Results 171 to 180 of about 291,831 (295)

Ubiquitination in cancer: mechanisms and therapeutic opportunities

open access: yesCancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu   +7 more
wiley   +1 more source

5‐thiohistidine N‐acetyltransferase from Proteiniphilum saccharofermentans

open access: yesChemBioChem, Accepted Article.
Ovothiol A is a 5‐thiohistidine derivative biosynthesized by a broad range of prokaryotic and eukaryotic organisms. Its redox‐active mercaptoimidazole side chain is believed to protect cells from oxidative stress. The three enzymes that produce ovothiol A from histidine, cysteine, and S‐adenosyl methionine have been identified and characterized.
Cangsong Liao   +3 more
wiley   +1 more source

Metabolism of Methionine and Pectin Esterification in a Plant Tissue

open access: hybrid, 1958
Clifford S. Sato   +3 more
openalex   +1 more source

2‐oxoglutarate analogue‐based biomolecular tools for exploring structure‐activity relationships in non‐heme iron enzymes

open access: yesChemBioChem, Accepted Article.
2‐oxoglutarate (2OG)‐dependent non‐heme iron (NHFe) enzymes constitute a family of enzymes that use 2OG and oxygen to catalyze the hydroxylation of unactivated C(sp3)–H bonds. These enzymes are of biological importance and therapeutic interest due to their role in regulating various cellular processes. Herein, we have rationally designed two classes of
Peter Windsor   +3 more
wiley   +1 more source

A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations

open access: yesChemBioChem, EarlyView.
Site‐specifically phosphorylated isoforms of the tumor suppressor p53 – encompassing all seven known phosphorylation sites within the TAD1 domain –are created upon optimization of semisynthesis protocols. This “designer" p53 library enabled validation of phosphorylation‐specific p53 antibodies and revealed epitope masking by phosphorylation in commonly
Mateusz Hess   +6 more
wiley   +1 more source

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