Results 41 to 50 of about 13,190 (162)

Thyroid dysfunction alters gut microbiota composition and alveolar bone levels in female mice

Physiological Reports, Volume 14, Issue 6, March 2026.
Abstract Thyroid hormone dysfunction has been implicated in both bone metabolism and gut microbial composition, yet the interplay between thyroid status, gut microbiota, and alveolar bone homeostasis remains unclear. In this study, female C57BL/6J mice were treated with triiodothyronine (T3) and thyroxine (T4) to induce hyperthyroidism or with ...
Lucia Thompson, Brailey Coulter, Cinnamon VanPutte   +2 more
wiley   +1 more source

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

ChemistryEurope, Volume 4, Issue 2, February 2026.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña, Zeyu Feng, David Herrero, Martin Simon, Christopher Golz, Manuel Alcarazo   +5 more
wiley   +1 more source

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. [PDF]

, 2016
Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-).
Ahmad, Ahn, Carlson, Carrasco, Carrasco, Carrasco, Carrasco, Carrasco, Clarke, Desai, Dirbas, Dominguez, Gambhir, Gonzalez-Angulo, Grollman, Harrington, Haveman, Ikeda, Jhiang, Jhiang, Jhiang, Kalkanis, Kang, Kirova, Lawrence, Lawrence, Lind, Link, Liu, Lorusso, Mier, Morris, Neuwelt, Nishimura, Russell, Schlumberger, Seidman, Smith, Spitzweg, Steeg, Studebaker, Vermorken, Vermorken, Wapnir, Wapnir, Wapnir, Wapnir   +46 more
core   +1 more source

A Case of IgG4‐Related Disease Developing During Long‐Term High‐Dose Intravenous Epoprostenol Therapy in a Patient With Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Long‐term intravenous (IV) epoprostenol is a key therapy for pulmonary arterial hypertension (PAH); however, rare immune‐mediated conditions occurring during therapy remain incompletely characterised. We report a 34‐year‐old man with idiopathic PAH who developed low‐grade fever and bilateral pulmonary infiltrates after 11 years of IV ...
Takashi Inao, Kazuhiko Nakayama, Shintaro Yasui, Nanami Shite, Eriko Shiraki, Chiho Ohbayashi, Kojiro Otsuka, Hiroyuki Onishi, Soichiro Ohta, Masanori Iwahashi   +9 more
wiley   +1 more source

Effects of thyroid status and thyrostatic drugs on hepatic glucuronidation of lodothyronines and other substrates in rats - Induction of phenol UDP-glucuronyltransferase by methimazole [PDF]

, 1995
Glucuronidation of iodothyronines in rat liver is catalyzed by at least three UDP-glucuronyltransferases (UGTs): bilirubin UGT, phenol UGT, and androsterone UGT.
Bonthuis, F. (Fred), Cannon, M.L. (Mark), Gijzel, A.L. (Anthonie), Greef, W.J. (W.) de, Herder, W.W. (Wouter) de, Kaptein, E. (Ellen), Visser, T.J. (Theo)   +6 more
core   +2 more sources

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

Journal of Internal Medicine, Volume 299, Issue 1, Page 126-142, January 2026.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro, Isabel Solares, Daniel Jericó, Francisco J. Castelbón, Javier Tomás Solera, Antoni Riera‐Mestre, María Barreda‐Sánchez, Carlo Poci, Annamaria Nicolli, Francesco Urigo, Ana Sampedro, Rafael Enríquez de Salamanca, Matteo Marcacci, Matías A. Ávila, Pauline Harper, Marta G. Fanlo‐Maresma, Encarna Guillén‐Navarro, Giovanna Graziadei, Andrea Wenzel, Bodo B. Beck, Paolo Ventura, Montserrat Morales‐Conejo, Antonio Fontanellas   +22 more
wiley   +1 more source

Epidemiology and Clinical Outcomes of HTLV‐1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Human T‐lymphotropic virus Type 1 (HTLV‐1) is a globally distributed, oncogenic retrovirus endemic in specific regions, including southwestern Japan, sub‐Saharan Africa, the Caribbean, parts of South America (notably Brazil), Iran, and Indigenous communities in Australia. Although most infections are asymptomatic, a minority of carriers develop severe,
Bezhan Noori, Ramin Shahbahrami, Yousef Douzandegan, Sayed-Hamidreza Mozhgani, Mehdi Norouzi, Seyed Mohammad Jazayeri, Arif Ansori   +6 more
wiley   +1 more source

Projected reduction in healthcare costs in Belgium after optimization of iodine intake : impact on costs related to thyroid nodular disease [PDF]

, 2010
Background: Several surveys in the last 50 years have repeatedly indicated that Belgium is affected by mild iodine deficiency. Within the framework of the national food and health plan in Belgium, a selective, progressive, and monitored strategy was ...
Annemans, Lieven, Moreno-Reyes, Rodrigo, Tafforeau, Jean, Van Oyen, Herman, Vandevijvere, Stefanie   +4 more
core   +1 more source

Thyroid Storm in a Hypothyroid Patient: A Case Report of Concurrent Graves′ Disease and Hashimoto′s Thyroiditis

Case Reports in Critical Care, Volume 2026, Issue 1, 2026.
Thyroid storm, a life‐threatening endocrine emergency, is exceptionally rare in patients with hypothyroidism. This case highlights the unique challenge of diagnosing and managing thyroid storm in the context of concurrent Graves′ disease and Hashimoto′s thyroiditis, a paradoxical coexistence of autoimmune thyroid disorders.
Katrina Villegas, Rouba Isshak, Mubarak Yusuf, Mourad Ismail, Konstantinos Leou, Lipi Buch   +5 more
wiley   +1 more source

Thyroid Storm at Sea: A Case Report of Algae‐Induced Thyrotoxicosis

Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.
Iodine‐induced thyrotoxicosis (IIT), also known as the Jod‐Basedow phenomenon, is a rare yet recognized cause of hyperthyroidism. While iodinated contrast is the most frequent trigger, iodine‐rich supplements such as seaweed products or supplements can also precipitate thyrotoxicosis, particularly in individuals with prior chronic iodine deficiency or ...
Alynna Knaub, Amanda Cecchini, John Janousek, Laura Strojny, Jairo Noreña, Zachary Pawlikowski, Kalyani Sen   +6 more
wiley   +1 more source