Results 101 to 110 of about 348,762 (206)

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Genetic polymorphisms in folate metabolism and their association with recurrent spontaneous abortion

The Journal of Maternal-Fetal & Neonatal Medicine
Objective This study aims to investigate the relationship between polymorphisms in key enzyme genes involved in folate metabolism and recurrent spontaneous abortion (RSA).Methods Genotypic data and red blood cell folate levels were collected from 150 ...
Ai-Ning Wu, Rong-Xin Yu, Kui-Wei Song, Ya Tuo   +3 more
doaj   +1 more source

Multiplexed Nanosensors for Real‐Time Monitoring of VOC‐Mediated Signalling Response in Plants

Plant, Cell &Environment, Volume 49, Issue 12, Page 9907-9931, December 2026.
ABSTRACT To enhance crop performance, intercropping strategies leverage volatile organic compound (VOC)‐driven interactions with companion plants that constitutively emit VOCs. Despite the agricultural importance, the mechanisms and kinetics of VOC‐mediated sensory transduction in receiver plants eavesdropping on neighbouring non‐kin emitters remain ...
Mervin Chun‐Yi Ang, Jolly Madathiparambil Saju, Sayyid Mohaideen, Niha Dhar, Sarangapani Sreelatha, Sayuj Koyyappurath, Thomas K. Porter, Gabriel Sánchez‐Velázquez, Vaishnavi Reddy Amarr, Song Wang, Duc Thinh Khong, Suh In Loh, Michael S. Strano, Sarojam Rajani   +13 more
wiley   +1 more source

Molecular Insight into the Effect of a Single-Nucleotide Polymorphic Variation on the Structure and Dynamics of Methionine Synthase Reductase and Its Association with Neural Tube Defects. [PDF]

ACS Omega, 2021
Sadhukhan S, Maity S, Chakraborty S, Paul S, Munian D, Pattanayak AK, Jana B, Das M, Das M.   +8 more
europepmc   +1 more source

Integration of Chemical Probes and Degradomics Reveals That Cathepsin B Functions Primarily as a Dipeptidyl Carboxypeptidase in Macrophages

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
An integrated chemical biology and degradomics approach reveals the proteolytic landscape of cathepsin B in mouse macrophages. Z‐RK‐AOMK perturbs the cysteine cathepsin network and reveals that cathepsin B predominantly exhibits dipeptidyl carboxypeptidase activity in cells.
Kai‐Qi Yek, Francesca L. Apolloni, Bangyan Xu, Nghi H. Nguyen, Alexander R. Ziegler, Nichollas E. Scott, Brad E. Sleebs, Laura E. Edgington‐Mitchell   +7 more
wiley   +1 more source

Methionine synthase reductase regulates heterochromatin independently of methionine synthesis through mitochondrial homeostasis

Abstract Metabolic enzymes can influence chromatin organization by modulating the availability of key metabolites, yet how specific metabolic reactions affect chromatin function remains poorly understood. Here, we show that in Caenorhabditis elegans, the methionine-cycle enzyme ...
Fernanda Rezende Pabst, Andrey Tvardovskiy, Iratxe Estibariz, Veronica Finazzi, Pauline Couacault, Anna Artati, Michael Witting, Antonio Scialdone, Till Bartke, Robert Schneider, Daphne Selvaggia Cabianca   +10 more
openaire   +3 more sources

Impeded Electron Transfer From a Pathogenic FMN Domain Mutant of Methionine Synthase Reductase and Its Responsiveness to Flavin Supplementation

, 2016
Methionine synthase reductase (MSR) is a diflavin oxidoreductase that transfers electrons from NADPH to oxidized cobalamin and plays a vital role in repairing inactive cobalamin-dependent methionine synthase.
Uzma Zaman (2406955), Ruma Banerjee (45954), Carmen G. Gherasim (2406961), Ashraf Raza (2406958)   +3 more
core   +1 more source

Relationships among nitrous oxide exposure, neurological injury and biomarkers

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3959-3971, November 2026.
Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Laxna Bhujel, Angela L. Chiew, Bhashita Jagarlamudi, Pramod Chandru, Naren Gunja, Nancy Briggs, Betty S. Chan   +6 more
wiley   +1 more source

Flow diagram of homocysteine metabolism.

, 2015
MAT: methionine adenosyl transferase; SAM: S-adenosyl-methionine; DNMT: DNA methyltransferase; SAH: S-adenosylhomocysteine; MS: methionine synthase; DMG: dimethylglycine; THF: tetrahydrofolate; DHFR: dihydrofolate reductase; DHF: dihydrofolate; 5,10-MTHF:
Donghong Zhang (103883), Xuemei Wen (740694), Wei Wu (27708), Ye Guo (224500), Wei Cui (92129)   +4 more
core   +1 more source