Results 171 to 180 of about 348,762 (206)
Cobalamin Uptake and Reactivation Occurs Through Specific Protein Interactions in the Methionine Synthase–Methionine Synthase Reductase Complex [PDF]
FEBS Journal, 2009 Human methionine synthase reductase (MSR), a diflavin enzyme, restores the activity of human methionine synthase through reductive methylation of methionine synthase (MS)‐bound cob(II)alamin. Recently, it was also reported that MSR enhances uptake of cobalamin by apo‐MS, a role associated with the MSR‐catalysed reduction of ...
Kirsten R Wolthers, Nigel Scrutton
exaly +4 more sources
Methionine Synthase and Methionine Synthase Reductase Interact With MMACHC and With MMADHC
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2017 An increasing number of studies indicate that each step of the intracellular processing of vitamin B12 or cobalamin (Cbl) involves protein-protein interactions. We have previously described a novel interaction between methionine synthase (MS) and MMACHC and its effect on the regulation of MMACHC activity.
David Coelho +2 more
exaly +6 more sources
American Journal of Medical Genetics, Part A, 2004 AbstractHyperhomocysteinemia is a risk factor for thrombosis, and methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms, folate, and B12 levels could contribute to plasma homocysteine (Hcy) variation. Although well established in adults, few studies have been performed in childhood.
Sergio Paulo Bydlowski +2 more
exaly +5 more sources
Metabolic Derangement of Methionine and Folate Metabolism in Mice Deficient in Methionine Synthase Reductase [PDF]
Molecular Genetics and Metabolism, 2007 Hyperhomocyst(e)inemia is a metabolic derangement that is linked to the distribution of folate pools, which provide one-carbon units for biosynthesis of purines and thymidylate and for remethylation of homocysteine to form methionine. In humans, methionine synthase deficiency results in the accumulation of methyltetrahydrofolate at the expense of ...
Teodoro Bottiglieri +2 more
exaly +3 more sources
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Genes & Genomics, 2020
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are strongly associated with hypertension incidence, although such association is inconsistent among ethnicities studied. However, effects of polymorphisms of other genes related to folate metabolism besides MTHFR on hypertension susceptibility are not well known yet.The aim of this ...
Young Ree Kim +2 more
openaire +4 more sources
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are strongly associated with hypertension incidence, although such association is inconsistent among ethnicities studied. However, effects of polymorphisms of other genes related to folate metabolism besides MTHFR on hypertension susceptibility are not well known yet.The aim of this ...
Young Ree Kim +2 more
openaire +4 more sources
Journal of Maternal-Fetal and Neonatal Medicine, 2017
The aim of the study was to determine the MTR (methionine synthase) and MTRR (mehionine synthase reductase) polymorphisms in pregnant women with preeclampsia (PE).The group of 98 women with PE and the group of 120 healthy pregnant women were analyzed.
Anna Bogacz +2 more
exaly +3 more sources
The aim of the study was to determine the MTR (methionine synthase) and MTRR (mehionine synthase reductase) polymorphisms in pregnant women with preeclampsia (PE).The group of 98 women with PE and the group of 120 healthy pregnant women were analyzed.
Anna Bogacz +2 more
exaly +3 more sources
Restricted Role for Methionine Synthase Reductase Defined by Subcellular Localization [PDF]
Molecular Genetics and Metabolism, 2008 Methionine synthase reductase (MSR; gene name MTRR) is responsible for the reductive activation of methionine synthase. Cloning of the MTRR gene had revealed two major transcription start sites which, by alternative splicing, allows for two potential translation products of 698 and 725 amino acids.
M Amrein, R A Gravel
exaly +3 more sources
Atherosclerosis, 2003
The metabolism of homocysteine requires contributions of several enzymes and vitamin cofactors. Earlier studies identified a common polymorphism of methylenetetrahydrofolate reductase that was associated with mild hyperhomocysteinemia. Common variants of two other enzymes involved in homocysteine metabolism, methionine synthase and methionine synthase ...
Paul F Jacques +2 more
exaly +3 more sources
The metabolism of homocysteine requires contributions of several enzymes and vitamin cofactors. Earlier studies identified a common polymorphism of methylenetetrahydrofolate reductase that was associated with mild hyperhomocysteinemia. Common variants of two other enzymes involved in homocysteine metabolism, methionine synthase and methionine synthase ...
Paul F Jacques +2 more
exaly +3 more sources
Biochemistry, 2007
Methionine synthase (MS) is a cobalamin-dependent enzyme. It transfers a methyl group from methyltetrahydrofolate to homocysteine forming methionine and tetrahydrofolate. On the basis of sequence similarity with Escherichia coli cobalamin-dependent MS (MetH), human MS comprises four discrete functional modules that bind from the N- to C-terminus ...
Wolthers, Kirsten R., Scrutton, Nigel S.
openaire +3 more sources
Methionine synthase (MS) is a cobalamin-dependent enzyme. It transfers a methyl group from methyltetrahydrofolate to homocysteine forming methionine and tetrahydrofolate. On the basis of sequence similarity with Escherichia coli cobalamin-dependent MS (MetH), human MS comprises four discrete functional modules that bind from the N- to C-terminus ...
Wolthers, Kirsten R., Scrutton, Nigel S.
openaire +3 more sources
Journal of Neuro-Oncology, 2013
The causes of meningiomas are not well understood. Folate metabolism gene polymorphisms have been shown to be associated with various human cancers. It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase
Jun, Zhang +6 more
openaire +2 more sources
The causes of meningiomas are not well understood. Folate metabolism gene polymorphisms have been shown to be associated with various human cancers. It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase
Jun, Zhang +6 more
openaire +2 more sources