Results 41 to 50 of about 26,256 (214)

Measurement of Airway Responsiveness on Vigil and Unrestrained Mouse

Bio-Protocol, 2013
Airway hyperresponsiveness to methacholine is an important characteristic of asthma. This protocol describes how to measure airway response to methacholine in vigil and unrestraint mouse.
François Daubeuf, Laurent Reber, Nelly Frossard   +2 more
doaj   +1 more source

Challenges in interpreting allergen microarrays in relation to clinical symptoms: a machine learning approach. [PDF]

, 2013
Identifying different patterns of allergens and understanding their predictive ability in relation to asthma and other allergic diseases is crucial for the design of personalized diagnostic tools.Allergen-IgE screening using ImmunoCAP ISAC(®) assay was ...
Altmann, Beeh, Bolstad, Breiman, Burrows, Crapo, Custovic, Fayyad, Friedman, Gent, Huber, Knop, Marinho, Melioli, Millán, Murthy, Patelis, Semic-Jusufagic, Simpson, Simpson, Sordillo, Taylor, Wang   +22 more
core   +1 more source

Work‐Related Asthma From Exposure to Cardboard and Paper Products

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background We assess the contribution of cardboard dust exposure to the development of work‐related asthma (WRA). Prior studies on paper‐dust‐related breathing problems have focused on exposures in the paper milling and pulp industries. There have been no reports of asthma linked to workplace exposure to cardboard dust.
Mason E. Glanville, Mary Jo Reilly, Kenneth D. Rosenman   +2 more
wiley   +1 more source

Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma

Respiratory Research, 2009
Background Asthma can be difficult to diagnose, but bronchial provocation with methacholine, exercise or mannitol is helpful when used to identify bronchial hyperresponsiveness (BHR), a key feature of the disease.
Spector Sheldon L, Nichols Sara, Weiler John M, Charlton Brett, Anderson Sandra D, Pearlman David S   +5 more
doaj   +1 more source

What makes a difference in exercise-induced bronchoconstriction: an 8 year retrospective analysis. [PDF]

PLoS ONE, 2014
BACKGROUND: Exercise-induced bronchoconstriction (EIB) was recently classified into EIB alone and EIB with asthma, based on the presence of concurrent asthma.
Han-Ki Park, Jae-Woo Jung, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang   +4 more
doaj   +1 more source

Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways

Allergy, EarlyView.
Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen, Tessa Kole, Orestes A. Carpaij, Tatiana Karp, Victor Guryev, Alen Faiz, Kian Fan Chung, Pankaj Bhavsar, Ian M. Adcock, Salman Siddiqui, Andy Lan, Katie L. Raby, Nazanin Zounemat‐Kermani, Chris Brightling, Dave Singh, Janwillem Kocks, Monica Kraft, Bianca Beghé, Klaus F. Rabe, Alberto Papi, Machteld N. Hylkema, Martijn C. Nawijn, Maarten van den Berge   +22 more
wiley   +1 more source

Relationship between bronchial hyperreactivity and complete blood count derived inflammatory biomarkers

Gülhane Tıp Dergisi
Aims: Studies specifically linking bronchoprovocation test (BPT) positivity with complete blood count (CBC)-derived biomarkers are limited. We investigated the relationship between CBC-derived biomarkers and BPT positivity in this study.
Metin Keren, Eylem Tunçay, Fevzi Demirel   +2 more
doaj   +1 more source

More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?

Experimental Physiology, 2023
Mouse models are helpful in unveiling the mechanisms underlying sex disparities in asthma. In comparison to their female counterparts, male mice are hyperresponsive to inhaled methacholine, a cardinal feature of asthma that contributes to its symptoms ...
Rebecka Gill, Andrés Rojas‐Ruiz, Magali Boucher, Cyndi Henry, Ynuk Bossé   +4 more
doaj   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Differential effects of allergen challenge on large and small airway reactivity in mice. [PDF]

PLoS ONE, 2013
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to be fully assessed. This study used a mouse model of chronic allergic airways disease to induce inflammation and remodelling and determine whether in vivo ...
Chantal Donovan, Simon G Royce, James Esposito, Jenny Tran, Zaridatul Aini Ibrahim, Mimi L K Tang, Simon Bailey, Jane E Bourke   +7 more
doaj   +1 more source