Quantitative assessment of the associations between MTR and MTRR gene polymorphisms and glioma risk [PDF]
Discover OncologyPurpose Previous research on the correlation between methionine synthase (MTR) and methionine synthase reductase (MTRR) gene polymorphisms and the susceptibility to glioma has yielded varied results.
Xu Chen, Yanping Yao, Xi Wang, Jun Qiu
doaj +5 more sources
MtrR Regulates a Major Lytic Transglycosylase (ltgA) Responsible for Peptidoglycan-Derived Cytotoxin Release and Autolysis in Neisseria gonorrhoeae [PDF]
MicroorganismsThe multiple-transferable resistance protein (MtrR) is a transcriptional repressor of the mtrCDE-encoded drug efflux pump and Type IV pilus biosynthesis (pilM), and an activator of penicillin-binding protein 1 (ponA) expression in Neisseria gonorrhoeae ...
Alaa I. Telchy +6 more
doaj +3 more sources
MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis
Journal of International Medical Research, 2022 Objective The methionine synthase reductase ( MTRR ) gene encodes the MTRR enzyme involved in the metabolic pathway of homocysteine. Several studies investigated the effect of the MTRR rs1532268 gene polymorphism on the risk of gastric cancer (GC), but ...
Guping Zhong +5 more
doaj +3 more sources
Clinical and Experimental Hypertension, 2023 Objective Hypertension is one of the leading causes of human death and disability. MTHFR and MTRR regulate folate metabolism and are closely linked to hypertension, although the relationship is inconsistent among different ethnic groups.
Shenghe Hu, Genyuan Pu, Caiting Yang
exaly +2 more sources
Genetic influence of PPAR-γ rs1801282 and MTRR rs162036 variants on non-small cell lung cancer risk in Egyptians [PDF]
Discover OncologyBackground Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in diagnostics and treatment, most patients are diagnosed at advanced stages.
Yomna F. Metwally +4 more
doaj +2 more sources
Structural insights into cobalamin loading and reactivation of human methionine synthase [PDF]
Nature CommunicationsHuman methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in the methyl transfer from methyltetrahydrofolate to ...
Douglas S. M. Ferreira +13 more
doaj +2 more sources
Genotype Combinations and Genetic Risk Score Analyses of MTHFR, MTRR, and MTR Polymorphisms in Hypothyroidism Susceptibility: A Case–Control Study [PDF]
Current Issues in Molecular BiologyHypothyroidism is a multifactorial endocrine disorder where genetic predisposition plays a significant role. The MTHFR, MTRR, and MTR genes influence thyroid hormone regulation via homocysteine remethylation and DNA methylation.
Nilgun Tan Tabakoglu +3 more
doaj +2 more sources
Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12 [PDF]
International Journal of Fertility and Sterility, 2021 Background: The relation between key enzymes in regulation of folate metabolism and male infertility is the subjectof numerous studies. We aimed to determine whether 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677Tand methionine synthase reductase
Mozhgan Raigani +4 more
doaj +1 more source
Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients
Неврология, нейропсихиатрия, психосоматика, 2021 In the past decade, stroke incidence in younger adults increased. Methionine synthase reductase (MTRR) A66G polymorphism is one of the risk factors for ischemic stroke (IS).
O. V. Tsyganenko +2 more
doaj +1 more source
mBio, 2022 In a recent mBio article, Ayala et al. (mBio 13:e00276-22, 2022, https://doi.org/10.1128/mbio.00276-22) identified a single nucleotide variant in the repressor gdhR in Neisseria gonorrhoeae that reduces binding to the promoter of the virulence factor ...
Tatum D. Mortimer
doaj +1 more source