Results 81 to 90 of about 348,762 (206)

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Scheme of the folate-homocysteine pathway (MTX = methotrexate; MTXPG = MTX polyglutamates; DHFR = dihydrofolate reductase; DHF = dihydrofolate; THF = tetrahydrofolate; 5-MTHF = 5-methyl-THF; 5,10-MTHF = 5,10-methylene-THF; HCY = homocysteine; MS = methionine synthase; SAM = S-adenosylmethionine; SAH = S-adenosylhomocysteine).

, 2013
Scheme of the folate-homocysteine pathway (MTX = methotrexate; MTXPG = MTX polyglutamates; DHFR = dihydrofolate reductase; DHF = dihydrofolate; THF = tetrahydrofolate; 5-MTHF = 5-methyl-THF; 5,10-MTHF = 5,10-methylene-THF; HCY = homocysteine; MS ...
Achim Becker (305804), Hauke Rühs (305803), Anne Drescher (305805), Mary V. Relling (47096), John C. Panetta (236025), Ching-Hon Pui (47094), Ulrich Jaehde (93895)   +6 more
core   +1 more source

THE EFFECT OF SINGLE-NUCLEOTIDE POLYMORPHISMS IN THE GENES ENCODING METHYLENETETRAHYDROFOLATE REDUCTASE, METHIONINE SYNTHASE, BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE, AND CYSTATHIONINE BETA-SYNTHASE ON HOMOCYSTEINE LEVELS AND THE RISK OF ISCHEMIC STROKE

Медична наука України
Aim: to analyze the impact of single nucleotide polymorphisms in the genes encoding methylenetetrahydrofolate reductase, methionine synthase, betaine-homocysteine S-methyltransferase, and cystathionine beta-synthase on homocysteine levels and stroke risk
I.G. Strokina, N.V. Motorna
doaj   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Biochemical studies of human methionine synthase reductase

, 2003
Methionine synthase is one of the major enzymes that metabolizes homocysteine and catalyzes the transfer of a methyl group from the substrate, methyltetrahydrofolate to the cobalamin cofactor and subsequently, to the second substrate, homocysteine to ...
Olteanu, Horatiu
core  

HOAs are present in diverse fungal pathogens but absent in their gramineous hosts.

, 2023
The heat map shows the gene number of the key enzymes in the biosynthesis of methionine in fungi and plants examined. CBL, cystathionine β-lyase. CBS, cystathionine β-synthase. CGL, cystathionine γ-lyase. CGS, cystathionine γ-synthase.
Leiyun Yang (2636971), Zhengguang Zhang (190550), Jun Zhang (48506), Xinyu Liu (34266), Zhuoer Xie (7289042), Haifeng Zhang (137541), Ping Wang (42415), Han Chen (228557), Muxing Liu (716957), Huimin Li (126429), Pengcheng Mo (17020969)   +10 more
core   +1 more source

GENETIC POLIMORPHISMS OF ENZYMES INVOLVED IN FOLATE METABOLISM IN HEALTHY SLOVENIAN POPULATION

Zdravniški Vestnik, 2004
Background. Enzymes that play a major role in folate metabolism are 5,10-methylenetetrahydrofolate reductase (MTHFR), thymidilate synthase (TS), methionine synthase (MS) and methionine synthase reductase (MTRR). Polymorphisms in their corresponding genes
Petra Bohanec, Vita Dolžan
doaj  

Structural insights into cobalamin loading and reactivation of human methionine synthase

Nature Communications
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in the methyl transfer from methyltetrahydrofolate to ...
Douglas S. M. Ferreira, Katie McLennan, Calum Diamond, Melanie Vollmar, Wasim Kiyani, D. Sean Froese, Jola Kopec, Henry J. Bailey, Rod Chalk, Arnaud Baslé, Jonathan M. Elkins, Jesse A. Coker, Wyatt W. Yue, Thomas J. McCorvie   +13 more
doaj   +1 more source