Results 71 to 80 of about 13,870 (205)

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

HPLC and HPTLC methods for simultaneous quantification of Metformin hydrochloride, Vildagliptin and Dapagliflozin propanediol with comparative evaluation by greenness and whiteness assessment tools

Green Analytical Chemistry
The combination of Vildagliptin, Dapagliflozin propanediol monohydrate and Metformin hydrochloride has been approved by Central Drug Standard Control Organization in March 2023 for conducting Phase III trial for treatment of diabetes mellitus.
Krinal Barot, Vedika Thakkar, Devang Tandel, Gopi Patel, Rajesh Parmar, Kalpana Patel   +5 more
doaj   +1 more source

Addressing Current Challenges in Hydrogel Wound Dressing Strategies for Chronic Wound Management: Advances and Future Directions

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 4, April 2026.
ABSTRACT Given the market for chronic wound care, where wound dressings are the key product, it should go without saying that providing satisfactory wound dressings is critical. A wide variety of wound dressings have been developed. Hydrogel has drawn attention as a potential wound dressing for chronic wounds. Hydrogel may absorb large amounts of water
Gianna Fadhilah, Chen‐Ying Su, Hsu‐Wei Fang   +2 more
wiley   +1 more source

Efficacy and Safety of Glimepiride, Voglibose, and Metformin ER in Type 2 Diabetes: A Randomized, Active‐Controlled Study

Journal of Diabetes, Volume 18, Issue 4, April 2026.
Triple therapy with a fixed‐dose combination of Glimepiride+Voglibose+Metformin‐extended release in patients with Type 2 diabetes mellitus demonstrated better glycemic control compared to dual therapies. This combination was well‐tolerated with no increased risk of hypoglycemia, suggesting that Glimepiride+Voglibose+Metformin‐extended release could be ...
Brij Mohan, S. Vasanth Kumar, Prakash Harishchandra Kurmi, Sandeep Kumar Gupta, Neelaveni Kudugunti, Bharat Das, Kartikeya Parmar, Alok Kanungo, Sanjay Saran, Preetam Ahirrao Kashinath, Balamurugan Ramanathan, Micky Patel, Vivek Vedprakash Arya, Raisa Shaikh, Sapan Behera, Piyush Patel, Dipak Patil, Lalit Lakhwani, Pravin Ghadge, Suyog Mehta, Sadhna Joglekar   +20 more
wiley   +1 more source

Role of Colesevelam in Combination Lipid-Lowering Therapy [PDF]

, 2013
Hyperlipidemia is associated with an increased risk of cardiovascular events; reducing low-density lipoprotein cholesterol (LDL-C), the primary target for cholesterol-lowering therapy, lowers the risk for such events. Although bile acid sequestrants were
Michael R. Jones, Oliseyenum M. Nwose
core   +1 more source

Calebin A mitigates oxidative stress and inflammation in diabetic nephropathy via Nrf2/HO‐1 and NF‐κB signaling pathways

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 588-598, April 2026.
Representative histological images of kidney tissues stained with hematoxylin and eosin (H&E) at 400× magnification (n = 6). ABSTRACT Background Diabetic nephropathy (DN) is a common and serious microvascular complication of diabetes mellitus, primarily driven by persistent hyperglycemia‐induced oxidative stress and chronic inflammation.
Reyhane Ghayour Vatanparast, Mahdieh Aliyari, Mahla Palizkaran Yazdi, Soodeh Alidadi, Mohammad Reza Sokhanvar, Sercan Karav, Prashant Kesharwani, Hossein Hosseini, Amirhossein Sahebkar   +8 more
wiley   +1 more source

Toxicological and ecotoxicological risk‐based prioritization of pharmaceuticals in the natural environment [PDF]

, 2016
Approximately 1500 active pharmaceutical ingredients are currently in use; however, the environmental occurrence and impacts of only a small proportion of these have been investigated.
Agerstrand, Ashton, Boxall, Boxall, Capleton, Carter, Cooper, Crane, Dong, Drillia, Escher, Fick, Franco, Fu, Halling-Sorensen, Hirsch, Kidd, Kim, Kolpin, Kostich, Lahnsteiner, Laville, Monteiro, Niemuth, Ramirez, Roberts, Rocco, Roos, Sanderson, Santos, Schwab, Schwaiger, Sinclair, Triebskorn, Triebskorn, Wang, Webb, Zha   +37 more
core   +1 more source

Effect of metformin on pancreatic neuroendocrine tumors of multiple endocrine neoplasia type 1

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract Metformin is a widely prescribed medication in the management of type 2 diabetes mellitus, and numerous epidemiological studies have indicated an association between metformin use and a reduced risk of certain cancers in diabetic populations. However, evidence supporting a role for metformin in cancer prevention remains inconclusive. Exploring
Serguei V. Kozlov, Sunita K. Agarwal, Theresa M. Guerin, Wendi Custer Lawrence, Laura L. Bassel, Akua Graf, Smita Jha, Lee S. Weinstein, Jenny E. Blau, Jaydira del Rivero   +9 more
wiley   +1 more source

Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester [PDF]

, 2009
Objectives: Defective implantation is a mechanism for recurrent pregnancy loss (RPL). We sought to determine whether the serum expression of human relaxin-2 (RLX) is impaired in women with a history of RPL.
Bogic, Bogic, Carp, Craig, Dilly O.C. Anumba, Emmer, Gardosi, Goldsmith, Hollis, Jauniaux, Jivraj, Johnson, Johnson, Laird, MacLennan, Maynard, Mtiraoui, Nicolaides, Palomba, Parry, Petersen, Piccinni, Prakash, Saad El Gelany, Sakbun, Salim, Sarah L. Elliott, Seki, Tin C. Li, Unemori, Yki-Jarvinen   +30 more
core   +2 more sources

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, Volume 4, Issue 1, March 2026.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source