Results 31 to 40 of about 3,813 (143)

Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice

Redox Biology, 2022
The metastasis-associated lung adenocarcinoma transcript1 (MALAT1) is a long noncoding RNA (lncRNA) and is known for its role in cancer development and prognosis.
Jingshu Chen, Shu Tang, Sui Ke, James J. Cai, Daniel Osorio, Andrei Golovko, Benjamin Morpurgo, Shaodong Guo, Yuxiang Sun, Melanie Winkle, George A. Calin, Yanan Tian   +11 more
doaj   +1 more source

S-adenosylmethionine metabolism and liver disease

Annals of Hepatology, 2013
Methionine is an essential amino acid that is metabolized mainly by the liver where it is converted to S-adenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase.
José M. Mato, M. Luz Martínez-Chantar, Shelly C. Lu   +2 more
doaj   +1 more source

Hydrogen Peroxide-Based Fluorometric Assay for Real-Time Monitoring of SAM-Dependent Methyltransferases

Frontiers in Bioengineering and Biotechnology, 2018
Methylated chemicals are widely used as key intermediates for the syntheses of pharmaceuticals, fragrances, flavors, biofuels and plastics. In nature, the process of methylation is commonly undertaken by a super-family of S-adenosyl methionine-dependent ...
M. Kalim Akhtar, M. Kalim Akhtar, Dhanya Vijay, Saima Umbreen, Chris J. McLean, Yizhi Cai, Dominic J. Campopiano, Gary J. Loake   +7 more
doaj   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling. [PDF]

Cancer Commun (Lond)
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Tang R, Sun Y, Deng A, Liu J, Dai P, Chen J, Deng C, Liu H, Hai Y, Tong Y, Du YE, Liu M, Luo H.   +12 more
europepmc   +2 more sources

Methionine adenosyltransferases in liver health and diseases

Liver Research, 2017
Methionine adenosyltransferases (MATs) are essential for cell survival because they catalyze the biosynthesis of the biological methyl donor S-adenosylmethionine (SAMe) from methionine and adenosine triphosphate (ATP). Mammalian cells express two genes, MAT1A and MAT2A, which encode two MAT catalytic subunits, α1 and α2, respectively.
Ramani, Komal, Lu, Shelly C
openaire   +5 more sources

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. [PDF]

PLoS ONE, 2015
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in NAFLD are not fully understood.
Tommy Pacana, Sophie Cazanave, Aurora Verdianelli, Vaishali Patel, Hae-Ki Min, Faridoddin Mirshahi, Eoin Quinlivan, Arun J Sanyal   +7 more
doaj   +1 more source

Confirmation that MAT1A p.Ala259Val mutation causes autosomal dominant hypermethioninemia

Molecular Genetics and Metabolism Reports, 2017
Methionine adenosyltransferase (MAT) I/III deficiency is an inborn error of metabolism caused by mutations in MAT1A, encoding the catalytic subunit of MAT responsible for the synthesis of S-adenosylmethionine, and is characterized by persistent ...
Michael J. Muriello, Sarah Viall, Teodoro Bottiglieri, Kristina Cusmano-Ozog, Carlos R. Ferreira   +4 more
doaj   +1 more source

Mutational analysis of methionine adenosyltransferase from Leishmania donovani [PDF]

European Journal of Biochemistry, 2004
The methionine adenosyltransferase (MAT; EC 2.5.1.6) mediated synthesis of S‐adenosylmethionine (AdoMet) is a two‐step process, consisting of the formation of AdoMet and the subsequent cleavage of the tripolyphosphate (PPPi) molecule, a reaction induced, in turn, by AdoMet.
Pérez Pertejo, Maria Yolanda, Reguera Torres, Rosa María, García Estrada, Carlos, Balaña Fouce, Rafael, Ordóñez, David   +4 more
openaire   +4 more sources

Specific interaction of methionine adenosyltransferase with free radicals [PDF]

BioFactors, 1998
AbstractAlthough free radicals have been traditionally implicated in cell injury, and associated to pathophysiological processes, recent data implicate them in cell signaling events. Free radicals are naturally occurring oxygen‐, nitrogen‐ and sulfur‐derived species with an unpaired electron, such as superoxide, hydroxyl radical or nitric oxide.
Corrales, F.J. (Fernando José), Ruiz, F.A. (Félix A.), Avila, M.A. (Matías Antonio), Carretero, M.V. (M. Victoria), Sanchez-Gongora, E. (E.), Mingorance, J. (J.), Mato, J.M. (José María)   +6 more
openaire   +3 more sources

Changes in the Levels of Methionine Adenosyltransferase, Methionine Sulfoxide Reductase A, and Thioredoxin are Associated with Oxidative Stress in Patients with Hyperthyroidism

Diyala Journal of Medicine
Background: Hyperthyroidism is associated with increased oxidative stress and alterations in enzymatic and non-enzymatic antioxidant systems. Methionine adenosyltransferase (MAT) plays a key role in cellular metabolism and may be involved in redox ...
Marwa A. Al-Badrany, Luay A. Al-Helaly
doaj   +1 more source