Results 61 to 70 of about 6,618 (171)

Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug

Journal of Pharmacy and Bioallied Sciences, 2020
Aim: This work shows the development of pulsatile capsular pellets of metformin hydrochloride and its characterisation. Material and Methods: The novel drug delivery system consisted of hydroxy propyl cellulose Type H.
Rahul Pandey, William Selvamurthy
doaj   +1 more source

Induction of IL‐9‐producing CD8+ T cells by ascochlorin derivatives

British Journal of Pharmacology, Volume 183, Issue 11, Page 3015-3031, June 2026.
A newly synthesised ascochlorin derivative, N184, induces small amounts of IL‐9‐producing CD8+ T cells. N184 improved the survival of CD8+ T cells and enhanced their antitumour activity, partially in an IL‐9‐dependent manner. The antitumour effect was completely dependent on IFNγ secretion rather than the cytotoxic activity of CD8+ T cells.
Natsumi Imano, Mikako Nishida, Miho Tokumasu, Weiyang Zhao, Nahoko Yamashita, Heiichiro Udono   +5 more
wiley   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, Volume 604, Issue 11, Page 4208-4224, 1 June 2026.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Comparing Hydroxypropyl Methylcellulose and Guar Gum on Sustained Release Effect of Metformin Hydrochloride Matrix Tablet [PDF]

Pharmaceutical and Biomedical Research
Background and Objectives: Limited diabetes drug availability and frequent adverse reactions to oral medications highlight the need for improved drug delivery. This study suggests optimizing drug efficiency through process modifications, focusing on anti-
Amlan Bishal, Biplab DEbnath, Bikash Gayen, Bratati Bandyopadhyay, Surjendu Payra, Rishav Maji, Kazi Asraf Ali   +6 more
doaj  

Safety of anagliptin/metformin combination tablets evaluated by non‐inferiority between pre‐ and post‐serum lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment (AMELIO STUDY)

Journal of Diabetes Investigation
Aims/Introduction To investigate the safety of anagliptin/metformin combination tablets by evaluation of lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment. Materials and Methods The participants of type 2 diabetes
Hiroshi Kajio, Ryotaro Bouchi, Mitsuhisa Komatsu, Masanori Yamazaki, Daisuke Takarabe, Masahide Okamoto, Takahisa Tanaka, Toru Kitazawa, Hisayuki Katsuyama, Yasumichi Mori, Mitsuhiko Noda   +10 more
doaj   +1 more source

Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2019
Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs.
Dewi Melani Hariyadi, Noorma Rosita, Tiara Jeni Rosadi   +2 more
doaj   +1 more source

Plasma concentration of metformin and dexamethasone after administration through Osseogate

Drug Delivery, 2017
Background: Osseogate is a novel drug delivery route through bone marrow involving a modified implant used as the drug delivery system. The purpose of this study was to evaluate the effects of individual drug physicochemical characteristics on the ...
Hong-Kyun Kim, Young-Seok Park
doaj   +1 more source

Preliminary toxicological report of metformin hydrochloride loaded polymeric nanoparticles

Toxicology International, 2012
Nanosized materials have tremendous application in every field of human activity, with a lot of economic benefit increasing nanoparticle research and use. There are number of nanosized products already available commercially and many others are in queue.
Lekshmi, Unnikrishnan Meenakshi Dhana, Reddy, Pully Neelakanta   +1 more
openaire   +3 more sources

A novel RP-HPLC approach for simultaneous determination of dapagliflozin, linagliptin, and metformin in pharmaceutical formulations

BMC Chemistry
A simple, precise, and stability-indicating reverse-phase high-performance liquid chromatography method was developed and validated for the simultaneous estimation of dapagliflozin, linagliptin, and metformin hydrochloride in fixed-dose combination ...
Samkit Shah, Rajendra Kotadiya
doaj   +1 more source

(Metformin-κ2N,N′)(salicylato-κ2O,O′)copper(II) trihydrate

IUCrData, 2018
The hydrous title complex [systematic name: (1,1-dimethylbiguanide-κ2N2,N4)(2-oxidobenzoato-κ2O,O′)copper(II) trihydrate], [Cu(C7H4O3)(C4H11N5)]·3H2O, was synthesized electrolytically from an ethanolic solution of metformin hydrochloride, acetylsalicylic
Sandra Julieta Gutiérrez Ojeda, Ulises Salazar Kuri, Sylvain Bernès, Aarón Pérez-Benítez   +3 more
doaj   +1 more source