Results 11 to 20 of about 122,610 (155)

Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Nature Communications, 2023
Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-
P. Upadhyayula, Dominique M. O. Higgins, Angeliki Mela, M. Banu, Athanassios Dovas, Fereshteh Zandkarimi, P. Patel, A. Mahajan, N. Humala, T. Nguyen, K. Chaudhary, Li Liao, Michael G. Argenziano, T. Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, C. Kinslow, L. Ye, M. Siegelin, Simon K. Cheng, R. Soni, J. Bruce, B. Stockwell, P. Canoll   +24 more
semanticscholar   +1 more source

Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade

Nature Communications, 2023
Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy and immunotherapy are unknown.
Ying Xue, F. Lu, Zhenzhen Chang, Jing Li, Yuan Gao, Jie Zhou, Ying Luo, Yong-Ji Lai, Siyuan Cao, Xiaoxiao Li, Yuhan Zhou, Yan Li, Z. Tan, Xiang Cheng, Xiong Li, Jing Chen, Weimin Wang   +16 more
semanticscholar   +1 more source

Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts

Gut, 2022
Objective Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA methylation and antitumour immunity are molecularly ...
Ting Li, Yue Tan, Yanxing Chen, Xiaojun Zheng, Wen Wang, Kun Liao, Hai-Yu Mo, Junzhong Lin, Wei Yang, Hai-long Piao, Ruifeng Xu, Huai-qiang Ju   +11 more
semanticscholar   +1 more source

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Nature, 2020
Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours1–4, but the cause of this link is unknown. Here we show that tumour cells disrupt methionine metabolism in CD8+ T cells, thereby lowering intracellular levels of ...
Yingjie Bian, Wei Li, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Z. Nwosu, Li Zhang, A. Czerwonka, A. Pawlowska, Houjun Xia, Jing Li, P. Liao, Jiali Yu, Linda Vatan, Wojciech Szeliga, Shuang Wei, Sara Grove, J. Liu, K. McLean, M. Cieslik, A. Chinnaiyan, W. Zgodziński, G. Wallner, I. Wertel, K. Okła, Ilona Kryczek, C. Lyssiotis, W. Zou   +28 more
semanticscholar   +1 more source

The Level of Methionine Residues in Storage Proteins Is the Main Limiting Factor of Protein-Bound-Methionine Accumulation in Arabidopsis Seeds

Frontiers in Plant Science, 2020
The low level of methionine, an essential sulfur-containing amino acid, limits the nutritional quality of seeds. Two main factors can control the level of protein-bound methionine: the level of free methionine that limits protein accumulation and the ...
Aiswarya Girija, David Shotan, David Shotan, Yael Hacham, Yael Hacham, Rachel Amir, Rachel Amir   +6 more
doaj   +1 more source

Enhancement of performance and anti-oxidant variables in broiler chicken fed diets containing sub-optimal methionine level with graded concentrations of sulphur and folic acid [PDF]

Animal Bioscience, 2022
Objective An experiment was conducted to determine the effects of supplementing graded concentrations of inorganic sulphur (S) without and with folic acid (FA) in maize-soybean meal diets on performance, slaughter and anti-oxidant variables, immune ...
Venkata Rama Rao Savaram, Venkata Lakshmi Narasimha Raju Mantena, Shyam Sunder Paul, Nagalakshmi Devanaboyina, Srilatha Thota, Prakash Bhukya, Rajkumar Ullengala   +6 more
doaj   +1 more source

The Effect of Sulfur and Cow Manure on Yield, Yield components and amino acids of Sesame Cultivars (Sesamum indicum L.) [PDF]

Journal of Agricultural Science and Sustainable Production, 2022
Background and Objective: This research was conducted to determine the effect of sulfur and cattle manure on yield and amino acids of two Sesame (Sesamum indicum L.) varieties.
Marjan saiedinejad, Mohammad Ali Behdani, Mohammadhassan sayari, Sohrab Mahmoodi   +3 more
doaj   +1 more source

Methionine Dependence of Cancer

Biomolecules, 2020
Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from oxidative phosphorylation to predominantly glycolytic pathways to support rapid growth is well known and is often referred to as the Warburg effect.
P. Kaiser
semanticscholar   +1 more source

Comparison of: (2S,4R)-4-[18F]Fluoroglutamine, [11C]Methionine, and 2-Deoxy-2-[18F]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems Imaging Rat Gliomas

Frontiers in Oncology, 2021
PurposeThe three positron emission tomography (PET) imaging compounds: (2S,4R)-4-[18F]Fluoroglutamine ([18F]FGln), L-[methyl-11C]Methionine ([11C]Met), and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) were investigated to contrast their ability to image ...
Maxwell W. G. Miner, Heidi Liljenbäck, Heidi Liljenbäck, Jenni Virta, Semi Helin, Olli Eskola, Petri Elo, Jarmo Teuho, Kerttu Seppälä, Vesa Oikonen, Guangli Yang, Andrea Kindler-Röhrborn, Heikki Minn, Heikki Minn, Xiang-Guo Li, Xiang-Guo Li, Anne Roivainen, Anne Roivainen, Anne Roivainen, Anne Roivainen   +19 more
doaj   +1 more source

Methionine Restriction and Cancer Biology

Nutrients, 2020
The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents.
D. Wanders, K. Hobson, X. Ji
semanticscholar   +1 more source