Results 1 to 10 of about 49,525 (269)

Hepatitis C virus infection influences the S-methadone metabolite plasma concentration. [PDF]

PLoS ONE, 2013
Heroin-dependent patients typically contract hepatitis C virus (HCV) at a disproportionately high level due to needle exchange. The liver is the primary target organ of HCV infection and also the main organ responsible for drug metabolism.
Shiow-Ling Wu, Sheng-Chang Wang, Hsiao-Hui Tsou, Hsiang-Wei Kuo, Ing-Kang Ho, Sheng-Wen Liu, Ya-Ting Hsu, Yao-Sheng Chang, Yu-Li Liu   +8 more
doaj   +1 more source

A Novel Use of the “3-Day Rule”: Post-discharge Methadone Dosing in the Emergency Department

Western Journal of Emergency Medicine
Introduction: Methadone is a medically necessary and lifesaving medication for many patients with opioid use disorder. To adequately address these patients’ needs, methadone should be offered in the hospital, but barriers exist that limit its ...
Jenna K. Nikolaides, Tran H. Tran, Elisabeth Ramsey, Sophia Salib, Henry Swoboda   +4 more
doaj   +1 more source

Higher methadone dose reduces risky drug injecting behaviours among methadone clients in Myanmar

Emerging Trends in Drugs, Addictions, and Health, 2021
Background: HIV prevalence rate among people who inject drugs (PWIDs) in Myanmar is marginally high (34.9%). HIV transmission can be reduced and prevented through harm reduction programs such as methadone maintenance treatment (MMT) and needle syringe ...
Sun Tun, B. Vicknasingam, Darshan Singh
doaj  

Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children

CPT: Pharmacometrics & Systems Pharmacology, 2021
Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined.
Blessed W. Aruldhas, Sara K. Quinney, Brian R. Overholser, Michael A. Heathman, Andrea R. Masters, Reynold C. Ly, Hongyu Gao, Senthil Packiasabapathy, Senthilkumar Sadhasivam   +8 more
doaj   +1 more source

Perceived barriers to methadone maintenance treatment among Iranian opioid users

International Journal for Equity in Health, 2018
Background Opioid use is a severe problem in Iran. Despite methadone maintenance treatment (MMT) programs being one of the most important treatment strategies for reducing individual and public harms associated with opioid use, a large proportion of ...
Maryam Khazaee-Pool, Maryam Moeeni, Koen Ponnet, Arezoo Fallahi, Leila Jahangiri, Tahereh Pashaei   +5 more
doaj   +1 more source

Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use.

PLoS ONE, 2020
Methadone is a synthetic opioid used as maintenance treatment for patients addicted to heroin. Skin irritation is one of the adverse events caused by opioid use.
Chiu-Ping Fang, Tung-Hsia Liu, Ren-Hua Chung, Hsiao-Hui Tsou, Hsiang-Wei Kuo, Sheng-Chang Wang, Chia-Chen Liu, Shu Chih Liu, Andrew C H Chen, Yu-Li Liu   +9 more
doaj   +1 more source

Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use

Journal of Research in Pharmacy Practice
Objective: Given the prevalence of methadone poisoning, this study was conducted to compare the cardiovascular complications following acute methadone poisoning in patients with and without a history of long-term methadone use.
Gholamali Dorooshi, Mahbod Shirmohammadi, Farzad Gheshlaghi, Arman Otroshi, Shafeajafar Zoofaghari, Nastaran Eizadi-Mood   +5 more
doaj   +1 more source

Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study

Cardiology and Therapy, 2019
Introduction Methadone is known to prolong the QT interval, which could induce lethal arrhythmias such as torsades de pointes. To determine the risk of ventricular arrhythmias in cancer patients using methadone, we measured QT dispersion (QTD) and Tpeak ...
Eriko Yamanaka, Satoru Chino, Toshifumi Takasusuki, Shinsuke Hamaguchi, Shigeki Yamaguchi   +4 more
doaj   +1 more source

Methadone Related Poisoning on the Rise in Tehran, Iran [PDF]

Asia Pacific Journal of Medical Toxicology, 2014
Background: In Iran, methadone has been used for methadone maintenance treatment (MMT) as well as analgesic treatment in pain clinics. Recently, there are some reports regarding accidental and intentional methadone poisonings and deaths.
Kambiz Soltaninejad, Hossein Hassanian-Moghaddam, Shahin Shadnia   +2 more
doaj  

Time to initiate randomized controlled clinical trials with methadone in cancer patients [version 2; peer review: 2 approved]

F1000Research, 2022
Public media coverage has fueled a demand for methadone as potential cure for cancer itself. Because patients have asked for respective prescriptions, clinical societies issued statements warning against the use of methadone as long as preclinical ...
Hans-Joachim Kremer
doaj