Results 181 to 190 of about 348,762 (206)

Relationship Between Methionine Synthase, Methionine Synthase Reductase Genetic Polymorphisms and Deep Vein Thrombosis Among South Indians

Clinical Chemistry and Laboratory Medicine, 2008
The rationale behind this study was to examine the relationship between polymorphisms in genes that regulate remethylation of homocysteine to methionine, i.e., methionine synthase (MTR A2756G) and methionine synthase reductase (MTRR A66G), and risk of deep vein thrombosis (DVT) in a South Indian cohort (163 DVT cases and 163 controls), as elevated ...
Shaik Mohammad Naushad
exaly   +3 more sources

cblE Type of Homocystinuria Due to Methionine Synthase Reductase Deficiency: Functional Correction by Minigene Expression

Human Mutation, 2005
The cblE type of homocystinuria is a rare autosomal recessive disorder caused by impaired reductive activation of methionine synthase. Although earlier biochemical studies proposed that the methionine synthase enzyme might be activated by two different ...
Viktor Kožich, Laura Vilarinho, Jiří Zeman   +2 more
exaly   +3 more sources

The Methionine Synthase Reductase (MTRR) A66G Polymorphism Is a Novel Genetic Determinant of Plasma Homocysteine Concentrations

Atherosclerosis, 2001
Epidemiological evidence has revealed that an elevated plasma homocysteine level (hyperhomocysteinemia) confers an increased risk of cardiovascular disease and neural tube defects. Hyperhomocysteinemia is caused by both nutritional (e.g. folate, vitamins
Leo A J Kluijtmans, Sandrine Barbaux, Ian Young   +2 more
exaly   +2 more sources

Biochemical Studies of Human Methionine Synthase Reductase

2002
Elevated levels of plasma homocysteine are regarded as an independent risk factor for cardiovascular diseases (CVD) (1) and neural tube defects (NTD) (2). A recent meta-analysis estimated that 10% of the risk for coronary artery disease in the general population can be attributed to elevated homocysteine and that, for every 5 µmol/l increase in plasma ...
H. Olteanu, R. Banerjee
openaire   +1 more source

Effects of Methionine Synthase (MS) A2756G and Methionine Synthase Reductase (MSR) A66G Polymorphisms on Methionine Metabolism in Brazilian Pregnant Women and Their Neonates.

Blood, 2004
Abstract Methionine synthase (MS) is a cobalamin dependent enzyme that catalyses the remethylation of homocysteine to methionine. The methionine synthase reductase (MSR) maintains adequate levels of methylcob(III)alamin, the activated cofactor for MS.
Patricia R. Barbosa, Sally P. Stabler, Mario H. Hirata, Rosario D.C. Hirata, Robert H. Allen, Luiz F. Sampaio-Neto, Elvira M. Guerra-Shinohara   +6 more
openaire   +1 more source

Differences in the Efficiency of Reductive Activation of Methionine Synthase and Exogenous Electron Acceptors between the Common Polymorphic Variants of Human Methionine Synthase Reductase

Biochemistry, 2002
Methionine synthase reductase (MSR) catalyzes the conversion of the inactive form of human methionine synthase to the active state of the enzyme. This reaction is of paramount physiological importance since methionine synthase is an essential enzyme that plays a key role in the methionine and folate cycles.
Horatiu, Olteanu, Troy, Munson, Ruma, Banerjee   +2 more
openaire   +2 more sources

Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease

Acta Cardiologica, 2006
Elevated plasma total homocysteine (tHcy) is increasingly being recognized as a risk factor for coronary artery disease (CAD) and other defects. Recent genetic studies have characterized molecular determinants contributing to altered homocysteine metabolism.
LARAQUI, Abdelilah, ALLAMI, Abdellatif, CARRIÉ, Alain, COIFFARD, Sophie, BENKOUKA, Fatima, BENJOUAD, Abdelaziz, BENDRISS, Abdenabi, KADIRI, Nizar, BENNOUAR, Nawal, BENOMAR, Anwar, GUEDIRA, Abdelghafour, RAISONNIER, Alain, FELLAT, Seddik, SRAIRI, Jamal-Eddine, BENOMAR, Mohamed   +14 more
openaire   +2 more sources

Polymorphisms ofMethionine SynthaseandMethionine Synthase Reductaseand Risk of Squamous Cell Carcinoma of the Head and Neck: a Case-Control Analysis

Cancer Epidemiology, Biomarkers & Prevention, 2005
AbstractAlthough tobacco and alcohol use are the major risk factors, folate deficiency has been implicated in the risk of squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) in the folate matabolic pathway are associated with SCCHN risk.
Zhengdong, Zhang, Qiuling, Shi, Zhensheng, Liu, Erich M, Sturgis, Margaret R, Spitz, Qingyi, Wei   +5 more
openaire   +2 more sources

Functional variant in methionine synthase reductase decreases the risk of Down syndrome in China

Journal of Obstetrics and Gynaecology Research, 2012
AbstractAim:  Down syndrome (DS) is the most common genetic cause of human mental retardation and the genes involved in homocysteine/folate metabolism may play important roles in this condition. Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine.
Shao-Shuai, Wang, Ling, Feng, Fu-Yuan, Qiao, Juan-Juan, Lv   +3 more
openaire   +2 more sources

Methylenetetrahydrofolate reductase and methionine synthase polymorphisms and risk of bladder cancer in a Tunisian population

Cancer Genetics and Cytogenetics, 2007
Folate insufficiency can induce carcinogenesis by decreasing DNA methylation. It is well known that DNA hypomethylation is a common feature in a number of cancers. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are enzymes that play central roles in the folate metabolic pathway.
Slah, Ouerhani, Elisabete, Oliveira, Raja, Marrakchi, Mohamed R, Ben Slama, Mohamed, Sfaxi, Mohsen, Ayed, Mohamed, Chebil, António, Amorim, Amel Benammar, El Gaaied, Maria João, Prata   +9 more
openaire   +2 more sources