Results 21 to 30 of about 4,722 (199)

The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae [PDF]

Journal of Bacteriology, 1997
Gonococcal resistance to antimicrobial hydrophobic agents (HAs) is due to energy-dependent removal of HAs from the bacterial cell by the MtrCDE membrane-associated efflux pump. The mtrR (multiple transferrable resistance Regulator) gene encodes a putative transcriptional repressor protein (MtrR) believed to be responsible for regulation of mtrCDE gene ...
C E, Lucas, J T, Balthazar, K E, Hagman, W M, Shafer   +3 more
openaire   +2 more sources

Polymorphisms in maternal selected folate metabolism-related genes in neural tube defect-affected pregnancy

Advanced Biomedical Research, 2023
Background: Neural tube defects (NTDs) are abnormalities of the brain and spinal cord, which occur as a result of failure in neural tube closure during embryogenesis.
Winner K Dewelle, Daniel S Melka, Abenezer T Aklilu, Mahlet Y Gebremariam, Markos A Alemayehu, Dawit H Alemayehu, Tamrayehu S Woldemichael, Solomon G Gebre   +7 more
doaj   +1 more source

Level of homocysteine and polymorphism of genes involved in folate metabolism in women with polycystic ovary syndrome

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. Polycystic ovary syndrome (PCOS) is a multifactorial disease in the development of which gene polymorphism plays an important role.
T.L. Arkhypkina, V.A. Bondarenko, L.P. Lyubimovа, K.V. Misiura   +3 more
doaj   +1 more source

Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans [PDF]

Genomics & Informatics, 2012
Gastric cancer is ranked as the most common cancer in Koreans. A recent molecular biological study about the folate pathway gene revealed the correlation with a couple of cancer types.
Jae-Young Yoo, Sook-Young Kim, Jung-Ah Hwang, Seung-Hyun Hong, Aesun Shin, Il Ju Choi, Yeon-Su Lee   +6 more
doaj   +1 more source

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells. [PDF]

Adv Sci (Weinh)
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Huang J, Fang K, Lu W, Wu R, Chen Y, Li L, Hu Z, Cai Z, Jiang Y, Fan X, Deng J, Liu G, Luo Z, Cui L, Li S.   +14 more
europepmc   +2 more sources

Polymorphism of Folate metabolism genes and risk of lung cancer

Сибирский онкологический журнал, 2019
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality worldwide. Folate metabolism plays an important role in carcinogenesis through its involvement in the process of dNamethylation and repair.The aim of our study ...
M. L. Bakanova, V. I. Minina, Ya. A. Savchenko, A. N. Glushkov   +3 more
doaj   +1 more source

The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis

Archives of Medical Science, 2023
Introduction To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA).
Justyna Roszkiewicz, Dominika Michałek, Aleksandra Ryk, Bartosz Szmyd, Elzbieta Smolewska   +4 more
doaj   +1 more source

The Transcriptional Repressor, MtrR, of the mtrCDE Efflux Pump Operon of Neisseria gonorrhoeae Can Also Serve as an Activator of “off Target” Gene (glnE) Expression

Antibiotics, 2015
MtrR is a well-characterized repressor of the Neisseria gonorrhoeae mtrCDE efflux pump operon. However, results from a previous transcriptional profiling study suggested that MtrR also represses or activates expression of at least sixty genes outside of ...
Paul J. T. Johnson, William M. Shafer
doaj   +1 more source

Association of Three Single Nucleotide Polymorphisms in MTR and MTRR Genes with Lung Cancer in a Turkish Population

, 2021
Aims: Folate metabolism plays a critical role in DNA methylation and synthesis. Polymorphisms in folate metabolism may affect enzyme activities and thereby affect the cancer risk.
Kaytan-Saglam, Esra, Erdenay, Aycin, Aksoy-Sagirli, Pinar, Kizir, Ahmet   +3 more
core   +1 more source

Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma

Analytical Cellular Pathology, 2019
This study was to validate changes in the levels of folate receptor-α (FOLR1), dihydrofolate reductase (DHFR), and methionine synthase reductase (MTRR) in the tissue of OC patients.
Jia Chen, Li Li
doaj   +1 more source