Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients. [PDF]
PLoS Genetics, 2016 Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients.
Hsin-Chou Yang +7 more
doaj +2 more sources
Evaluating the effect of chronic and continuous use of methadone on the glomerular filtration rate of patients receiving oral methadone (syrup) [PDF]
Frontiers in MedicineIntroductionThis study systematically examines the effects of chronic oral methadone use on the glomerular filtration rate (GFR) in patients participating in methadone maintenance therapy (MMT) in Qazvin City, Iran.
Valiollah Goudarzvand Chegini +8 more
doaj +2 more sources
Toward precision prescribing for methadone: Determinants of methadone deposition.
PLoS ONE, 2020 BackgroundDespite the World Health Organization listing methadone as an essential medication, effective dose selection is challenging, especially in racial and ethnic minority populations.
Andrew H Talal +9 more
doaj +4 more sources
Harm Reduction Journal, 2023 Background During COVID-19, the Substance Abuse and Mental Health Services Administration (SAMHSA) allowed Methadone Maintenance Treatment (MMT) programs to relax in-person MMT requirements to reduce COVID-19 exposure.
Sarah Brothers +6 more
doaj +1 more source
A mathematical model of reward-mediated learning in drug addiction [PDF]
Chaos 32, 021102 (2022), 2022 Substances of abuse are known to activate and disrupt neuronal circuits in the brain reward system. We propose a simple and easily interpretable dynamical systems model to describe the neurobiology of drug addiction that incorporates the psychiatric concepts of reward prediction error (RPE), drug-induced incentive salience (IST), and opponent process ...
arxiv +1 more source
Interest without uptake: A mixed-methods analysis of methadone utilization in Kyrgyz prisons.
PLoS ONE, 2022 HIV incidence continues to increase in Eastern Europe and Central Asia (EECA), in large part due to non-sterile injection drug use, especially within prisons. Therefore, medication-assisted therapy with opioid agonists is an evidence-based HIV-prevention
Amanda R Liberman +8 more
doaj +1 more source
The nature of methadone diversion in England: a Merseyside case study
Harm Reduction Journal, 2012 Background Methadone maintenance treatment (MMT) is a key element in treatment for opiate addiction; however concerns about the diversion of methadone remain. More current empirical data on methadone diversion are required. This research investigated the
Duffy Paul, Baldwin Helen
doaj +1 more source
The SUMMIT trial: a field comparison of buprenorphine versus methadone maintenance treatment. [PDF]
, 2010 This prospective patient-preference study examined the effectiveness in practice of methadone versus buprenorphine maintenance treatment and the beliefs of subjects regarding these drugs. A total of 361 opiate-dependent individuals (89% of those eligible,
Holland, R +5 more
core +1 more source
Old Drugs for JAK-STAT Pathway Inhibition in COVID-19 [PDF]
, 2020 The pandemic threat of COVID-19 with more than 37 million cases in which about 5 percent entering critical stage characterized by cytokine storm and hyperinflammatory condition, the state more often leads to admission to intensive care unit with rapid mortality.
arxiv +1 more source
Harm Reduction Journal, 2017 Background Methadone maintenance therapy (MMT) is a mainstay for treating opioid use disorder and preventing and managing HIV among people who inject drugs (PWID).
Kanna Hayashi +6 more
doaj +1 more source