Results 21 to 30 of about 126,285 (384)

d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i

Scientific Reports, 2021
The search continues for improved therapy for acute lymphoblastic leukemia (aLL), the most common malignancy in children. Recently, d,l-methadone was put forth as sensitizer for aLL chemotherapy.
JungKwon Lee, Jesusa L. Rosales, Hee-Guk Byun, Ki-Young Lee   +3 more
doaj   +1 more source

The experience of long-term opiate maintenance treatment and reported barriers to recovery: A qualitative systematic review [PDF]

, 2013
Background/Aim: To inform understanding of the experience of long-term opiate maintenance and identify barriers to recovery. Methods: A qualitative systematic review.
Annie Blyth, Bahna G, Ball JC, Berridge V, Caitlin Notley, Conner KO, De Maeyer J, De Maeyer J, De Maeyer J, Gibson B, Gold ML, Gossop M, Gourlay J, Higgins J, Jarvinen M, Jarvinen M, Jean Craig, McIntosh J, McKeganey N, Moher D, Neale J, Pani PP, Parsons T, Peles E, Richard Holland, Rosenbaum M, Segall A, Skinner ML, Sun AP, Vigilant LG, Vigilant LG, Vivienne Maskrey   +31 more
core   +1 more source

Estimate cost of providing methadone maintenance treatment at a methadone clinic in Nairobi Kenya: direct costs

The Pan African Medical Journal, 2021
Methadone maintenance treatment is reported as cost-effective in treatment of opioid use disorder. Estimated cost of providing methadone varies widely in different regions but there is no data regarding cost of methadone treatment in Kenya.
Brenda Mogaka1, Sarah Kanana Kiburi, Mirriam Mutinda, Maxwel Kendagor   +3 more
doaj   +1 more source

Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis [PDF]

, 2014
<b>Background</b><p></p> It is assumed within the accumulated literature that children born of pregnant opioid dependent mothers have impaired neurobehavioral function as a consequence of chronic intrauterine opioid use.<p>&
A Baldacchino, A Liberati, A Ornoy, A Sameroff, A Verdejo-Garcia, AJ Dunlop, Alex Baldacchino, American Psychiatric Association, B Hanson, BJ Cleary, Britannica, C Konijnenberg, C Konijnenberg, Colin McCowan, DE Hutchings, Dennis J Petrie, Department of Health (England) and the devolved administrations, DF Stroup, E Rotheram-Fuller, E Strauss, EK Emory, FM Wolf, GJ Demakis, H Cooper, HC Steinhausen, HE Jones, HE Jones, I Fihrer, I van Beusekom, IM Bernstein, J Cohen, J Cohen, J Keegan, J Kimber, J Prosser, JE Hunter, JN Whitham, JP Higgins, K Spiteri Cornish, Kathleen Arbuckle, KB Walhovd, KD Ersche, KK Zakzanis, L Manchikanti, L McGlone, LV Hedges, LV Hedges, LW Anderson, M Borenstein, M Borenstein, M Connock, M Farrell, M Grattan, M Pirastu, MD Lezak, MM de Cubas, National Collaborating Centre for Methods and Tools, NICE, NICHD, PS Bauman, R Bunikowski, R Cornish, R Hamilton, R King, RE Johnson, RG Orwin, RJ Sternberg, RW Hunt, S Darke, S Minozzi, S Salo, S Simeons, S Soepatmi, S Tong, Scottish Government, SL Grace, SL Hans, SL Hans, SM Petterson, SM Quinhana, SR Kandall, TB Huedo-Medina, TJ Ornstein, TS Rosen, V Moe, WH Organization, WK Lombardo   +86 more
core   +11 more sources

Barriers to retention in methadone maintenance therapy among people who inject drugs in Bangkok, Thailand: a mixed-methods study

Harm Reduction Journal, 2017
Background Methadone maintenance therapy (MMT) is a mainstay for treating opioid use disorder and preventing and managing HIV among people who inject drugs (PWID).
Kanna Hayashi, Lianping Ti, Prempreeda Pramoj Na Ayutthaya, Paisan Suwannawong, Karyn Kaplan, Will Small, Thomas Kerr   +6 more
doaj   +1 more source

Simultaneous determination of methadone and morphine at a modified electrode with 3D β-MnO2 nanoflowers: application for pharmaceutical sample analysis

RSC Advances, 2020
The present research synthesized manganese dioxide nano-flowers (β-MnO2-NF) via a simplified technique for electro-catalytic utilization. Moreover, morphological characteristics and X-ray analyses showed Mn in the oxide form with β-type crystallographic ...
S. Akbari, S. Jahani, M. Foroughi, Hadi Hassani Nadiki   +3 more
semanticscholar   +1 more source

Methadone for prisoners [PDF]

The Lancet, 2016
1 Rich JD, McKenzie M, Larney S, et al. Methadone continuation versus forced withdrawal on incarceration in a combined US prison and jail: a randomised, open-label trial. Lancet 2015; 386: 350–59. 2 Kershnar S. A defense of retributivism. Int J Appl Philos 2000; 14: 97–117. 3 Gewirtz P. Methadone maintenance for heroin addicts.
Daniel D’Hotman, Daniel D’Hotman, Thomas Douglas, Jonathan Pugh   +3 more
openaire   +6 more sources

Commune Health Workers' Methadone Maintenance Treatment (MMT) Knowledge and Perceived Difficulties Providing Decentralized MMT Services in Vietnam. [PDF]

, 2017
BackgroundWith the initial establishment of countrywide methadone maintenance therapy (MMT) system, Vietnam is in the process of expanding and decentralizing the MMT program to community-based healthcare settings.ObjectiveThe study aimed to measure the ...
Li, Li, Lin, Chunqing, Tuan, Nguyen Anh
core   +2 more sources

The Effect of CYP2B6, CYP2D6, and CYP3A4 Alleles on Methadone Binding: A Molecular Docking Study

Journal of Chemistry, 2013
Current methadone maintenance therapy (MMT) is yet to ensure 100% successful treatment as the optimum dosage has yet to be determined. Overdose leads to death while lower dose causes the opioid withdrawal effect.
Nik Nur Syazana Bt Nik Mohamed Kamal, Theam Soon Lim, Gee Jun Tye, Rusli Ismail, Yee Siew Choong   +4 more
doaj   +1 more source

The challenge of perioperative pain management in opioid-tolerant patients [PDF]

, 2017
The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F, Coluzzi, Flaminia, Corcione, A., Cuomo, A, Dauri, M, Leonardi, C, Melotti, Rm, Natoli, S, Romualdi, P, Savoia, G   +9 more
core   +2 more sources