Results 11 to 20 of about 607,306 (389)

Methionine Dependence of Cancer [PDF]

Biomolecules, 2020
Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from oxidative phosphorylation to predominantly glycolytic pathways to support rapid growth is well known and is often referred to as the Warburg effect.
Peter Kaiser
doaj   +6 more sources

Sensing and Signaling of Methionine Metabolism

Metabolites, 2021
Availability of the amino acid methionine shows remarkable effects on the physiology of individual cells and whole organisms. For example, most cancer cells, but not normal cells, are hyper dependent on high flux through metabolic pathways connected to ...
Linda Lauinger, Peter Kaiser
doaj   +2 more sources

Carboxy-Methylation of the Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Integrates Methionine Availability with Methionine Addicted Cancer Cell Proliferation [PDF]

Biomolecules
Cancer cells exhibit a well-documented, yet poorly understood, dependence on exogenous methionine, despite retaining the capacity to convert homocysteine to methionine.
Anna Andronicos, Kiku C. Yoneda, Da-Wei Lin, Fiona V. Law, Hosung Bae, Ali Basirattalab, Nicholas A. Graham, Cholsoon Jang, Peter Kaiser   +8 more
doaj   +2 more sources

METHIONINE STUDIES [PDF]

Journal of Biological Chemistry, 1939
Joseph J. Kolb, Gerrit Toennies
openalex   +5 more sources

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy

iScience, 2022
Summary: Methionine addiction, found in all types of cancer investigated, is because of the overuse of methionine by cancer cells for excess transmethylation reactions. In the present study, we compared the histone H3 lysine-methylation status and degree
Jun Yamamoto, Sachiko Inubushi, Qinghong Han, Yoshihiko Tashiro, Norihiko Sugisawa, Kazuyuki Hamada, Yusuke Aoki, Kentaro Miyake, Ryusei Matsuyama, Michael Bouvet, Steven G. Clarke, Itaru Endo, Robert M. Hoffman   +12 more
doaj   +1 more source

Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Nature Communications, 2023
Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-
P. Upadhyayula, Dominique M. O. Higgins, Angeliki Mela, M. Banu, Athanassios Dovas, Fereshteh Zandkarimi, P. Patel, A. Mahajan, N. Humala, T. Nguyen, K. Chaudhary, Li Liao, Michael G. Argenziano, T. Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, C. Kinslow, L. Ye, M. Siegelin, Simon K. Cheng, R. Soni, J. Bruce, B. Stockwell, P. Canoll   +24 more
semanticscholar   +1 more source

Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade

Nature Communications, 2023
Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy and immunotherapy are unknown.
Ying Xue, F. Lu, Zhenzhen Chang, Jing Li, Yuan Gao, Jie Zhou, Ying Luo, Yong-Ji Lai, Siyuan Cao, Xiaoxiao Li, Yuhan Zhou, Yan Li, Z. Tan, Xiang Cheng, Xiong Li, Jing Chen, Weimin Wang   +16 more
semanticscholar   +1 more source

A bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses

Nature Communications, 2023
Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we construct a synergistic nanoplatform to promote CD8+ T cell infiltration in
Ying Huang, Geng Qin, Tingting Cui, Chuanqi Zhao, Jinsong Ren, Xiaogang Qu   +5 more
semanticscholar   +1 more source

L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson’s Disease

Antioxidants, 2021
Methionine is an aliphatic, sulfur-containing, essential amino acid that has been demonstrated to have crucial roles in metabolism, innate immunity, and activation of endogenous antioxidant enzymes, including methionine sulfoxide reductase A/B and the ...
Mariano Catanesi, Laura Brandolini, Michele d’Angelo, Elisabetta Benedetti, Maria Grazia Tupone, Margherita Alfonsetti, Enrico Cabri, Daniela Iaconis, Maddalena Fratelli, Annamaria Cimini, Vanessa Castelli, Marcello Allegretti   +11 more
doaj   +1 more source

Synergy of Combining Methionine Restriction and Chemotherapy: The Disruptive Next Generation of Cancer Treatment.

Cancer Diagnosis & Prognosis, 2023
All cancer cell types are methionine-addicted, which is termed the Hoffman effect. Cancer cells, unlike normal cells, cannot survive without large amount of methionine.
Y. Kubota, Qinghong Han, Y. Aoki, Noriyuki Masaki, K. Obara, K. Hamada, Chihiro Hozumi, A. C. Wong, M. Bouvet, T. Tsunoda, R. Hoffman   +10 more
semanticscholar   +1 more source