Results 41 to 50 of about 6,618 (171)

Estimation of Pioglitazone Hydrochloride and Metformin Hydrochloride in Tablets by Derivative Spectrophotometry and Liquid Chromatographic Methods [PDF]

Journal of AOAC INTERNATIONAL, 2005
Abstract Two simple and accurate methods of analysis to determine pioglitazone hydrochloride (PIO) and metformin hydrochloride (MET) in combined dosage forms were developed using second-derivative spectrophotometry and reversed-phase liquid chromatography (LC).
Madhira B, Shankar, Vaibhav D, Modi, Dimal A, Shah, Kashyap K, Bhatt, Rajendra S, Mehta, Madhira, Geetha, Binita J, Patel   +6 more
openaire   +2 more sources

Platelet‐Rich Fibrins as Local Drug‐Delivery Carriers

Journal of Periodontal Research, EarlyView.
Autologous platelet concentrates (APCs), particularly platelet‐rich fibrin (PRF), act as biologically active fibrin scaffolds, capable of entrapping and gradually releasing therapeutic agents in oral and periodontal therapy. The incorporation of bioactive compounds, such as antibiotics, antifungals, vitamins, antidiabetic drugs, and exosomes, enhances ...
Karim M. Fawzy El‐Sayed, Christof E. Dörfer   +1 more
wiley   +1 more source

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Quantitative Determination and Validation of Metformin Hydrochloride in Pharmaceutical Using Quantitative Nuclear Magnetic Resonance Spectroscopy

E-Journal of Chemistry, 2011
Rapid, specific and accurate proton nuclear magnetic resonance spectroscopy (1H NMR) method was developed to determine metformin hydrochloride antidiabetic drug in pharmaceutical tablet formulation.
H. H. Gadape, K. S. Parikh
doaj   +1 more source

Antioxidative effect of metformin on valproic acid induced hepatoxicity in male rats

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Metformin is 1,1-dimethylbiguanide hydrochloride, is the first-line therapy for type 2 diabetes. Additionally, several studies focused on the role of metformin in antioxidant activities for the treatment of hepatic disorders. The experimentally    
Intesar Tarik Numan, Nadia Hameed Mohamed, Zainab Khalid Ali   +2 more
doaj   +1 more source

Formulation Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride [PDF]

Journal of Young Pharmacists, 2010
The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR)
Patil, SA, Kuchekar, BS, Chabukswar, AR, Jagdale, SC   +3 more
openaire   +2 more sources

Cordyceps militaris Ethanol Extract Alleviates Hyperglycemia in Type 2 Diabetic Mice in Association With Gut Microbiota Modification

eFood, Volume 7, Issue 4, August 2026.
Cordyceps militaris ethanol extract (CME) shows potential for ameliorating glucose and lipid metabolism in T2DM mice. The improvements are correlated with the regulation of gut microbiota and increased short‐chain fatty acid levels, offering a novel perspective for future diabetes interventions.
Huanhuan Wen, Wenke Hu, Xinru Xu, Na Wu, Huangcong Ding, Haonan Wang, Xiaoyu Gao, Ligen Chen, Chao Zhao, Rong Shao, Wei Xu   +10 more
wiley   +1 more source

Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6207-6216, July 2026.
ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay, Ambanna Gowda, Manish Kumar Singh, A. Gopal Rao, Ramesh Duraisamy, Dinesh Gangwani, Jitendra Shukla, Vikas Agarwal, Sandesh Sahebarao Patil, Ambrish C., Satish Babu K. N., Arvind Palawat, Sandip Krishnrao Gofne, Abhay Kumar Sahoo, Pradeep Kumar Rai, Raisa Shaikh, Shruti Saha, Dipak Patil, Pravin Ghadge, Piyush Patel, Lalit Lakhwani, Suyog Mehta, Sadhna Joglekar   +22 more
wiley   +1 more source

Redirecting Alzheimer's disease therapeutics: Multitarget drugs and complementary non‐pharmacological strategies

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug‐development pipelines highlights the limited clinical impact of single‐target therapies and has increased interest in multi‐target approaches acting on shared biological hubs.
Humberto Martínez‐Orozco, Jesús Andrade‐Guerrero, Nelly Jovana Pastén‐Castrejón, Chryslaine Rodríguez‐Tanty, Sofía Y Diaz‐Miranda   +4 more
wiley   +1 more source

Box–Behnken design assisted HPTLC method for quantification of teneligliptin hydrobromide hydrate, metformin hydrochloride and pioglitazone hydrochloride in pharmaceutical dosage form

Discover Chemistry
A Design of expert approach was used to develop and validate a high-performance thin layer chromatography method for simultaneously determining Teneligliptin hydrobromide hydrate, Metformin hydrochloride, and Pioglitazone hydrochloride in tablets.
Patel Kalpana, Babariya Raj, Shah Hitaxi, Tandel Devang, Patel Subhashchandra, Gandhi Tejal   +5 more
doaj   +1 more source