Results 21 to 30 of about 3,813 (143)
Methionine adenosyltransferases in liver cancer [PDF]
World Journal of Gastroenterology, 2019 Methionine adenosyltransferases (MATs) are essential enzymes for life as they produce S-adenosylmethionine (SAMe), the biological methyl donor required for a plethora of reactions within the cell. Mammalian systems express two genes, MAT1A and MAT2A, which encode for MATα1 and MATα2, the catalytic subunits of the MAT isoenzymes, respectively.
Murray, Ben +4 more
openaire +3 more sources
Regulation of Mammalian Liver Methionine Adenosyltransferase [PDF]
The Journal of Nutrition, 2002 S-adenosylmethionine (SAM) is an essential metabolite in all cells. SAM is the most important biological methyl group donor and is a precursor in the synthesis of polyamines. Methionine adenosyltransferase (MAT; EC 2.5.1.6) catalyzes the only known SAM biosynthetic reaction from methionine and ATP.
Latasa, M.U. (María Ujué) +10 more
openaire +3 more sources
Structure-function relationships in methionine adenosyltransferases [PDF]
Cellular and Molecular Life Sciences, 2008 Methionine adenosyltransferases (MATs) are the family of enzymes that synthesize the main biological methyl donor, S-adenosylmethionine. The high sequence conservation among catalytic subunits from bacteria and eukarya preserves key residues that control activity and oligomerization, which is reflected in the protein structure.
G D, Markham, M A, Pajares
openaire +2 more sources
Leishmania donovani methionine adenosyltransferase [PDF]
European Journal of Biochemistry, 2002 Junta de Castilla y ...
Pérez Pertejo, Maria Yolanda +6 more
openaire +5 more sources
iScience, 2023 Summary: Methionine adenosyltransferase 1a (MAT1A) is responsible for hepatic S-adenosyl-L-methionine (SAMe) biosynthesis. Mat1a−/− mice have hepatic SAMe depletion, develop nonalcoholic steatohepatitis (NASH) which is reversed with SAMe administration ...
Aaron E. Robinson +16 more
doaj +1 more source
Characterisation of methionine adenosyltransferase from
BMC Microbiology, 2003 Background Tuberculosis remains a serious world-wide health threat which requires the characterisation of novel drug targets for the development of future antimycobacterials.
Knodel Marvin H, Berger Bradley J
doaj +1 more source
Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
Cell Death Discovery, 2022 N6-methyladenosine (m6A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris ...
Runjiao Zhang +10 more
doaj +1 more source
Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA
Signal Transduction and Targeted Therapy, 2022 Folic acid, served as dietary supplement, is closely linked to one-carbon metabolism and methionine metabolism. Previous clinical evidence indicated that folic acid supplementation displays dual effect on cancer development, promoting or suppressing ...
Jin-Tao Li +15 more
doaj +1 more source
Cell Reports, 2017 Summary: S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA and histone methylation, tuning regulation of gene expression. Appropriate intracellular SAM levels must be maintained, because methyltransferase reaction rates
Hiroki Shima +9 more
doaj +1 more source
Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis
BMC Cancer, 2022 Background Glioma-initiating cells (GICs) are the source of glioma cells that can self-renew, have pluripotency, and are treatment-resistant, so are the starting point for relapse and eventual death despite multimodality therapy.
Kiyotaka Yokogami +6 more
doaj +1 more source