Results 51 to 60 of about 6,618 (171)

Atom‐by‐Atom Multimetal CuMoP Deposition on Carbon Electrodes for Sensitive Antidiabetic Metformin Electrooxidation

Analytical Science Advances, Volume 7, Issue 1, June 2026.
An atom‐by‐atom ternary Cu–Mo–P nanocomposite is electrochemically co‐deposited onto screen‐printed carbon electrodes to create a highly active sensing interface for metformin detection. The porous mixed‐valence network enhances electroactive surface area and charge transfer, enabling sensitive and selective electrooxidation with a low detection limit.
Hong Wan, Mingfang Zhan, Chunyan Yin, Sima Akter, Sakil Mahmud   +4 more
wiley   +1 more source

A 32‐Year‐Old Man With an Cardiomyopathy

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Scleredema is a sclerosing dermatosis of unknown etiology, characterized by non‐punctate, weakly infiltrated skin thickening and swelling, which can lead to the development of cardiomyopathy. Scleredema‐associated cardiomyopathy is at present poorly understood.
Yuting Zou, Shan Li, Tong Chen, Yi Li
wiley   +1 more source

HPLC and HPTLC methods for simultaneous quantification of Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol with comparative evaluation by greenness and whiteness assessment tools

Green Analytical Chemistry
The combination of Vildagliptin, Dapagliflozin propanediol monohydrate and Metformin hydrochloride has been approved by Central Drug Standard Control Organization in March 2023 for conducting Phase III trial for treatment of diabetes mellitus.
Krinal Barot, Vedika Thakkar, Devang Tandel, Gopi Patel, Rajesh Parmar, Kalpana Patel   +5 more
doaj   +1 more source

Structural Characterization and Hypoglycemic Effects of a Purified Polysaccharide From Cinnamomum cassia

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
CCP1A, a polysaccharide purified from Cinnamomum cassia with a molecular weight of approximately 8.16 kDa and rich in glucose and galacturonic acid, exerts anti‐type 2 diabetes effects through a multi‐target synergistic mechanism. On one hand, it delays intestinal glucose absorption by inhibiting the activities of α‐amylase and α‐glucosidase in the ...
Liquan Zhou, Yimiao Zhou, Chen Ding, Lin Yang, Tianjin Ma, Xiao Liu, Zuowei Xiao   +6 more
wiley   +1 more source

Exploring the Nutraceutical Potential of Achillea millefolium L.: Phytochemical Composition, Biological Activities, and Industrial Applications

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Achillea millefolium Linn., commonly known as yarrow, is an extraordinary medicinal plant. A. millefolium has broad therapeutic potential due to its phytochemistry and essential oil composition. It possesses pharmacological properties, including antidiabetic, antioxidant, anti‐inflammatory, liver‐protective, antimicrobial, and gastroprotective effects,
Tooba Majeed, Muhammad Tauseef Sultan, Ahmad Mujtaba Noman, Hassan Raza, Hagar M. Mohamed, Nimra Anees, Muhammad Imran, Muzzamal Hussain, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Entessar Al Jbawi, Ehab M. Mostafa, Samy Selim, Ayman Salama, Mohamed A. Abdelgawad   +14 more
wiley   +1 more source

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Drug Delivery, 2015
Metformin hydrochloride is a biguanide derivative widely used for the treatment of type 2 diabetes, prescribed nearly to 120 million people worldwide. Metformin has a relatively low oral bioavailability (about 50-60%). Although the major effect of metformin is to decrease hepatic glucose output as an antihyperglycemic agent, its inhibitory effects on ...
Çetin, Meltem, Şahin, Selma
openaire   +3 more sources

A Robust and Universal LC–MS/MS Method for Determination of N‐Nitrosodimethylamine in Pharmaceuticals Using a C30 Column

Journal of Separation Science, Volume 49, Issue 6, June 2026.
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An, Unyong Kim, Sumin Seo, Jiyu Kim, Chohee Jeong, Woojin Jeong, Eunjin Ko, Juhyeon Kim, Hyun‐Deok Cho, Sang Beom Han   +9 more
wiley   +1 more source

Microplastic as a Vector of Metformin: Influence of Aging on Adsorption and Desorption Properties

Environmental Quality Management, Volume 35, Issue 4, Summer 2026.
ABSTRACT This study investigated how ultraviolet aging alters the physicochemical properties of polyethylene microplastics and affects the adsorption and desorption of metformin in water. Virgin polyethylene microspheres (PMP) were irradiated for 30 (MP30) and 120 (MP120) days to simulate environmental weathering. Aging caused evident surface cracking,
Luanna Gláucia Guimarães, Victor Hugo Souza Florentino Porto, Renata Medici Frayne Cuba, Francisco Javier Cuba Teran   +3 more
wiley   +1 more source

Investigation of Spexin Effects on Insulin‐Dependent Pathway Genes in High‐Glucose‐Induced Insulin‐Resistant C2C12 Myotubes

FASEB BioAdvances, Volume 8, Issue 6, June 2026.
This study investigated spexin in high‐glucose–induced insulin‐resistant C2C12 myotubes, focusing on its ability to modulate insulin‐signaling pathways and the glucose transporter GLUT4. These findings highlight spexin's potential role in improving peripheral insulin sensitivity by regulating key molecular targets involved in glucose homeostasis ...
Ann Sze Cheah, Ji Wei Tan, Faizul Jaafar, Wendy Wai Yeng Yeo   +3 more
wiley   +1 more source

Some conceptual aspects and practice of Mohr method in the determination metformin hydrochloride in pharmaceutical formulations

Semina: Ciências Exatas e Tecnológicas, 2013
In this paper conceptual aspects and practices of Mohr method in the determination of metformin hydrochloride in pharmaceutical formulations are described. This experiment is simple and might be a good alternative to be applied in an experimental subject
Willian Toito Suarez, Elen Romão Sartori, Orlando Fatibello-Filho   +2 more
doaj   +1 more source