Results 61 to 70 of about 6,634 (171)

Targeting Inflammaging: A Metformin‐Releasing Titanium Implant Reprograms Senescent Macrophages to Orchestrate Angiogenesis and Osteogenesis

Rare Metals, Volume 45, Issue 7, July 2026.
ABSTRACT Bone defect repair in elderly patients is frequently compromised by reduced osteogenic capacity and delayed healing. Chronic inflammation‐driven inflammaging is a critical contributor to this impairment, characterized by dysfunctional autophagy in senescent macrophages (S‐MΦs), excessive reactive oxygen species (ROS) accumulation, and ...
Ruiyue Hang, Ruoyu Di, Yuyu Zhao, Jiahui Wang, Xiaohong Yao, Ruiqiang Hang, Yin Xiao   +6 more
wiley   +1 more source

Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6207-6216, July 2026.
ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay, Ambanna Gowda, Manish Kumar Singh, A. Gopal Rao, Ramesh Duraisamy, Dinesh Gangwani, Jitendra Shukla, Vikas Agarwal, Sandesh Sahebarao Patil, Ambrish C., Satish Babu K. N., Arvind Palawat, Sandip Krishnrao Gofne, Abhay Kumar Sahoo, Pradeep Kumar Rai, Raisa Shaikh, Shruti Saha, Dipak Patil, Pravin Ghadge, Piyush Patel, Lalit Lakhwani, Suyog Mehta, Sadhna Joglekar   +22 more
wiley   +1 more source

Redirecting Alzheimer's disease therapeutics: Multitarget drugs and complementary non‐pharmacological strategies

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug‐development pipelines highlights the limited clinical impact of single‐target therapies and has increased interest in multi‐target approaches acting on shared biological hubs.
Humberto Martínez‐Orozco, Jesús Andrade‐Guerrero, Nelly Jovana Pastén‐Castrejón, Chryslaine Rodríguez‐Tanty, Sofía Y Diaz‐Miranda   +4 more
wiley   +1 more source

Some conceptual aspects and practice of Mohr method in the determination metformin hydrochloride in pharmaceutical formulations

Semina: Ciências Exatas e Tecnológicas, 2013
In this paper conceptual aspects and practices of Mohr method in the determination of metformin hydrochloride in pharmaceutical formulations are described. This experiment is simple and might be a good alternative to be applied in an experimental subject
Willian Toito Suarez, Elen Romão Sartori, Orlando Fatibello-Filho   +2 more
doaj   +1 more source

Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug

Journal of Pharmacy and Bioallied Sciences, 2020
Aim: This work shows the development of pulsatile capsular pellets of metformin hydrochloride and its characterisation. Material and Methods: The novel drug delivery system consisted of hydroxy propyl cellulose Type H.
Rahul Pandey, William Selvamurthy
doaj   +1 more source

Atom‐by‐Atom Multimetal CuMoP Deposition on Carbon Electrodes for Sensitive Antidiabetic Metformin Electrooxidation

Analytical Science Advances, Volume 7, Issue 1, June 2026.
An atom‐by‐atom ternary Cu–Mo–P nanocomposite is electrochemically co‐deposited onto screen‐printed carbon electrodes to create a highly active sensing interface for metformin detection. The porous mixed‐valence network enhances electroactive surface area and charge transfer, enabling sensitive and selective electrooxidation with a low detection limit.
Hong Wan, Mingfang Zhan, Chunyan Yin, Sima Akter, Sakil Mahmud   +4 more
wiley   +1 more source

Comparing Hydroxypropyl Methylcellulose and Guar Gum on Sustained Release Effect of Metformin Hydrochloride Matrix Tablet [PDF]

Pharmaceutical and Biomedical Research
Background and Objectives: Limited diabetes drug availability and frequent adverse reactions to oral medications highlight the need for improved drug delivery. This study suggests optimizing drug efficiency through process modifications, focusing on anti-
Amlan Bishal, Biplab DEbnath, Bikash Gayen, Bratati Bandyopadhyay, Surjendu Payra, Rishav Maji, Kazi Asraf Ali   +6 more
doaj  

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Drug Delivery, 2015
Metformin hydrochloride is a biguanide derivative widely used for the treatment of type 2 diabetes, prescribed nearly to 120 million people worldwide. Metformin has a relatively low oral bioavailability (about 50-60%). Although the major effect of metformin is to decrease hepatic glucose output as an antihyperglycemic agent, its inhibitory effects on ...
Çetin, Meltem, Şahin, Selma
openaire   +3 more sources

Safety of anagliptin/metformin combination tablets evaluated by non‐inferiority between pre‐ and post‐serum lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment (AMELIO STUDY)

Journal of Diabetes Investigation
Aims/Introduction To investigate the safety of anagliptin/metformin combination tablets by evaluation of lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment. Materials and Methods The participants of type 2 diabetes
Hiroshi Kajio, Ryotaro Bouchi, Mitsuhisa Komatsu, Masanori Yamazaki, Daisuke Takarabe, Masahide Okamoto, Takahisa Tanaka, Toru Kitazawa, Hisayuki Katsuyama, Yasumichi Mori, Mitsuhiko Noda   +10 more
doaj   +1 more source

Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2019
Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs.
Dewi Melani Hariyadi, Noorma Rosita, Tiara Jeni Rosadi   +2 more
doaj   +1 more source