Methionine adenosyltransferase I/III deficiency: beyond the central nervous system manifestations [PDF]
Therapeutics and Clinical Risk Management, 2018 Marwan Nashabat,1 Sultan Al-Khenaizan,2 Majid Alfadhel1 1King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, Division of Genetics, Department of Pediatrics, King Abdulaziz Medical City, Ministry ...
Nashabat M, Al-Khenaizan S, Alfadhel M
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Impact of glutathione supplementation of parenteral nutrition on hepatic methionine adenosyltransferase activity [PDF]
Redox Biology, 2016 Background: The oxidation of the methionine adenosyltransferase (MAT) by the combined impact of peroxides contaminating parenteral nutrition (PN) and oxidized redox potential of glutathione is suspected to explain its inhibition observed in animals.
Wesam Elremaly +3 more
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Role of methionine adenosyltransferase genes in hepatocarcinogenesis. [PDF]
Cancers (Basel), 2011 Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Detection of HCC can be difficult, as most of the patients who develop this tumor have no symptoms other than those related to their longstanding liver disease. There is an urgent need to understand the molecular mechanisms that are responsible for the development ...
Ramani K, Mato JM, Lu SC.
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Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions [PDF]
Scientific Reports, 2017 Methionine adenosyltransferase (MAT) is involved in folate-mediated one-carbon metabolism, which is essential for preimplantation embryos in terms of both short-term periconceptional development and long-term phenotypic programming beyond the ...
Shuntaro Ikeda +4 more
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The role of forkhead box M1-methionine adenosyltransferase 2 A/2B axis in liver inflammation and fibrosis [PDF]
Nature CommunicationsMethionine adenosyltransferase 2 A (MAT2A) and MAT2B are essential for hepatic stellate cells (HSCs) activation. Forkhead box M1 (FOXM1) transgenic mice develop liver inflammation and fibrosis. Here we examine if they crosstalk in male mice.
Bing Yang +22 more
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Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytesResearch in context [PDF]
EBioMedicine, 2019 Background: Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials.
Jing Bai +17 more
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Biosynthesis of S-Adenosylmethionine by Magnetically Immobilized Escherichia coli Cells Highly Expressing a Methionine Adenosyltransferase Variant [PDF]
Molecules, 2017 S-Adenosylmethionine (SAM) is a natural metabolite having important uses in the treatment of various diseases. To develop a simple and effective way to produce SAM, immobilized Escherichia coli cells highly expressing an engineered variant of methionine ...
Chunli Yin, Tao Zheng, Xin Chang
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Methionine Adenosyltransferase Inhibitors for the Treatment of Cancer. [PDF]
ACS Med Chem Lett, 2021 Kargbo RB.
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Determination of Autosomal Dominant or Recessive Methionine Adenosyltransferase I/III Deficiencies Based on Clinical and Molecular Studies [PDF]
Molecular Medicine, 2016 Methionine adenosyltransferase (MAT) I/III deficiency can be Inherited as autosomal dominant (AD) or as recessive (AR) traits in which mono- or biallelic MAT1A mutations have been identified, respectively.
Yoo-Mi Kim +11 more
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Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer
Journal for ImmunoTherapy of Cancer, 2021 Background The activation of tumor-associated macrophages (TAMs) facilitates the progression of gastric cancer (GC). Cell metabolism reprogramming has been shown to play a vital role in the polarization of TAMs. However, the role of methionine metabolism
Xi Yang +7 more
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