, 2012
Many ionizable drugs are developed and marketed as salt forms. However, there are no clear US regulatory guidelines on drug strength labeling for salts. The strengths of some drugs are expressed as salts and some as free acids/bases.
Prohotsky, Daniel, Zhao, Fang
core   +2 more sources

Bis{[amino(iminiumyl)methyl]urea} tetrakis{2-[(dimethylamino)(iminiumyl)methyl]guanidine} di-μ6-oxido-tetra-μ3-oxido-tetradeca-μ2-oxido-octaoxidodecavanadium(V) tetrahydrate

IUCrData, 2022
The title compound, (C4H12N5)4(C2H7N4O)2[V10O28]·4H2O, is a by-product obtained by reacting ammonium metavanadate(V), metformin hydrochloride and acetic acid in the presence of sodium hypochlorite, at pH = 5.
Aarón Pérez-Benítez, Jorge Luis Ariza-Ramírez, Monserrat Fortis-Valera, Rosa Elena Arroyo-Carmona, María Isabel Martínez de la Luz, Diego Ramírez-Contreras, Sylvain Bernès   +6 more
doaj   +1 more source