Results 71 to 80 of about 6,634 (171)

Plasma concentration of metformin and dexamethasone after administration through Osseogate

Drug Delivery, 2017
Background: Osseogate is a novel drug delivery route through bone marrow involving a modified implant used as the drug delivery system. The purpose of this study was to evaluate the effects of individual drug physicochemical characteristics on the ...
Hong-Kyun Kim, Young-Seok Park
doaj   +1 more source

A novel RP-HPLC approach for simultaneous determination of dapagliflozin, linagliptin, and metformin in pharmaceutical formulations

BMC Chemistry
A simple, precise, and stability-indicating reverse-phase high-performance liquid chromatography method was developed and validated for the simultaneous estimation of dapagliflozin, linagliptin, and metformin hydrochloride in fixed-dose combination ...
Samkit Shah, Rajendra Kotadiya
doaj   +1 more source

(Metformin-κ2N,N′)(salicylato-κ2O,O′)copper(II) trihydrate

IUCrData, 2018
The hydrous title complex [systematic name: (1,1-dimethylbiguanide-κ2N2,N4)(2-oxidobenzoato-κ2O,O′)copper(II) trihydrate], [Cu(C7H4O3)(C4H11N5)]·3H2O, was synthesized electrolytically from an ethanolic solution of metformin hydrochloride, acetylsalicylic
Sandra Julieta Gutiérrez Ojeda, Ulises Salazar Kuri, Sylvain Bernès, Aarón Pérez-Benítez   +3 more
doaj   +1 more source

Preliminary toxicological report of metformin hydrochloride loaded polymeric nanoparticles

Toxicology International, 2012
Nanosized materials have tremendous application in every field of human activity, with a lot of economic benefit increasing nanoparticle research and use. There are number of nanosized products already available commercially and many others are in queue.
Lekshmi, Unnikrishnan Meenakshi Dhana, Reddy, Pully Neelakanta   +1 more
openaire   +3 more sources

<b>Effect of binders on 500mg metformin hydrochloride tablets produced by wet granulation</b>

Revista de Ciências Farmacêuticas Básica e Aplicada, 2009
Metformin hydrochloride (MH) is an oral hypoglycemic agent and a high-dose drug that has poor flow and compression properties. In this study, the feasibility of developing adequate, low cost 500mg tablets of metformin hydrochloride by wet granulation was
LUCIANA CATIA BLOCK, LEONARDO OLIVEIRA SCHMELING, ANGELICA GARCIA COUTO, MARCOS ANTONIO SEGATTO, MONIKA P TAGLIARI, TANIA MARI BELLE BRESOLIN, SAMANTA CARDOZO MOURãO   +6 more
doaj  

Smartphone-Assisted Thin-Layer Chromatography for Rapid Quality Screening of Metformin

Advances in Pharmacological and Pharmaceutical Sciences
Type II diabetes remains a significant global public health issue, affecting both individual well-being and healthcare systems worldwide. Metformin hydrochloride is widely prescribed as the first-line treatment for managing diabetes.
Ram Kumar Bhattarai, Sanam Pudasaini, Toni Barstis, Basant Giri   +3 more
doaj   +1 more source

Potential Therapeutic Drugs for Parkinson’s Disease Based on Data Mining and Bioinformatics Analysis

Parkinson's Disease, 2018
The objective is to search potential therapeutic drugs for Parkinson’s disease based on data mining and bioinformatics analysis and providing new ideas for research studies on “new application of conventional drugs.” Method differential gene candidates ...
Chuan Xu, Jiajun Chen, Xia Xu, Yingyu Zhang, Jia Li   +4 more
doaj   +1 more source

Improved Chromatographic Separation of Sitagliptin Phosphate and Metformin Hydrochloride

International Journal of Biomedical Science, 2015
New UPLC method was developed for determination of sitagliptin and metformin using Symmetry C18 column (100 mm × 2.1 mm, 2.2 μm) and isocratic elution (methanol 20%), pH (3.5) as a mobile phase. The ultraviolet detector was operated at 220 nm and the column temperature was 50°C. Linearity parameters were acceptable over the concentration ranges of 2-12
openaire   +2 more sources

Novel Approach of Oxidative Coupling Reaction with 1-Naphthol of the Simultaneous Metformin Drug Determination in Either Pharmaceutics Formulations or Environmental Samples of Water Using Homemade CFIA- Merging Zones Techniques

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
A newly developed FIA-merging zones spectrophotometric system, the method is rapid, accurate and sensitive for metformin hydrochloride determination through the oxidation of 1- naphthol by sodium hypochlorite and coupling with metformin.HCl in the ...
Bushra Basheer Qassim
doaj  

Oral glucose-lowering drugs and long-term risk of benign prostatic hyperplasia

Consilium Medicum
Background. One of the most prominent threats for masculine health is comorbidity between benign prostatic hyperplasia (BPH) and diabetes mellitus type 2. Many publications suppose influence of hyperglycemia on lower urinary tract obstruction.
Stanislav N. Volkov, Robert K. Mikheev, Olga R. Grigoryan, Vitaliy I. Tereshchenko, Vladimir S. Stepanchenko, Elena N. Andreeva   +5 more
doaj   +1 more source