Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients. [PDF]
PLoS Genetics, 2016 Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients.
Hsin-Chou Yang +7 more
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Accidental Methadone Toxicity in a 3-Year-Old Leading to Severe Cerebellitis and Death: A Case Report [PDF]
Case Reports in PediatricsMethadone is a synthetic opioid used to treat pain and opioid dependence. Despite its benefits, accidental ingestion of methadone in pediatric patients can lead to significant morbidity and mortality.
Jessie Pappin, Greg Hansen, Tanya Holt
doaj +2 more sources
Intraoperative Methadone Versus Non-Methadone Analgesia in Pediatric Cardiac Surgery: A Retrospective Cohort Study [PDF]
ChildrenIntroduction: Methadone is an opioid-sparing opioid and it is increasingly used in children undergoing surgery due to its beneficial effects on postoperative pain scores, decreased opioid requirements, and fewer adverse effects compared to other opioids.
Brian Blasiole +7 more
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Toward precision prescribing for methadone: Determinants of methadone deposition.
PLoS ONE, 2020 BackgroundDespite the World Health Organization listing methadone as an essential medication, effective dose selection is challenging, especially in racial and ethnic minority populations.
Andrew H Talal +9 more
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Methadone-involved overdose deaths in urban and rural communities before and after the public health emergency flexibilities for methadone take-home doses [PDF]
Drug and Alcohol Dependence ReportsBackground: To mitigate COVID-19 exposure risks in methadone clinics, the Substance Abuse and Mental Health Services Administration (SAMHSA) issued a temporary modification of regulations in March 2020 to permit extended take-home methadone doses: up to ...
Rebecca Arden Harris +5 more
doaj +2 more sources
Cardiac Assessment of Individuals with Opioid Use Disorder under Methadone Treatment [PDF]
Journal of Research in Pharmacy PracticeObjective: Methadone treatment is effective for managing opioid use disorder (OUD) but raises concerns about its impact on cardiac function. This study aimed to assess the prevalence of cardiac dysfunction among individuals under methadone treatment ...
Hoda Barkhordari +4 more
doaj +2 more sources
Harm Reduction Journal, 2023 Background During COVID-19, the Substance Abuse and Mental Health Services Administration (SAMHSA) allowed Methadone Maintenance Treatment (MMT) programs to relax in-person MMT requirements to reduce COVID-19 exposure.
Sarah Brothers +6 more
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Canadian Family Physician, 2021 As a pharmacist who has been dispensing methadone for more than 20 years to patients in and out of Ontario provincial jails, I read the article by Raski et al in the November issue[1][1] with interest (and gratitude to one of the doctors on our team, who thoughtfully clipped this article out of ...
openaire +3 more sources
Interest without uptake: A mixed-methods analysis of methadone utilization in Kyrgyz prisons.
PLoS ONE, 2022 HIV incidence continues to increase in Eastern Europe and Central Asia (EECA), in large part due to non-sterile injection drug use, especially within prisons. Therefore, medication-assisted therapy with opioid agonists is an evidence-based HIV-prevention
Amanda R Liberman +8 more
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Psychopathology and urine toxicology in methadone patients
Mental Illness, 2015 Several studies reported high rates of psychiatric commorbidity among methadone patients. We examined the relationships of measures of psychopathology to outcomes of screening urine tests for cocaine, opiates, and benzodiazepines in a sample of 56 ...
Gamal Sadek, Zack Cernovsky, Simon Chiu
doaj +1 more source