Results 31 to 40 of about 4,722 (199)

Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

Lipids in Health and Disease, 2019
Background The interaction between folate pathway gene polymorphisms and homocysteine, serum lipid leverls are poorly understood in patients with recurrent spontaneous abortion (RSA). The aim of this study is to explore the effects of folate pathway gene
Zhong Lin, Qianxi Li, Yifan Sun, Jingchun Huang, Wan Wang, Jinjian Fu, Jianhua Xu, Dingyuan Zeng   +7 more
doaj   +1 more source

Methyltetrahydrofolate-homocysteine methyltransferase reductase gene and congenital heart defects in Down syndrome

Genetics & Applications, 2020
Congenital heart defects (CHD) are the most common abnormalities occurring in 40% -60% of Down syndrome (DS) patients. The 5-methyltetrahydrofolate homocysteine methyl transferase reductase (MTRR) is one of the key regulatory enzymes involved in folate ...
Jadranka Vraneković, Goran Slivšek, Dijana Majstorović   +2 more
doaj   +1 more source

Associations of homocysteine status and homocysteine metabolism enzyme polymorphisms with hypertension and dyslipidemia in a Chinese hypertensive population

Clinical and Experimental Hypertension, 2020
Background: Hypertension (HTN), dyslipidemia and hyperhomocysteinemia (HHcy) are risk factors for cardiovascular disease (CVD). Methods: Hypertensive Chinese subjects (n = 228) were enrolled. MTHFR C667T, MTHFR A1298C, MTR A2756G, and MTRR A66G genotypes
Xiaojie Yuan, Tingcai Wang, Jie Gao, Yunchao Wang, Yajun Chen, Kanakaraju Kaliannan, Xiaochun Li, Jing Xiao, Tianyou Ma, Lei Zhang, Zhongjun Shao   +10 more
doaj   +1 more source

5‐Fluorouracil‐based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes [PDF]

British Journal of Clinical Pharmacology, 2011
Treatment with 5-fluorouracil (5-FU) is known to improve survival in various cancers. The largest impact of the drug has been reported in colorectal cancer [1]. Active metabolites of 5-FU disrupt both DNA and RNA synthesis through a mechanism involving the folate metabolic pathway [2–4].
Pardini B., Kumar R., Naccarati A., Novotny J., Prasad R. B., Forsti A., Hemminki K., Vodicka P., Lorenzo Bermejo J.   +8 more
openaire   +2 more sources

Association of three missense mutations in the homocysteine-related MTHFR and MTRR gene with risk of polycystic ovary syndrome in Southern Chinese women

Reproductive Biology and Endocrinology, 2021
Background The etiology between homocysteine and polycystic ovary syndrome (PCOS) is unclear. In humans, the level of homocysteine is mainly affected by two enzymes: methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR ...
Wanqin Feng, Yan Zhang, Yuan Pan, Yi Zhang, Minjuan Liu, Yuxin Huang, Yuanling Xiao, Wenyu Mo, Junjie Jiao, Xiaoyang Wang, Dan Tian, Lixia Yang, Ying Ma   +12 more
doaj   +1 more source

Association of methionine synthase reductase (MTRR A66G) polymorphism with susceptibility to acute lymphoblastic leukemia

Italian Journal of Medicine, 2023
Background and Objectives. The enzyme methionine synthase reductase is involved in cellular methylation reactions, DNA synthesis, and epigenetic processes.
Mashaer Taha Edris , Maye Mohammad Merghani , Shaza Salih Gafar , Ahmed Mohamed Asmali, Elrashed B. Yasin, Raed Alserihi , Heba Alkhatabi , Haitham MH. Qutob, Rowaid Qahwaji , Elshazali Widaa Ali   +9 more
doaj   +1 more source

Reassessment of <i>MTRR</i> rs1801394 Polymorphism and Neural Tube Defects Risk. [PDF]

Matern Fetal Med
Muruganantham JK, Veerabathiran R.
europepmc   +4 more sources

MTHFR and MTRR Genetic Polymorphism of Methotrexate Therapy Outcomes in Early Rheumatoid Arthritis

Pharmacogenomics and Personalized Medicine, 2023
Methotrexate (MTX) is used as an anchor drug for the treatment of rheumatoid arthritis (RA) and there may be differences in drug action between genotypes. The purpose of this study was to investigate the relationship between clinical efficacy response and disease activity of MTX monotherapy with methylenetetrahydrofolate reductase (MTHFR) and ...
Qian Zhang, Pan Fu, Zhanglei Cao, Hua Huang, Qinwen Wen, Kaizhe Wang, Tong Kong, Xiudi Wu, Jianping Zheng   +8 more
openaire   +4 more sources

Disruption of Folate Metabolism Causes Poor Alignment and Spacing of Mouse Conceptuses for Multiple Generations

Frontiers in Cell and Developmental Biology, 2021
Abnormal uptake or metabolism of folate increases risk of human pregnancy complications, though the mechanism is unclear. Here, we explore how defective folate metabolism influences early development by analysing mice with the hypomorphic Mtrrgt mutation.
Amy L. Wilkinson, Katerina Menelaou, Joanna Rakoczy, Xiu S. Tan, Erica D. Watson   +4 more
doaj   +1 more source

Telomere Dynamics in Congenital Heart Defects: Hidden Architects of Cardiogenesis? [PDF]

Hum Mutat
Background Congenital heart defects (CHDs) represent a significant global health burden, particularly in India, and are among the leading causes of childhood mortality. Despite growing insights into their multifactorial etiology, the molecular mechanisms linking maternal health to embryonic heart development remain elusive.
Joshi R, Nath S, Gupta S.
europepmc   +2 more sources