Results 11 to 20 of about 4,722 (199)

No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort [PDF]

Journal of the Neurological Sciences, 2007
Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous system (CNS) resulting in debilitating neuropathology. Pathogenesis is primarily defined by CNS inflammation and demyelination of nerve axons. Methionine synthase reductase (MTRR) is an enzyme that catalyzes the remethylation of homocysteine (Hcy) to methionine ...
Szvetko, Attila, Fowdar, Javed, Nelson, J., Colson, Natalie, Tajouri, Lotti, Csurhes, Peter, Pender, Michael, Griffiths, Lyn   +7 more
openaire   +7 more sources

Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice [PDF]

Molecular Genetics and Metabolism Reports, 2020
Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the mechanism through which this occurs is unclear. To improve our understanding of this link, we investigated liver morphology, metabolism and fuel storage in adult mice with a hypomorphic mutation ...
Sowton, Alice P, Padmanabhan, Nisha, Tunster, Simon J, McNally, Ben D, Murgia, Antonio, Yusuf, Aisha, Griffin, Julian L, Murray, Andrew J, Watson, Erica D   +8 more
openaire   +7 more sources

Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR

Nature Communications
Transcriptional regulator MtrR inhibits the expression of the multidrug efflux pump operon mtrCDE in the pathogenic bacterium Neisseria gonorrhoeae. Here, we show that MtrR binds the hormonal steroids progesterone, β-estradiol, and testosterone, which ...
Grace M. Hooks, Julio C. Ayala, Concerta L. Holley, Vijaya Dhulipala, Grace A. Beggs, John R. Perfect, Maria A. Schumacher, William M. Shafer, Richard G. Brennan   +8 more
doaj   +2 more sources

Analysis of spermatogenesis and fertility in adult mice with a hypomorphic mutation in the Mtrr gene [PDF]

Reproduction, Fertility and Development, 2019
Recent research has focussed on the significance of folate metabolism in male fertility. Knocking down the mouse gene Mtrr impedes the progression of folate and methionine metabolism and results in hyperhomocysteinaemia, dysregulation of DNA methylation and developmental phenotypes (e.g. neural tube, heart and placenta defects).
Blake, Georgina, Hall, Jessica, Petkovic, Grace, Watson, Erica   +3 more
openaire   +6 more sources

MTRR 66A>G polymorphism in relation to congenital heart defects

Clinical Chemistry and Laboratory Medicine (CCLM), 2006
AbstractClin Chem Lab Med 2006;44:1317–23.
Beijnum, I.M. van, Kouwenberg, M., Kapusta, L., Heijer, M. den, Linden, I.J. van der, Daniëls, O., Blom, H.J.   +6 more
openaire   +4 more sources

Genetic variant in MTRR, but not MTR, is associated with risk of congenital heart disease: an integrated meta-analysis.

PLoS ONE, 2014
BackgroundCongenital heart disease (CHD) is one of the most common birth defects and the leading cause of deaths among individuals with congenital structural abnormalities worldwide. Both Methionine synthase reductase (MTRR) and Methionine synthase (MTR)
Bingxi Cai, Ti Zhang, Rong Zhong, Li Zou, Beibei Zhu, Wei Chen, Na Shen, Juntao Ke, Jiao Lou, Zhenling Wang, Yu Sun, Lifeng Liu, Ranran Song   +12 more
doaj   +2 more sources

Neutronic peculiarities of the MTRR-SCW reactor as an experimental base for testing advanced light-water reactor technologies [PDF]

Nuclear Energy and Technology
The nuclear power system has faced a challenging issue of significantly improving the characteristics of nuclear fuel breeding while maximizing the advantages of the technology of vessel-type pressurized water reactors used extensively in nuclear power ...
Anton S. Lapin, Viktor Yu. Blandinsky, Vladimir A. Nevinitsa, Stanislav B. Pustovalov, Alexey A. Sedov, Stanislav A. Subbotin, Pyotr A. Fomichenko   +6 more
doaj   +4 more sources

Comparative evaluation of genetic risk models of reproductive disorders caused by MTHFR, MTRR, MTR1 gene polymorphism. [PDF]

Medičnì Perspektivi, 2018
The scientific literature presents contradictory data about influence of folate metabolism genes polymorphism on development of risk of reproductive disorders.
Z. І. Rossokha, S. P. Kyriachenko, N. G. Gorovenko   +2 more
doaj   +2 more sources

H₂-dependent modulation of tetrahydromethanopterin S-methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei. [PDF]

FEBS J
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Habenicht T, Hastedt B, Cassidy L, Kießling C, Tholey A, Schuller JM, Schmitz RA.   +6 more
europepmc   +2 more sources

What’s the Mtrr with Your Grandparents? [PDF]

Cell Metabolism, 2013
Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descendants for up to four generations.
Greer, Eric L., Shi, Yang
openaire   +2 more sources