Results 1 to 10 of about 108,717 (194)

Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors

open access: yesFrontiers in Psychiatry, 2021
Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention.
Tamara J. Phillips   +8 more
doaj   +1 more source

Consecutive treatments of methamphetamine promote the development of cardiac pathological symptoms in zebrafish.

open access: yesPLoS ONE, 2023
Chronic methamphetamine use, a widespread drug epidemic, has been associated with cardiac morphological and electrical remodeling, leading to the development of numerous cardiovascular diseases.
Jimmy Zhang   +7 more
doaj   +1 more source

Association Between Alexithymia, Social Support, and Duration of Methamphetamine Use Among Male Methamphetamine-Dependent Patients

open access: yesFrontiers in Psychiatry, 2021
Introduction: China has 1.18 million methamphetamine abusers. Among the illegal drugs in China, methamphetamine has the highest abuse rate. Although previous studies have indicated a positive relationship between alexithymia and declining social support,
Shu Cui   +12 more
doaj   +1 more source

Patterns of and Rationale for the Co-use of Methamphetamine and Opioids: Findings From Qualitative Interviews in New Mexico and Nevada

open access: yesFrontiers in Psychiatry, 2022
IntroductionMethamphetamine use and methamphetamine-involved deaths have increased dramatically since 2015, and opioid-related deaths now frequently involve methamphetamine.
Brittany D. Rhed   +6 more
doaj   +1 more source

Altered dental plaque microbiota correlated with salivary inflammation in female methamphetamine users

open access: yesFrontiers in Immunology, 2022
Poor oral health is the most immediate and overlooked hazard of methamphetamine abuse in humans. Previous studies have reported methamphetamine-associated alterations in saliva microbiota, but the cause of methamphetamine-induced alterations in the oral ...
Zhuohang Deng   +7 more
doaj   +1 more source

A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor

open access: yesFrontiers in Pharmacology, 2018
Major gene effects on traits associated with substance use disorders are rare. Previous findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary MA intake, and in null mutants demonstrate a major impact of the trace amine-
Cheryl Reed   +8 more
doaj   +1 more source

Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence [PDF]

open access: yes, 2017
We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation.
Bossert, Jennifer M.   +6 more
core   +2 more sources

Reciprocal Substitution Between Methamphetamine and Heroin in Terms of Reinforcement Effects in Rats

open access: yesFrontiers in Psychiatry, 2020
Heroin and methamphetamine are both popular illicit drugs in China. Previous clinical data showed that habitual users of either heroin or methamphetamine abuse the other drug for substitution in case of unavailability of their preferred drug. The present
Di-sen Mei   +9 more
doaj   +1 more source

Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

open access: yeseLife, 2019
We identified a locus on mouse chromosome 10 that accounts for 60% of the genetic variance in methamphetamine intake in mice selectively bred for high versus low methamphetamine consumption. We nominated the trace amine-associated receptor 1 gene, Taar1,
Alexandra M Stafford   +9 more
doaj   +1 more source

The clinical pharmacology of intranasal l-methamphetamine. [PDF]

open access: yes, 2008
BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 ...
Everhart, Tom   +6 more
core   +2 more sources

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