Results 11 to 20 of about 26,256 (214)
Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation [PDF]
Allergy, Asthma & Clinical Immunology, 2020 Background Direct inhalation challenges (e.g. methacholine) are stated to be more sensitive and less specific for a diagnosis of asthma than are indirect challenges (e.g. exercise, non-isotonic aerosols, mannitol, etc.).
Donald W. Cockcroft +2 more
doaj +3 more sources
Methacholine challenge testing: comparative pharmacology
Journal of Asthma and Allergy, 2018 Beth E Davis, Christianne M Blais, Donald W Cockcroft Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada Abstract: Standardization of the methacholine inhalation challenge,
Davis BE, Blais CM, Cockcroft DW
doaj +4 more sources
Increasing Filamins A and B in Th2 Lymphocytes as a Therapeutic Opportunity to Attenuate Airway Inflammation in Mice. [PDF]
AllergyAllergy, Volume 81, Issue 4, Page 1297-1301, April 2026.
Chamy L +7 more
europepmc +2 more sources
Mannitol vs. methacholine in the evaluation of airway responsiveness in bakers’ asthma
International Journal of Occupational Medicine and Environmental Health, 2020 Objectives Various indirect or direct airway challenge tests are used to measure nonspecific bronchial hyper-responsiveness (NSBHR). The evaluation of NSBHR in diagnosing occupational asthma (OA) is performed, e.g., to monitor the specific inhalation ...
Ewa Nowakowska-Świrta +3 more
doaj +1 more source
, 2001 Clinical effects of spa therapy were examined in 150 patients with asthma in relation tobronchial hyperresponsiveness and patient age. 1. The efficacy rate of spa therapy was larger as the patient age was higher: the rate was 73.3% in patients under age ...
Ashida, Kozo +8 more
core +1 more source
European Journal of Medical Research, 2009 Introduction Bronchial challenge tests by inhalation of aerosolized methacholine (MCH) are commonly used in the clinical diagnosis of airway hyperresponsiveness (AHR). While the detection of airway narrowing relies on the patient's cooperation performing
Nensa F +4 more
doaj +1 more source
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]
, 2016 Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans +10 more
core +1 more source
Methacholine causes reflex bronchoconstriction [PDF]
Journal of Applied Physiology, 1999 To determine whether methacholine causes vagally mediated reflex constriction of airway smooth muscle, we administered methacholine to sheep either via the bronchial artery or as an aerosol via tracheostomy into the lower airways. We then measured the contraction of an isolated, in situ segment of trachealis smooth muscle and determined the effect of ...
E M, Wagner, D B, Jacoby
openaire +2 more sources
, 2004 The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1.
Ashida, Kozo +7 more
core +1 more source
Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]
, 2018 The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J. +14 more
core +1 more source