Results 51 to 60 of about 6,634 (171)

Cordyceps militaris Ethanol Extract Alleviates Hyperglycemia in Type 2 Diabetic Mice in Association With Gut Microbiota Modification

eFood, Volume 7, Issue 4, August 2026.
Cordyceps militaris ethanol extract (CME) shows potential for ameliorating glucose and lipid metabolism in T2DM mice. The improvements are correlated with the regulation of gut microbiota and increased short‐chain fatty acid levels, offering a novel perspective for future diabetes interventions.
Huanhuan Wen, Wenke Hu, Xinru Xu, Na Wu, Huangcong Ding, Haonan Wang, Xiaoyu Gao, Ligen Chen, Chao Zhao, Rong Shao, Wei Xu   +10 more
wiley   +1 more source

Simultaneous Estimation of Metformin Hydrochloride, Pioglitazone Hydrochloride, and Glimepiride by RP-HPLC in Tablet Formulation [PDF]

Journal of Chromatographic Science, 2008
A simple, precise, rapid, and reproducible reversed-phase high-performance liquid chromatography method is developed for the simultaneous estimation of metformin hydrochloride (MET), pioglitazone hydrochloride (PIO), and glimepiride (GLP) present in multicomponent dosage forms. Chromatography is carried out isocratically at 25 degrees C +/- 0.5 degrees
Deepti, Jain, Surendra, Jain, Deepak, Jain, Maulik, Amin   +3 more
openaire   +2 more sources

HPLC and HPTLC methods for simultaneous quantification of Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol with comparative evaluation by greenness and whiteness assessment tools

Green Analytical Chemistry
The combination of Vildagliptin, Dapagliflozin propanediol monohydrate and Metformin hydrochloride has been approved by Central Drug Standard Control Organization in March 2023 for conducting Phase III trial for treatment of diabetes mellitus.
Krinal Barot, Vedika Thakkar, Devang Tandel, Gopi Patel, Rajesh Parmar, Kalpana Patel   +5 more
doaj   +1 more source

Study on the Effects and Mechanisms of Sea Buckthorn Fruit Pulp in Improving Polycystic Ovary Syndrome

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Sea buckthorn pulp improves metabolic and reproductive dysfunction in a letrozole‐induced PCOS mouse model and is associated with modulation of the PI3K/AKT/mTOR signaling pathway. ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder characterized by ovarian dysfunction, hyperandrogenism, and insulin resistance.
Han Xiaoya, Yang Yuanyuan, Peng Qingjie, Chen Xiaojiang, Ma Cunling, Li Na, Tian Xiaofan, Wu Xin, Liu Hetao, He Rui   +9 more
wiley   +1 more source

Estimation of Pioglitazone Hydrochloride and Metformin Hydrochloride in Tablets by Derivative Spectrophotometry and Liquid Chromatographic Methods [PDF]

Journal of AOAC INTERNATIONAL, 2005
Abstract Two simple and accurate methods of analysis to determine pioglitazone hydrochloride (PIO) and metformin hydrochloride (MET) in combined dosage forms were developed using second-derivative spectrophotometry and reversed-phase liquid chromatography (LC).
Madhira B, Shankar, Vaibhav D, Modi, Dimal A, Shah, Kashyap K, Bhatt, Rajendra S, Mehta, Madhira, Geetha, Binita J, Patel   +6 more
openaire   +2 more sources

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Sarcopenia is a major contributor to frailty and mortality in ageing and obesity and is tightly linked to metabolic dysfunction. Imeglimin is a first‐in‐class oral hypoglycaemic agent targeting mitochondrial function; however, despite the central role of mitochondria in skeletal muscle homeostasis, its effects on skeletal muscle ...
Yangli Ye, Diandian Qian, Ikumi Nomura, Naoki Kobayashi, Yukiko Shimizu, Tadashi Okamura, Motoharu Awazawa, Kohjiro Ueki   +7 more
wiley   +1 more source

Formulation Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride [PDF]

Journal of Young Pharmacists, 2010
The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR)
Patil, SA, Kuchekar, BS, Chabukswar, AR, Jagdale, SC   +3 more
openaire   +2 more sources

Oleanolic Acid Ameliorates Hepatic Lipid Metabolism and Autophagy in Type 2 Diabetic Mice via the STAT3 Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This study demonstrates that oleanolic acid (OA) may ameliorate type 2 diabetes mellitus (T2DM) by modulating hepatic lipid metabolism and autophagy in a manner concomitant with STAT3 phosphorylation. Specifically, OA downregulates fatty acid synthesis/uptake‐related proteins (SREBP‐1, ACC, CD36), upregulates fatty acid β‐oxidation‐related protein ...
Zirui Ji, Yuanfeng Huang, Xiangjin Pu, Jinqing Feng, Yiwen Liao, Wanfen Lin, Qing Zhu, Weixuan Wang   +7 more
wiley   +1 more source

Repurposing Metformin to Promote Fracture Callus Maturation via AMPK‐Driven Metabolic Activation

Journal of Orthopaedic Research, Volume 44, Issue 7, July 2026.
ABSTRACT Femoral shaft fractures cause prolonged disability, and therapies that accelerate bone repair remain limited. Repurposing clinically approved drugs that target biological bottlenecks in healing is a promising strategy. This study investigated whether systemic metformin administration, an anti‐diabetic medication with known metabolic regulatory
Vasyl Pastukh, Jianying Zhang, Peter G. Alexander, Satyaj Bhargava, Arshia Shams, Celina Zhao, MaCalus V. Hogan, James H‐C. Wang   +7 more
wiley   +1 more source