Results 21 to 30 of about 121,985 (386)

Understanding concurrent stimulant use among people on methadone: A qualitative study.

Drug and Alcohol Review, 2020
INTRODUCTION AND AIMS Opioid-related overdoses are an epidemic in North America, prompting a greater use of medications for opioid use disorder, such as methadone.
R. McNeil, Nitsaha Puri, Jade Boyd, Samara Mayer, K. Hayashi, W. Small   +5 more
semanticscholar   +1 more source

Factors associated with strong opioid use for noncancer pain in patients with chronic intestinal failure

Nutrition in Clinical Practice, Volume 38, Issue 1, Page 129-137, February 2023., 2023
Abstract Background Chronic analgesic use is described in home parenteral nutrition (HPN)–dependent patients, but there are limited data on factors associated with opioid use for noncancerous pain. Methods Patients attending a national UK intestinal failure reference center were divided in two groups according to strong opioid (SO) usage; risk factors ...
Liat Deutsch, Anabelle Cloutier, Gavin Leahy, Antje Teubner, Arun Abraham, Michael Taylor, Peter Paine, Simon Lal   +7 more
wiley   +1 more source

Predicting the correct dose in children: Role of computational Pediatric Physiological‐based pharmacokinetics modeling tools

CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 13-26, January 2023., 2023
Abstract The pharmacokinetics (PKs) and safety of medications in particular groups can be predicted using the physiologically‐based pharmacokinetic (PBPK) model. Using the PBPK model may enable safe pediatric clinical trials and speed up the process of new drug research and development, especially for children, a population in which it is relatively ...
Xu Zhou, Jiening Dun, Xiao Chen, Bai Xiang, Yunjie Dang, Deying Cao   +5 more
wiley   +1 more source

Tissue sealing versus suture ligation in open canine ovariectomy: Surgical times, intraoperative nociceptive response and frequency of complications

Veterinary Medicine and Science, Volume 9, Issue 1, Page 76-81, January 2023., 2023
Abstract Background In this study, we compared two different techniques currently used for open canine ovariectomy: traditional method utilising absorbable suture and vessel sealing device (ENSEAL® Ethicon Endo‐Surgery, Cincinnati, OH). Objectives The aim of this study was to compare the surgical times, intraoperative nociceptive response and the ...
Vincenzo Cicirelli, Matteo Burgio, Alice Carbonari, Giovanni M Lacalandra, Giulio G Aiudi   +4 more
wiley   +1 more source

Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence.

Cochrane Database of Systematic Reviews, 2008
BACKGROUND Buprenorphine has been reported as an alternative to methadone for maintenance treatment of opioid dependence, but differing results are reported concerning its relative effectiveness indicating the need for an integrative review ...
R. Mattick, J. Kimber, C. Breen, M. Davoli   +3 more
semanticscholar   +1 more source

d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i

Scientific Reports, 2021
The search continues for improved therapy for acute lymphoblastic leukemia (aLL), the most common malignancy in children. Recently, d,l-methadone was put forth as sensitizer for aLL chemotherapy.
JungKwon Lee, Jesusa L. Rosales, Hee-Guk Byun, Ki-Young Lee   +3 more
doaj   +1 more source

Sedative and antinociceptive effects of different combinations of detomidine and methadone in standing horses [PDF]

, 2017
Objective To evaluate intravenous (IV) detomidine with methadone in horses to identify a combination which provides sedation and antinociception without adverse effects. Study design Randomized, placebo-controlled, blinded, crossover.
Crosignani, N, Gozalo-Marcilla, M, Luna, S P L, Pelligand, L, Possebon, F S, Puoli Filho, J N P, Taylor, P M   +6 more
core   +1 more source

MultiBUGS: A parallel implementation of the BUGS modelling framework for faster Bayesian inference [PDF]

Journal of Statistical Software, 95(7), 2020, 2017
MultiBUGS (https://www.multibugs.org) is a new version of the general-purpose Bayesian modelling software BUGS that implements a generic algorithm for parallelising Markov chain Monte Carlo (MCMC) algorithms to speed up posterior inference of Bayesian models.
arxiv   +1 more source

The Effect of CYP2B6, CYP2D6, and CYP3A4 Alleles on Methadone Binding: A Molecular Docking Study

Journal of Chemistry, 2013
Current methadone maintenance therapy (MMT) is yet to ensure 100% successful treatment as the optimum dosage has yet to be determined. Overdose leads to death while lower dose causes the opioid withdrawal effect.
Nik Nur Syazana Bt Nik Mohamed Kamal, Theam Soon Lim, Gee Jun Tye, Rusli Ismail, Yee Siew Choong   +4 more
doaj   +1 more source

Psychopathology and urine toxicology in methadone patients

Mental Illness, 2015
Several studies reported high rates of psychiatric commorbidity among methadone patients. We examined the relationships of measures of psychopathology to outcomes of screening urine tests for cocaine, opiates, and benzodiazepines in a sample of 56 ...
Gamal Sadek, Zack Cernovsky, Simon Chiu
doaj   +1 more source