Results 81 to 90 of about 13,870 (205)

Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction [PDF]

, 2010
PURPOSE: AMPK plays a crucial role in the regulation of the energy metabolism of the heart. During ischaemia, AMPK activation is a known adaptative prosurvival mechanism that helps to maintain the energy levels of the myocardium.
Davidson, SM, Gonçalves, L, Mocanu, MM, Paiva, MA, Providência, LA, Yellon, DM   +5 more
core   +2 more sources

A Natural Resource‐Based View of Circular Economy Practices in the Pharmaceutical Industry

Business Strategy and the Environment, Volume 35, Issue 3, Page 4587-4605, March 2026.
ABSTRACT Pharmaceutical industry is facing escalating environmental sustainability issues including gaseous emissions, waste generation, and excessive consumption of energy and non‐renewable materials. Nevertheless, the adoption of sustainable business models such as the circular economy (CE) is still in its infancy in this sector due to complex ...
Amna Farrukh, Muhammad Sohaib Sajjad
wiley   +1 more source

Some conceptual aspects and practice of Mohr method in the determination metformin hydrochloride in pharmaceutical formulations

Semina: Ciências Exatas e Tecnológicas, 2013
In this paper conceptual aspects and practices of Mohr method in the determination of metformin hydrochloride in pharmaceutical formulations are described. This experiment is simple and might be a good alternative to be applied in an experimental subject
Willian Toito Suarez, Elen Romão Sartori, Orlando Fatibello-Filho   +2 more
doaj   +1 more source

Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug

Journal of Pharmacy and Bioallied Sciences, 2020
Aim: This work shows the development of pulsatile capsular pellets of metformin hydrochloride and its characterisation. Material and Methods: The novel drug delivery system consisted of hydroxy propyl cellulose Type H.
Rahul Pandey, William Selvamurthy
doaj   +1 more source

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
core   +1 more source

Imeglimin Exerts Anti‐Tumor Activity in Multiple Myeloma Through Affecting Energy Metabolism and Downregulating IL‐16 Expression

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Imeglimin (IME) is a novel oral anti‐diabetic agent with a similar chemical structure to metformin, which has shown broad‐spectrum anti‐tumor activity. However, the activity of imeglimin on tumor cells remains unclear. This study investigated the effects of IME on multiple myeloma (MM) cells and explored the underlying mechanisms ...
Jifeng Jiang, Liang Ren, Yifeng Sun, Jing Li, Jiadai Xu, Aziguli Maihemaiti, Peng Liu   +6 more
wiley   +1 more source

Topical gel of Metformin solid lipid nanoparticles: a hopeful promise as a dermal delivery system [PDF]

, 2019
The aim of the present study was to enhance the skin delivery of metformin by making solid lipid nanoparticles containing metformin using the ultra-sonication method.
Akbari, Jafar, Morteza-Semnani, Katayoun, Nokhodchi, Ali, Rostamkalaei, Seyyed Sohrab, Saeedi, Majid   +4 more
core   +1 more source

Stimuli‐responsive hydrogels: An intelligent tool for wound management

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
For chronic and complex wounds, this review focuses on intelligent hydrogels capable of responding to wound microenvironmental cues (e.g., pH, enzymes) or external stimuli (e.g., light, electricity). These advanced materials enable the dynamic regulation of drug release and real‐time monitoring of healing progression, thereby offering innovative ...
Debin Zheng, Meiqi Zhu, Xi Liu, Cuiping Zhang, Di Wu, Tianyu Xie, Chen Li, Pei Zhao, Wenting Chen, Xiaobing Fu, Xiaoxue Li   +10 more
wiley   +1 more source

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Drug Delivery, 2015
Metformin hydrochloride is a biguanide derivative widely used for the treatment of type 2 diabetes, prescribed nearly to 120 million people worldwide. Metformin has a relatively low oral bioavailability (about 50-60%). Although the major effect of metformin is to decrease hepatic glucose output as an antihyperglycemic agent, its inhibitory effects on ...
Çetin, Meltem, Şahin, Selma
openaire   +3 more sources

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
core