Results 21 to 30 of about 130,679 (320)

d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i

Scientific Reports, 2021
The search continues for improved therapy for acute lymphoblastic leukemia (aLL), the most common malignancy in children. Recently, d,l-methadone was put forth as sensitizer for aLL chemotherapy.
JungKwon Lee, Jesusa L. Rosales, Hee-Guk Byun, Ki-Young Lee   +3 more
doaj   +1 more source

Barriers to retention in methadone maintenance therapy among people who inject drugs in Bangkok, Thailand: a mixed-methods study

Harm Reduction Journal, 2017
Background Methadone maintenance therapy (MMT) is a mainstay for treating opioid use disorder and preventing and managing HIV among people who inject drugs (PWID).
Kanna Hayashi, Lianping Ti, Prempreeda Pramoj Na Ayutthaya, Paisan Suwannawong, Karyn Kaplan, Will Small, Thomas Kerr   +6 more
doaj   +1 more source

Estimate cost of providing methadone maintenance treatment at a methadone clinic in Nairobi Kenya: direct costs

The Pan African Medical Journal, 2021
Methadone maintenance treatment is reported as cost-effective in treatment of opioid use disorder. Estimated cost of providing methadone varies widely in different regions but there is no data regarding cost of methadone treatment in Kenya.
Brenda Mogaka1, Sarah Kanana Kiburi, Mirriam Mutinda, Maxwel Kendagor   +3 more
doaj   +1 more source

Toxicological Analysis of Some Drugs of Abuse in Biological Samples [PDF]

, 2015
Consumption of drugs of abuse is a scourge of modern world. Abuse, drug addiction and their consequences are one of the major current problems of European society because of the significant repercussions in individual, family, social and economic level ...
Baconi, Daniela Luiza, Bârcă, Maria, Bălălău, Cristian, Ciobanu, Anne Marie, Negrei, Carolina, Stan, Miriana   +5 more
core   +3 more sources

Understanding concurrent stimulant use among people on methadone: A qualitative study.

Drug and Alcohol Review, 2020
INTRODUCTION AND AIMS Opioid-related overdoses are an epidemic in North America, prompting a greater use of medications for opioid use disorder, such as methadone.
R. McNeil, Nitsaha Puri, Jade Boyd, Samara Mayer, K. Hayashi, W. Small   +5 more
semanticscholar   +1 more source

The SUMMIT trial: a field comparison of buprenorphine versus methadone maintenance treatment. [PDF]

, 2010
This prospective patient-preference study examined the effectiveness in practice of methadone versus buprenorphine maintenance treatment and the beliefs of subjects regarding these drugs. A total of 361 opiate-dependent individuals (89% of those eligible,
Holland, R, Maskrey, V, Pinto, H, Rumball, D, Swift, L, Wagle, A   +5 more
core   +1 more source

Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry

bioRxiv, 2020
Despite the rising prevalence of methadone treatment in pregnant women with opioid use disorder, the effects of methadone on neurobehavioral development remain unclear.
Gregory G. Grecco, Briana E Mork, Jui-Yen Huang, Corinne E. Metzger, D. Haggerty, Kaitlin C. Reeves, Yong Gao, Hunter Hoffman, S. Katner, A. Masters, Cameron W. Morris, Erin A Newell, E. Engleman, A. Baucum, Jieun Kim, B. Yamamoto, M. Allen, Yu-chien Wu, Hui-Chen Lu, Patrick L. Sheets, Brady K. Atwood   +20 more
semanticscholar   +1 more source

Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis [PDF]

, 2014
<b>Background</b><p></p> It is assumed within the accumulated literature that children born of pregnant opioid dependent mothers have impaired neurobehavioral function as a consequence of chronic intrauterine opioid use.<p>&
A Baldacchino, A Liberati, A Ornoy, A Sameroff, A Verdejo-Garcia, AJ Dunlop, Alex Baldacchino, American Psychiatric Association, B Hanson, BJ Cleary, Britannica, C Konijnenberg, C Konijnenberg, Colin McCowan, DE Hutchings, Dennis J Petrie, Department of Health (England) and the devolved administrations, DF Stroup, E Rotheram-Fuller, E Strauss, EK Emory, FM Wolf, GJ Demakis, H Cooper, HC Steinhausen, HE Jones, HE Jones, I Fihrer, I van Beusekom, IM Bernstein, J Cohen, J Cohen, J Keegan, J Kimber, J Prosser, JE Hunter, JN Whitham, JP Higgins, K Spiteri Cornish, Kathleen Arbuckle, KB Walhovd, KD Ersche, KK Zakzanis, L Manchikanti, L McGlone, LV Hedges, LV Hedges, LW Anderson, M Borenstein, M Borenstein, M Connock, M Farrell, M Grattan, M Pirastu, MD Lezak, MM de Cubas, National Collaborating Centre for Methods and Tools, NICE, NICHD, PS Bauman, R Bunikowski, R Cornish, R Hamilton, R King, RE Johnson, RG Orwin, RJ Sternberg, RW Hunt, S Darke, S Minozzi, S Salo, S Simeons, S Soepatmi, S Tong, Scottish Government, SL Grace, SL Hans, SL Hans, SM Petterson, SM Quinhana, SR Kandall, TB Huedo-Medina, TJ Ornstein, TS Rosen, V Moe, WH Organization, WK Lombardo   +86 more
core   +12 more sources

The Effect of CYP2B6, CYP2D6, and CYP3A4 Alleles on Methadone Binding: A Molecular Docking Study

Journal of Chemistry, 2013
Current methadone maintenance therapy (MMT) is yet to ensure 100% successful treatment as the optimum dosage has yet to be determined. Overdose leads to death while lower dose causes the opioid withdrawal effect.
Nik Nur Syazana Bt Nik Mohamed Kamal, Theam Soon Lim, Gee Jun Tye, Rusli Ismail, Yee Siew Choong   +4 more
doaj   +1 more source

Commune Health Workers' Methadone Maintenance Treatment (MMT) Knowledge and Perceived Difficulties Providing Decentralized MMT Services in Vietnam. [PDF]

, 2017
BackgroundWith the initial establishment of countrywide methadone maintenance therapy (MMT) system, Vietnam is in the process of expanding and decentralizing the MMT program to community-based healthcare settings.ObjectiveThe study aimed to measure the ...
Li, Li, Lin, Chunqing, Tuan, Nguyen Anh
core   +2 more sources