Results 51 to 60 of about 13,870 (205)

Impurity profiling method development and validation of metformin hydrochloride and teneligliptin hydrobromide hydrate in their combination tablet dosage form by using RP-HPLC with UV/PDA detector

Future Journal of Pharmaceutical Sciences, 2021
Background An accurate, precise and robust analytical method was developed for the impurity profiling in the metformin hydrochloride and teneligliptin hydrobromide hydrate tablet.
B. D. Musmade, M. L. Baraskar, V. N. Ghodke, S. G. Bhope, S. Padmanabhan, K. S. Lohar   +5 more
doaj   +1 more source

Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay, Ambanna Gowda, Manish Kumar Singh, A. Gopal Rao, Ramesh Duraisamy, Dinesh Gangwani, Jitendra Shukla, Vikas Agarwal, Sandesh Sahebarao Patil, Ambrish C., Satish Babu K. N., Arvind Palawat, Sandip Krishnrao Gofne, Abhay Kumar Sahoo, Pradeep Kumar Rai, Raisa Shaikh, Shruti Saha, Dipak Patil, Pravin Ghadge, Piyush Patel, Lalit Lakhwani, Suyog Mehta, Sadhna Joglekar   +22 more
wiley   +1 more source

Platelet‐Rich Fibrins as Local Drug‐Delivery Carriers

Journal of Periodontal Research, EarlyView.
Autologous platelet concentrates (APCs), particularly platelet‐rich fibrin (PRF), act as biologically active fibrin scaffolds, capable of entrapping and gradually releasing therapeutic agents in oral and periodontal therapy. The incorporation of bioactive compounds, such as antibiotics, antifungals, vitamins, antidiabetic drugs, and exosomes, enhances ...
Karim M. Fawzy El‐Sayed, Christof E. Dörfer   +1 more
wiley   +1 more source

Metformin – újabb adatok egy megbízható és hatékony „régi” vércukorcsökkentő készítményről [PDF]

, 2016
Absztrakt A metformin a 2-es típusú diabetes vércukorcsökkentő kezelésének alapgyógyszere: a hatályos kezelési irányelvek szerint ellenjavallat/intolerancia hiányában adását a betegség egész ...
Winkler, Gábor
core   +1 more source

Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride [PDF]

ISRN Pharmaceutics, 2012
Purpose. The objective of the proposed work is to evaluate the efficacy of Pectins to qualify them as polymers for designing an oral microsphere for the delivery of selected oral antidiabetic drug-like metformin hydrochloride. Methods. Different Microspheres formulations were prepared by the water in oil (w\o) emulsion solvent evaporation technique and
Banerjee, Pritam, Deb, Jyotirmoy, Roy, Amitava, Ghosh, Amitava, Chakraborty, Prithviraj   +4 more
openaire   +2 more sources

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Applying metabolomics to cardiometabolic intervention studies and trials: past experiences and a roadmap for the future [PDF]

, 2016
Metabolomics and lipidomics are emerging methods for detailed phenotyping of small molecules in samples. It is hoped that such data will: (i) enhance baseline prediction of patient response to pharmacotherapies (beneficial or adverse); (ii) reveal ...
Preiss, David, Rankin, Naomi J., Sattar, Naveed, Welsh, Paul   +3 more
core   +2 more sources

Comparative Bioavailability of Metformin Hydrochloride Oral Solution Versus Metformin Hydrochloride Tablets in Fasting Mexican Healthy Volunteers

Advances in Therapy, 2018
Metformin tablets may be challenging to swallow not only for those patients with dysphagia but also for children and the elderly. A metformin solution was developed for easier administration and flexible dose adjustment mantained with the same bioavailability of tablets.
Lourdes, Garza-Ocañas, Jorge, González-Canudas, Eduardo, Tamez-de la O, Christian, Badillo-Castañeda, Marco Vinicio, Gómez-Meza, Yulia, Romero-Antonio, Aarón, Molina-Pérez, Ana Gabriela, Amador-Hernández   +7 more
openaire   +2 more sources

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Quantitative Determination and Validation of Metformin Hydrochloride in Pharmaceutical Using Quantitative Nuclear Magnetic Resonance Spectroscopy

E-Journal of Chemistry, 2011
Rapid, specific and accurate proton nuclear magnetic resonance spectroscopy (1H NMR) method was developed to determine metformin hydrochloride antidiabetic drug in pharmaceutical tablet formulation.
H. H. Gadape, K. S. Parikh
doaj   +1 more source