Results 171 to 180 of about 607,306 (389)
Pectin Metabolism Influences Phloem Architecture and Flowering Time in Arabidopsis Thaliana
Advanced Science, EarlyView.Cell wall remodeling mediated by changes in pectic homogalacturonan, including its methyl‐esterification status and degradation, shapes wall architecture. This study finds that pectin metabolism dynamically modulates wall properties and triggers auxin responses, which influence phloem morphogenesis and function, mediating the long‐distance transport of
Qing Zhang +9 more
wiley +1 more source
A Multi‐Property Optimizing Generative Adversarial Network for de novo Antimicrobial Peptide Design
Advanced Science, EarlyView.A Multi‐Property Optimizing Generative Adversarial Network (MPOGAN) is proposed to iteratively learn the relationship between peptides and multiple properties using a dynamically dataset. As the quality of the dataset improves, MPOGAN's ability to design antimicrobial peptides (AMPs) with multiple desired properties is enhanced.
Jiaming Liu +16 more
wiley +1 more source
Advanced Science, EarlyView.The Species Search Engine (KISSE) is a novel statistical approach for identifying species from collagen peptides, using a curated library of sequences and their relative abundances derived from shotgun proteomics. Abstract DNA and bone collagen are two key sources of resilient molecular markers used to identify species from their remains.
Hassan Gharibi +8 more
wiley +1 more source
Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins. [PDF]
, 2018 Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other
Barry, Natasha A +5 more
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DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training
Advanced Science, EarlyView.DeepSecMS, a deep learning platform leveraging a Cys‐to‐Sec proxy training strategy, enhances the identification of known selenoproteins and holds promise for discovering novel candidates. This proxy approach overcomes limitations associated with the rarity of known selenoproteins and demonstrates broad applicability in studying other rare protein ...
Chenfang Si +5 more
wiley +1 more source
The efficacy of choline as an adjuvant in the therapy of Laennec's cirrhosis [PDF]
, 1951 Thesis (M.D.)—Boston ...
Bednarz, Wallace
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Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source
A microbiological method for the determination of choline by use of a mutant of Neurospora [PDF]
, 1943 Previous communications from this laboratory have described the production of biochemical mutants in the mold Neurospora by means of ultraviolet and x-rays (1, 2).
Beadle, G. W., Horowitz, N. H.
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Metabolism of Methionine and Pectin Esterification in a Plant Tissue
, 1958 Clifford S. Sato +3 more
openalex +1 more source
Advanced Science, EarlyView.This study investigates plasma metabolomic biomarkers for rheumatoid arthritis (RA) development using longitudinal data from 209 RA patients and 56 individuals at risk. It also reveals metabolic signatures linked to severity, age, sex, and anti‐citrullinated protein autoantibody in RA.
Chenxi Zhu +21 more
wiley +1 more source