Methimazole-induced reproductive endocrine system disruption and hepatotoxicity: insights from a Trichogaster trichopterus animal model [PDF]
BMC Pharmacology and ToxicologyBackground Methimazole is commonly prescribed for managing hyperthyroidism, although concerns regarding its reproductive and hepatic adverse effects persist. This study aimed to evaluate the dose-dependent effects of methimazole on reproductive endocrine
Mahdi Ahmadinia +2 more
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Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves’ Disease [PDF]
Endocrinology and Metabolism, 2022 Background An excess of thyroid hormones in Graves’ disease (GD) has profound effects on systemic energy metabolism that are currently partially understood.
Ho Yeop Lee +9 more
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Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect.
Reza Heidari +3 more
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The Role of Endoplasmic Reticulum Stress in Cell Injury Induced by Methimazole on Pancreatic Cells [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: Methimazole is an anti-thyroid agent, especially as main therapy option for Graves’ disease in children and adults. Drug induced pancreatitis is one of the known adverse effect of methimazole mentioned in case reports.
Özge Yazıcı +3 more
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Cytoprotective Effects of Organosulfur Compounds against Methimazole-Induced Toxicity in Isolated Rat Hepatocytes [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Methimazole is a drug widely used in hyperthyroidism. However, life-threatening hepatotoxicity has been associated with its clinical use. No protective agent has been found to be effective against methimazole-induced hepatotoxicity yet.
Mohammad Ali Eghba +2 more
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Colorimetric Determination of Thioamide Drugs Based on the Surface Plasmon Resonance Band of Colloidal Silver Nanoparticles [PDF]
شیمی کاربردی روز, 2013 In this article, we report a new method for the determination of two thioamide drugs, propylthiouracil (PTU) and methimazole (MMZ), with unmodified silver nanoparticles (AgNPs).
Jafar Abolhasani +3 more
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Frontiers in Endocrinology, 2021 BackgroundHyperthyroidism is related to vascular atherosclerosis. Propylthiouracil (PTU) and methimazole, other than their antithyroid effects, may have different mechanisms in preventing atherogenesis in Graves’ disease.ObjectiveThis study aimed to ...
Wismandari Wisnu +9 more
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Efficacy and adverse events related to the initial dose of methimazole in children and adolescents with Graves’ disease [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Purpose The first-line antithyroid drug for children and adolescents with Graves’ disease (GD) is methimazole (MMI). This study evaluated the relationship between the initial MMI dose and the clinical course of GD after treatment.
Hyun Gyung Lee +2 more
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Zinc(II)-methimazole complexes: synthesis and reactivity [PDF]
, 2015 The tetrahedral S-coordinated complex [Zn(MeImHS)(4)](ClO4)(2), synthesised from the reaction of [Zn(ClO4)(2)] with methimazole (1-methyl-3H-imidazole-2-thione, MeImHS), reacts with triethylamine to yield the homoleptic complex [Zn(MeImS)(2)] (MeImS ...
Aragoni M C +9 more
core +1 more source
Preparation of Au@Ir/C as sensor for Methimazole Detection
International Journal of Electrochemical Science, 2018 Au@Ir/C nanocomposite as an electroactive material for methimazole detection has been synthesized via polyol reduction method. Physical tests demonstrate that ultrafine nanoparticles of Au@Ir composite (2-4 nm) are evenly dispersed on carbon.
Si Chen +8 more
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